The role of the receptor complex and the cofactors in IGSF10 signaling

受体复合物和辅助因子在 IGSF10 信号传导中的作用

基本信息

批准号：
10728450
负责人：
YUZURU SHIIO
金额：
$ 35.46万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-07 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10728450
关键词：
Basic Science Binding Biological Biological Process Biology C-terminal Cell Line Cell Proliferation Cell Surface Proteins Cell Surface Receptors Cell model Cells Cleidocranial Dysplasia Collaborations Complex Cysteine-Rich Domain Delayed Puberty Ewings sarcoma Foundations Frameshift Mutation Future Gene Expression Glioma Gonadotropin Hormone Releasing Hormone Growth Human Immunoglobulins Inherited Knowledge Leucine-Rich Repeat Ligands Link Malignant neoplasm of lung Mediating Microglia Molecular Mus Mutation N-terminal National Institute of Neurological Disorders and Stroke Neurons Pathologic Pathologic Processes Pathway interactions Phenocopy Physiological Pituitary Hormones Play Protein Secretion Protein Tyrosine Kinase Proteomics RET inhibition Research Role Signal Pathway Signal Transduction Structure System Testing Therapeutic Tissues United States National Institutes of Health Variant cofactor hormone deficiency immunoglobulin receptor inhibitor kinase inhibitor knock-down malignant breast neoplasm member migration mutant novel olfactomedin prevent protein function proto-oncogene protein c-ret receptor skeletal disorder transcriptome sequencing tumor

项目摘要

Immunoglobulin superfamily member 10 (IGSF10) is a large, secreted protein implicated in multiple biological and pathological processes: IGSF10 mutations are associated with hereditary delayed puberty. Low IGSF10 expression is linked to more aggressive lung and breast cancers. A frameshift mutation in IGSF10 was found in a case of a hereditary skeletal disorder, Cleidocranial Dysplasia. IGSF10 A1672T variant was found in combined pituitary hormone deficiency. However, the mechanism of action of IGSF10 is unknown. The applicant’s group identified the cell surface receptor for IGSF10 and the downstream signaling pathway regulated by IGSF10. They also identified a putative co-receptor and a secreted co-factor for IGSF10. This project is directed towards understanding the roles of the receptor complex and the cofactors in IGSF10 signaling. The successful completion of the project will uncover the molecular mechanisms and the biological roles of the novel signaling pathway mediated by IGSF10. The knowledge gained from this project will lay the foundation for understanding the physiological roles of this novel signaling pathway as well as the pathological conditions associated with the dysregulation of this pathway.

免疫球蛋白超家族成员 10 (IGSF10) 是一种大型分泌蛋白，与多种生物和病理过程：IGSF10 突变与遗传性低 IGSF10 青春期延迟有关。 IGSF10 的表达与更具侵袭性的肺癌和乳腺癌有关。在合并症中发现了一例遗传性骨骼疾病——锁骨颅骨发育不良。然而，IGSF10 的作用机制尚不清楚。申请人团队鉴定了IGSF10的细胞表面受体及其下游信号通路他们还鉴定了 IGSF10 的假定辅助受体和分泌辅助因子。该项目旨在了解 IGSF10 中受体复合物和辅因子的作用该项目的成功完成将揭示分子机制和生物学机制。 IGSF10 介导的新型信号通路的作用将从该项目中获得的知识奠定基础。为理解这种新型信号通路的生理作用以及病理作用奠定了基础与该途径失调相关的病症。