Investigating the Cell Division Machinery

研究细胞分裂机制

• 批准号: 10796673
• 负责人: Jorge Torres
• 金额: $ 1.47万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796673
• 关键词: Administrative Supplement; Area; Cell Cycle; Cell division; Cells; Cellular biology; Communication; Complex; Coupled; Critical Thinking; Cytoskeleton; Data Analyses; Development; Development Plans; Disease; Environment; Enzymes; Ethics; Event; Experimental Designs; Exposure to; Human; Malignant Neoplasms; Mentors; Microtubules; Mitotic spindle; Modernization; Molecular Biology; Oral; Post-Translational Protein Processing; Postdoctoral Fellow; Proteins; Research; Research Institute; Research Training; Sister Chromatid; Structure; Students; Talents; Training; Writing; career; career development; collaborative environment; experience; interdisciplinary approach; meetings; novel; programs; protein complex; protein protein interaction; research study; segregation; skills; summer research; supportive environment; symposium; undergraduate research; undergraduate student

SUMMARY Cell division is a complex and specifically orchestrated set of events that culminates in the equal segregation of sister chromatids into two cells. It relies on a multitude of protein complexes, protein- protein interactions, and regulatory mechanisms driven by the activities of posttranslational modification enzymes. The Torres lab uses multidisciplinary approaches to investigate the enzymes and regulatory mechanisms that are necessary to carry out human cell division with high fidelity, which are often dysregulated in diseases like cancer. This dynamic research environment provides students a unique opportunity to obtain broad foundational training in modern cell and molecular biology. This administrative supplement will allow one talented undergraduate student to immerse in a comprehensive research and career training experience for ten weeks during the summer of 2023. The Torres lab will provide a dynamic, inclusive, collaborative, and supportive environment, where the student will acquire technical, operational, and professional skills that will prepare them for a biomedical career. The student will carry out research on a novel set of related proteins that localize to microtubule-based structures and that are important for their function, including mitotic spindle assembly, which lies within the scope of the original MIRA project. The student will gain rigorous experimental design skills; statistical and quantitative skills for data analysis; analytical and critical thinking skills; oral and written communication skills; and an understanding of how to conduct safe and ethical research studies. The student’s research experience will be coupled with exposure to broad areas of cell and molecular biology related to the cell cycle and cytoskeleton and the development of professional skills. This will include student attendance and research presentations at Torres lab meetings, the UCLA cytoskeleton supergroup meetings, the UCLA undergraduate research symposium, and molecular biology institute research seminars. Additionally, the student will receive one-on-one mentoring and hands on training from the PI and a staff research associate on a regular basis. Together, this comprehensive student-centered mentoring, research training, and career development plan will enable the student to successfully prepare for a biomedical career.

概括 细胞分裂是一组复杂且特殊精心策划的事件，最终达到相等 姊妹染色质素分离成两个细胞。它依靠多种蛋白质复合物，蛋白质 - 蛋白质相互作用以及受翻译后活性驱动的调节机制 修饰酶。托雷斯实验室使用多学科的方法来研究酶 以及以高忠诚进行人类细胞分裂所必需的调节机制， 在癌症等疾病中通常会失调。这个动态的研究环境提供了 学生是获得现代细胞和分子的广泛基础培训的独特机会 生物学。这种行政补充剂将允许一名才华横溢的本科生沉浸在 在2023年夏季，全面的研究和职业培训经验已有十个星期。 托雷斯实验室将提供一个动态，包容，协作和支持的环境，其中 学生将获得技术，运营和专业技能，这将为他们做好准备 生物医学职业。该学生将对一套本地化的新型相关蛋白质进行研究 到基于微管的结构，对其功能很重要，包括有丝分裂纺锤体 大会，位于原始Mira项目的范围内。学生将获得严格的 实验设计技能；数据分析的统计和定量技能；分析和关键 思维技能；口头和书面沟通技巧；并了解如何安全 和道德研究。学生的研究经验将与接触 细胞和分子生物学的广泛区域与细胞周期和细胞骨架以及 发展专业技能。这将包括学生出勤和研究演讲 托雷斯实验室会议，UCLA CYTOSKETERNON超组会议，UCLA本科生 研究研讨会和分子生物学研究所的研究中心。此外，学生还将 接受一对一的心理，并接受PI的培训，并在A 定期。这项全面以学生为中心的心理，研究培训和 职业发展计划将使学生能够成功为生物医学职业做准备。