BSL-3 Practices Core

BSL-3 实践核心

• 批准号: 10793909
• 负责人: Rebecca Moritz
• 金额: $ 63.43万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793909
• 关键词: Animal Husbandry; Area; Awareness; Biometry; Bioterrorism; Charge; Colorado; Communities; Competence; Comprehension; Containment; County; Dedications; Educational Curriculum; Educational process of instructing; Educational workshop; Effectiveness; Elements; Emergency Situation; Emergency response; Ensure; Environment; Equipment and supply inventories; Evaluation; Evolution; Exercise; Feedback; Fostering; Funding; Goals; Human Resources; Information Technology; Infrastructure; Institution; Investigation; Laboratories; Laboratory Personnel; Laboratory Research; Maintenance; Mission; Modernization; Persons; Policies; Procedures; Process; Public Health; Reaction; Reader; Readiness; Research; Research Personnel; Resource Development; Resources; Safety; Secure; Security; Specialist; Standardization; System; Time; Training; Universities; Update; Work; Workforce Development; biosecurity; design; emergency preparedness; evidence base; experience; flexibility; improved; intrusion detection system; member; operation; prevent; programs; risk mitigation; synergism

Project Summary: The Rocky Mountain Regional Biocontainment Laboratory (RMRBL) must maintain excellence in biosafety and biosecurity to fulfill its charge of responding to public health and potential bioterrorism emergencies. Updating, modernizing, and continuously improving the biosafety and biosecurity program at the RMRBL ensures that researchers can effectively contribute to the important mission of the RBL network. This BSL-3 Practices Core will facilitate the long-term goals for sustaining high quality biosafety and biosecurity in the RMRBL through three overarching aims. Aim 1- Continuous evolution of biosafety and biosecurity for a dynamic research environment is critical for protecting researchers, the community, and the environment. Efforts supported by this funding will include modernizing current training using universal design principles and evidence-based teaching strategies for improved retention. New feedback mechanisms will be developed to promote regular updates to training based on ever-changing research needs. Emergency response and crisis management training will be amplified so personnel are better equipped to automatically react according to standard operating procedures. This includes coordinating with external emergency management partners for live scenarios and table-top exercises. Aim 2- Enhancing biosecurity through modernization of physical and administrative infrastructure will bring current RMRBL biosecurity systems up to date and provide a robust framework for a comprehensive biosecurity program. Keeping up with rapid changes in information technology and global interconnectedness is an increasing challenge. Through this project, the RMRBL biosecurity program will undergo physical security upgrades and administrative support expansion. Considering the increased public awareness of high containment laboratory research, proactive changes to the RMRBL biosecurity program will facilitate adaptation in the face of a changing regulatory environment. This is essential for constant readiness in line with the mission of the RBL network. Aim 3- Strengthening administrative controls for alignment with biosafety and biosecurity best practices will build safety culture among RMRBL personnel. In synergy with Aim 1, standard operating procedures (SOPs), plans, policies, practices, and inventory systems will be strategically reviewed and updated with an emphasis on researcher comprehension and ease of use. Developing consistent feedback mechanisms for users about the effectiveness of administrative controls will increase buy-in. New ideas for improving RMRBL processes will be gathered during personnel exchanges with other RBL network biosafety teams. Additionally, biosafety and biosecurity best practices will be reinforced through systematic investigation of the effectiveness of risk mitigation strategies. In sum, this core will ensure that biosafety and biosecurity at the RMRBL is contemporary and flexible to adequately support the mission of the RBL network.

项目摘要：落基山地区生物防护实验室 (RMRBL) 必须维护 卓越的生物安全和生物安保，以履行其响应公共卫生和潜力的职责 生物恐怖主义紧急情况。更新、现代化并不断改进生物安全和 RMRBL 的生物安全计划确保研究人员能够有效地为重要的研究做出贡献 RBL 网络的使命。此 BSL-3 实践核心将有助于实现维持可持续发展的长期目标 RMRBL 通过三个总体目标实现高质量的生物安全和生物安保。目标 1 - 持续 动态研究环境的生物安全和生物安保的演变对于保护生物安全至关重要 研究人员、社区和环境。这笔资金支持的努力将包括 利用通用设计原则和循证教学策略实现当前培训的现代化 以提高保留率。将制定新的反馈机制，以促进定期更新 基于不断变化的研究需求的培训。应急响应和危机管理培训 将被放大，以便人员能够更好地根据标准操作自动做出反应 程序。这包括与外部应急管理合作伙伴协调现场场景 和桌面练习。目标 2 - 通过物理和技术现代化加强生物安全 行政基础设施将使当前的 RMRBL 生物安全系统更新并提供强大的 综合生物安全计划框架。跟上信息的快速变化 技术和全球互联互通是一个日益严峻的挑战。通过这个项目，RMRBL 生物安全计划将进行物理安全升级和行政支持扩展。 考虑到公众对高遏制实验室研究的认识不断增强，积极主动的变革 RMRBL 生物安全计划将有助于适应不断变化的监管 环境。这对于根据 RBL 网络的使命保持持续准备状态至关重要。目标 3- 加强行政控制，以符合生物安全和生物安保最佳实践 RMRBL 人员的安全文化。与目标 1、标准操作程序 (SOP) 协同作用， 将对计划、政策、做法和库存系统进行战略性审查和更新 强调研究人员的理解和易用性。制定一致的反馈机制 对于用户来说，关于管理控制有效性的认可度将会提高。改进的新思路 RMRBL 流程将在与其他 RBL 网络生物安全团队的人员交流期间收集。 此外，将通过系统调查加强生物安全和生物安保最佳实践 风险缓解策略的有效性。总之，这一核心将确保生物安全和生物安保 RMRBL 的网络现代化且灵活，足以支持 RBL 网络的使命。