CORE-001 - OPERATIONS CORE

CORE-001 - 运营核心

• 批准号: 10728896
• 负责人: Lauren Ferrante
• 金额: $ 30.02万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728896
• 关键词: Aging; American; Award; Biometry; Biostatistics Core; Budgets; Capsicum; Caring; Clinical Informatics; Collaborations; Communities; Computer software; Consultations; Data; Data Collection; Data Mart; Data Reporting; Development; Education; Elderly; Ensure; Equipment; Extramural Activities; Fostering; Funding; Funding Agency; Future; Goals; Grant; Health system; Informatics; Infrastructure; Institution; Investigation; Mentors; Methodology; Mission; Monitor; Peer Review; Policies; Population; Publications; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Services; Silver; Software Design; Software Tools; System; Training; United States National Institutes of Health; Veterans Health Administration; Work; data management; data sharing; database design; design; electronic data; electronic data capture system; improved; informatics infrastructure; innovation; next generation; novel; operation; participant safety; programs; recruit; skills; software development; technological innovation; tool

The Operations Core (OC) supports research on multifactorial geriatric conditions by recruiting older adults who are diverse and representative, engaging older adults from the community as stakeholders, monitoring the safety of participants, offering resources to support aging research, designing electronic data collection sys- tems that result in high-quality data, developing software applications to support study workflow and analysis, and collecting, preparing and reporting data that account for the complexity of multifactorial aging research. The overall goal of the OC (RC1) is to ensure the successful implementation of multifactorial aging research. This goal will be accomplished by leading coordinated efforts with OAIC investigators and research staff. The Specific Aims of the OC are to: (1) provide services to achieve the aims of OAIC-funded and other aging-fo- cused research projects and the infrastructure to support investigators leading these projects; (2) collaborate to improve field, data management and informatics methodologies needed to advance aging-focused research on multifactorial geriatric conditions and to foster the development of the next generation of aging-focused investi- gators; and (3) conduct innovative Development Projects that advance the mission of the Yale OAIC. During the current funding cycle (2018-present), the OC provided research support for 16 OAIC-funded projects and 35 External Projects, consulted with 116 Yale investigators on field and data management plans for projects and grant submissions, was awarded NIH supplemental funding to build an innovative suite of soft- ware tools called the Yale Study Support Suite, and collaborated with other Pepper Centers and NIA-spon- sored programs on research projects, delivery of educational seminars, and software dissemination. These OC efforts have resulted in 129 publications and more than 30 extramurally funded grants totaling over $150 mil- lion. During the next funding cycle, the OC will: (1) collaborate on 5 of the 6 proposed REC and PESC projects and 34 of the 40 funded External Projects; (2) mentor new research staff in the OC; (3) refine and adapt ser- vices to meet program needs; (4) advise and support investigators on study operations, reporting, and compli- ance with NIH requirements; (5) broaden the impact of the core by disseminating innovative software products; and (6) enhance our research informatics infrastructure by working with the OAIC Coordinating Center to iden- tify funding sources that will permit the further expansion of the Yale Study Support Suite (YES3). The YES3 software will serve as an integral part of study operations support for OAIC projects, and with continued expan- sion through the proposed Development Project (DP-1), will provide additional tools for analysis, reporting, and monitoring. The goal of DP-1 is to build the YES3 Datamart REDCap External Module (EM), innovative soft- ware that will integrate with the YES3 Exporter, an EM developed during the current funding cycle. The new Datamart EM will further support analysis, monitoring, and reporting of OAIC studies and will be designed to be compatible with future YES3 components that share data with sponsor and regulatory agencies.

操作核心（OC）通过招募老年人来支持有关多因素的老年病情的研究 多元化和代表的人，与社区的老年人一起成为利益相关者，监视 参与者的安全，提供资源来支持老化研究，设计电子数据收集系统 - 导致高质量数据的TEM，开发软件应用程序以支持研究工作流程和分析， 并收集，准备和报告数据，以说明多因素衰老研究的复杂性。 OC（RC1）的总体目标是确保成功实施多因素衰老研究。 该目标将通过与OAIC研究人员和研究人员进行协调的努力来实现。这 OC的具体目的是：（1）提供服务以实现OAIC资助和其他老龄化的目标 研究了研究项目和基础设施，以支持领导这些项目的研究人员； （2）合作 改善领域，数据管理和信息学方法，以推进以老龄化的研究 多因素的老年病情，并促进下一代以衰老的投资的发展 鳄鱼（3）进行创新的开发项目，以推动耶鲁大学的使命。 在当前的融资周期（2018年至今）中，OC为16个OAIC资助提供了研究支持 项目和35个外部项目，咨询了116名耶鲁大学现场和数据管理计划的调查员 对于项目和赠款提交，被授予NIH补充资金，以建立一套创新的软件套件 称为耶鲁大学研究套件的Ware工具，并与其他胡椒中心和Nia-Spon合作 在研究项目，教育研讨会的交付和软件传播方面讨厌的计划。这些OC 努力导致了129个出版物和30多个外部资助的赠款，总计超过15000万美元 狮子。在下一个资金周期中，OC将：（1）在拟议的REC和PESC项目中的5个合作中合作 和40个资助的外部项目中有34个； （2）OC的指导新研究人员； （3）完善和适应 满足计划需求的恶习； （4）就研究操作，报告和综合建议和支持 NIH要求； （5）通过传播创新软件产品来扩大核心的影响； （6）通过与OAIC协调中心合作到IDEN-来增强我们的研究信息学基础设施 筹集资金来源，将允许进一​​步扩大耶鲁大学研究支持套件（YES3）。是3 软件将作为OAIC项目的研究操作支持的组成部分，并继续扩展 通过拟议的开发项目（DP-1），将为分析，报告和 监视。 DP-1的目的是构建YES3 Datamart Redcap外部模块（EM），创新的软件 将与YES3出口商集成的商品，这是当前资金周期中开发的EM。新的 Datamart EM将进一步支持OAIC研究的分析，监视和报告，并将被设计为 与未来的YES3组件兼容，这些组件与赞助商和监管机构共享数据。