UofL RBL Operations, Workforce Development and Pandemic Preparedness Research

SUMMARY (OVERALL): The University of Louisville Regional Biocontainment Laboratory (RBL) is operated by the University Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The RBL is a regional resource that facilitates translational research to develop diagnostics, prognostics, therapeutics and vaccines to mitigate biodefense and emerging infectious disease threats. Our Center operates the only BSL-3 and ABSL-3 facilities currently operating in the Commonwealth of Kentucky. The CPM mandate is to prepare for and respond to public health emergencies, such as the COVID-19 pandemic. The broad, long-range objectives and goals of the University of Louisville (UofL) CPM RBL are: 1. To offer state-of-the-art research services to the regional and national biomedical research community to learn from past pandemics and biological warfare experiences and effectively predict and mitigate future emerging infectious disease threats. 2. To manage, maintain and operate the UofL RBL to serve the national and regional need for biocontainment facilities suitable for research on Risk Group 3 pathogens and other biothreats. 3. To follow a philosophy of continuous improvement in BSL-3 and ABSL-3 work practices and to ensure that all personnel who need to access BSL-3 and ABSL-3 containment laboratories are appropriately trained and prepared to serve the national and regional need for biocontainment research professionals. To achieve these aims we propose to establish three collaborative Cores. The Facilities Management Maintenance and Operations Core (FMMO Core) is responsible for ensuring that the facility is always available to meet the research and emergency preparedness mission of the RBL. The BSL-3 Practices and Workforce Development Core (BSL-3PWD Core) formalizes our mentor-mentee training plan to ensure our laboratory is staffed with BSL-3 research professionals who are proficient at biocontainment research professionals. This core responds to the reality that response to rapidly emerging public health emergencies like COVID-19 is limited by the number of available BSL-3 trained and experienced research professionals. Our Pandemic Preparedness and Response Integrated Research Core (PaPR Core) responds to the substantially increased requests for our BSL-3 research services by organizing an integrated full-service BSL-3 research support function to support investigator needs. These cores will work in unison to achieve the CPM mission: to prepare for and respond to public health emergencies like the COVID-19 pandemic.

摘要（总体）： 路易斯维尔大学区域生物卫生实验室（RBL）由大学中心运营 生物障碍和新兴传染病（CPM）的预测医学。 RBL是区域资源 这有助于转化研究以开发诊断，预后，治疗和疫苗以减轻 生物形式和新兴的传染病威胁。我们的中心运营唯一的BSL-3和ABSL-3设施 目前在肯塔基州的联邦运作。 CPM授权是为公众做准备和回应 健康紧急情况，例如COVID-19大流行。 路易斯维尔大学（UOFL）CPM RBL的广泛，远程目标和目标是： 1。向区域和国家生物医学研究界提供最先进的研究服务 从过去的大流行和生物战经验中学习，并有效预测并减轻未来 新兴的传染病威胁。 2。管理，维护和操作UOFL RBL以满足国家和地区生物培养的需求 适用于风险研究3病原体和其他生物治疗的设施。 3。遵循BSL-3和ABSL-3工作实践的持续改进的理念，并确保 所有需要访问BSL-3和ABSL-3的人员都经过适当培训，并且 准备满足国家和区域生物维护研究专业人员的需求。 为了实现这些目标，我们建议建立三个协作核心。设施管理 维护和操作核心（FMMO核心）负责确保该设施始终可用 满足RBL的研究和应急准备任务。 BSL-3实践和劳动力 开发核心（BSL-3PWD核心）正式化了我们的导师训练计划，以确保我们的实验室是 精通生物培养研究专业人员的BSL-3研究专业人员。这个核心 回应以下事实：诸如Covid-19之类的快速新兴公共卫生紧急情况的反应受到限制 可用的BSL-3培训和经验丰富的研究专业人员的数量。我们的大流行准备 响应综合研究核心（PAPR核心）对我们的要求大大增加了请求 BSL-3研究服务通过组织综合的全方位服务BSL-3研究支持功能来支持 调查员需要。这些核心将一致努力实现CPM任务：准备和回应 公共卫生的紧急情况，例如COVID-19大流行。