Quantitative Ultrasound for Assessment of Placental Structure During the Development of Preeclampsia

定量超声评估先兆子痫发展过程中的胎盘结构

• 批准号: 10790437
• 负责人: Carolyn Louise Bayer
• 金额: $ 44.26万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10790437
• 关键词: Acute; Blood Vessels; Blood flow; Clinic; Clinical; Clinical assessments; Decidua; Dedications; Development; Diagnosis; Discipline of obstetrics; Disease Progression; Doppler Ultrasound; Early Diagnosis; Early Intervention; Elasticity; Endometrium; Etiology; Fetal health; Fibrosis; First Pregnancy Trimester; Funding; Funding Opportunities; Future; Goals; Growth; Health; Histopathology; Human; Image; Imaging Device; Injury; Invaded; Knowledge; Magnetic Resonance Imaging; Maternal Health; Medical Imaging; Medicine; Methods; Mission; Modeling; New York; Outcome; Patient-Focused Outcomes; Perfusion; Placenta; Placental Insufficiency; Placentation; Pre-Eclampsia; Pregnancy; Prevention; Process; Property; Proteinuria; Public Health; Rattus; Research; Resolution; Resources; Risk; Rodent Model; Screening procedure; Severities; Signal Transduction; Structure; System; Testing; Time; Tissues; Ultrasonography; United States National Institutes of Health; Universities; Uterus; Validation; Woman; Work; attenuation; clinical translation; cost; effective therapy; elastography; endothelial dysfunction; fetal; imaging modality; improved; improved outcome; in vivo; in vivo imaging; maternal hypertension; novel; novel strategies; point of care; pressure; quantitative ultrasound; radio frequency; response; soft tissue; statistics; success; tissue injury; tool; ultrasound

PROJECT SUMMARY A lack of effective treatments for preeclampsia persists due, in part, to our inability to detect altered placental tissue microstructure as an indicator of abnormal placental development. This application proposes a MPI collaborative study to be performed by Weill Cornell Medicine (WCM) in New York, NY and Tulane University (TU) in New Orleans, LA. The proposed project is responsive to the Human Placenta Project PAR-22-236 and seeks to develop a novel ultrasound approach for “safe, real-time, and non-invasive” assessment of “the development … of the human placenta across pregnancy”. Our long-term goal is to develop imaging tools to improve outcomes in women with preeclampsia. The overall objective of this proposal is to develop and validate quantitative ultrasound (QUS) to detect and correlate microstructural alterations in the placenta with preeclampsia. QUS uses radio-frequency (RF) US signals to characterize soft tissues quantitatively. We hypothesize that QUS-based parameters will be capable of quantifying the microstructural changes which characterize preeclampsia. Guided by a strong scientific premise, this hypothesis will be tested by pursing two specific aims: 1) To quantify altered human placental microstructure ex vivo; and 2) To assess placental microstructure longitudinally in vivo in an established rodent model of preeclampsia. Under the first aim, we will develop QUS methods to characterize the human placenta and test the hypothesis that specific QUS parameters will correlate with altered vascular development and injury in the ex vivo human preeclamptic placenta, with histopathology as the gold standard. The second aim will test the hypothesis that QUS parameters will correlate with microstructural and changes due to altered vasculature and fibrosis in the reduced uterine perfusion pressure rat model of preeclampsia. The expected outcome of this work will be the validation of QUS-derived parameters for the assessment of placental microstructure. With these imaging methods, we anticipate correlating specific QUS parameters related to placental microstructure with the diagnosis of preeclampsia. This outcome will strongly motivate the dedication of additional resources for clinical translation and in vivo longitudinal validation of QUS to earlier detect and predict severity of preeclampsia in women. Consistent with the goals of this funding opportunity and the goals of the HPP, this work will lead to the development of a new point-of-care ultrasound assessment of preeclampsia risk and severity, which can be accomplished using the ultrasound systems existing in the clinic.

项目摘要 缺乏有效的先兆子痫的治疗方法，部分原因是我们无法检测到改变的斑点 组织微观结构作为异常斑点发育的指标。此申请提出MPI 合作研究将由纽约，纽约和杜兰大学的Weill Cornell Medicine（WCM）进行 （tu）在新奥尔良，洛杉矶。拟议的项目对人类Pleceta项目PAR-22-236有回应 并寻求开发一种新颖的超声方法，以“安​​全，实时和无创”评估“ 整个怀孕期间的人物的发展……我们的长期目标是开发成像工具 先兆子痫女性的预后改善。该提案的总体目的是发展和 验证定量超声（QUS），以检测和相关的位置中的微结构改变与 子痫前期。 QUS使用射频（RF）美国信号来定量表征软组织。我们 假设基于QUS的参数将能够量化微观结构的变化 表征先兆子痫。在强大的科学前提下，将通过追求来检验该假设 两个具体的目的：1）量化人类位置微观结构的变化； 2）评估占地 微观结构在既定的啮齿动物前启示性模型中的体内纵向。在第一个目标下，我们 将开发QUS方法来表征人的plapeta并检验特定QUS的假设 参数将与体内人类前疗法的血管发育和损伤发生变化有关 胎盘，组织病理学作为黄金标准。第二个目标将检验QUS的假设 参数将与微观结构和随着脉管系统的改变和纤维化的变化相关。 子宫灌注压力大鼠的先兆子痫模型降低。这项工作的预期结果将是 QUS衍生的参数评估位置微结构的验证。使用这些成像 方法，我们预计将与位置微结构相关的特定QU参数与 诊断先兆子痫的诊断。这种结果将强烈激发其他资源的奉献精神 QUS的临床翻译和体内纵向验证以早期检测和预测 女性的子痫前期。与这个资金机会的目标和HPP目标的目标一致 工作将导致对先兆子痫风险和 严重性，可以使用诊所中现有的超声系统来完成。