Chemistry Services for the National Toxicology Program (General Chemistry Support and Contract Administration)

国家毒理学计划的化学服务（一般化学支持和合同管理）

• 批准号: 10788035
• 负责人: RESHAN FERNANDO
• 金额: $ 357.33万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-30 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788035
• 关键词: Acrylamides; Adverse effects; Behavior; Biological; Blood; Cardiovascular system; Chemical Exposure; Chemicals; Chemistry; Contracts; Coumarins; Data; Development; Dose; Environmental Exposure; Evaluation; Exposure to; Formulation; Furans; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Hepatic; Hepatocyte; Hexachlorobenzene; Human; In Vitro; Individual; Lamivudine; Metabolism; Microsomes; Monoterpenes; National Toxicology Program; Oral; Outcome; Oxides; Pilot Projects; Preparation; Process; Raloxifene; Rattus; Reporting; Research; Risk; Risk Assessment; Risk Factors; Rodent; Sampling; Services; Sodium; Specific qualifier value; Sulfate; Testing; Thallium; Toxic effect; Toxicity Tests; Toxicokinetics; Toxicology; Triclosan; Urine; Work; abacavir; cardiovascular health; data modeling; disorder prevention; dose information; inorganic phosphate; programs; public health research; sodium arsenite; sound; transcriptomics

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该项目的目的是提供支持国家毒理学计划（DNTP）危害识别活动，该危害识别活动针对预防疾病或由环境暴露于化学或物理药物引起的不良影响。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学物质。该合同有助于毒性研究能够通过提供所研究的化学物质的表征，确认给予的剂量水平和内部剂量确定来提供癌症风险增加以及其他毒理学结果的证据。该信息对于评估毒性测试和声音的发展至关重要，有关研究化学物质中潜在毒性的科学结论，最终支持国家毒理学计划和其他联邦机构的风险评估工作。有了本合同提供的内部剂量信息，可以对人类进行外推，以便可以充分了解公众对研究化学物质的风险因素。