A Pilot Feasibility Study of an Intervention to Decrease Overtreatment of Low-risk Thyroid Cancer
减少低危甲状腺癌过度治疗的干预措施试点可行性研究
基本信息
- 批准号:10729147
- 负责人:
- 金额:$ 8.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAmericanAwardAwarenessBehaviorBehavior TherapyCancer SurvivorCaregiversClinicClinic VisitsClinicalClinical TrialsCollaborationsCommunicationCommunitiesConsultDataData CollectionDecision MakingDeimplementationDiagnosisExpectancyFatigueFeasibility StudiesFutureGoalsHealthHealth systemIndividualInterventionIntervention StudiesInterviewKnowledgeLanguageLongevityMalignant NeoplasmsMalignant neoplasm of thyroidMeasuresMethodologyMissionMorbidity - disease rateOperative Surgical ProceduresOutcomePapillary thyroid carcinomaParticipantPatient PreferencesPatientsPilot ProjectsPositioning AttributeProceduresProcessProtocols documentationProviderQualifyingQuality of lifeRandomizedRandomized, Controlled TrialsReadinessRecommendationRecording of previous eventsRecurrenceResearchRiskSelf EfficacySideSiteStructureSurgeonSurvivorsTestingThyroid GlandThyroidectomyTimeVisitVocal Cord ParalysisWorkacceptability and feasibilitycancer carecare costscohortcostdisabilityevidence baseexperienceimprovedinnovationintervention effectmultidisciplinarynovelovertreatmentpragmatic efficacy trialprimary outcomepsychosocialrecruitsecondary outcomeshared decision makingsocial cognitive theorytherapy designtreatment as usualtreatment choicetreatment riskultrasounduptake
项目摘要
PROJECT SUMMARY
Nearly 90% of patients with low-risk papillary thyroid cancer undergo total thyroidectomy, the treatment option
with the greatest morbidity, even though less invasive options offer equivalent recurrence and survival.
Overtreatment of these patients results in significant patient harm and substantial costs. Currently, patients
have unmet informational needs that contribute to the uptake of total thyroidectomy. Patients with low-risk
papillary thyroid cancer would benefit from an intervention that meets their informational needs and increases
their ability to participate in the decision-making process. This proposal is a key step to support our longer-term
goal of reducing overtreatment of low-risk thyroid cancer by intervening on surgical decision making.
Our research team developed a novel intervention called CQUPLE, which includes (1) a Chart of side-by-side,
evidence-based information comparing all three management options for low-risk thyroid cancer, including
expected outcomes and (2) a Question Prompt List that contains key questions to consider asking the
surgeon. The intervention is grounded in social cognitive theory and aims to increase patient awareness of
treatment options and their outcomes, patient activation, and self-efficacy for decision making. This proposal
will pilot CQUPLE at three clinic sites in a single health system. We propose a pilot feasibility randomized
controlled trial in 50 patients with low-risk papillary thyroid cancer to evaluate the feasibility and acceptability of
CQUPLE (Aim 1) and characterize the distribution of outcomes (Aim 2).
The results of the proposed research will provide the preliminary data necessary to prepare for a future, large-
scale pragmatic efficacy trial to test the effect of CQUPLE on patients’ choice for total thyroidectomy. CQUPLE
is a low-cost, scalable, patient-directed intervention that is innovative because it combines two complimentary
components that work to meet patients’ informational and decisional needs through different mechanisms. The
research is significant because reducing rates of total thyroidectomy for patients with low-risk thyroid cancer
has the potential to decrease patient harm and improve long-term outcomes. Our multidisciplinary team’s
history of successful collaboration and experience in behavioral intervention design and testing with
randomizes controlled trials make us well positioned to achieve the aims of this award.
项目概要
近 90% 的低危甲状腺乳头状癌患者接受甲状腺全切除术,这是一种治疗选择
尽管侵入性较小的选择可提供同等的复发率和生存率,但其发病率最高。
目前,对这些患者的过度治疗会导致严重的患者伤害和巨额费用。
未满足的信息需求有助于低风险患者接受甲状腺全切除术。
乳头状甲状腺癌将受益于满足其信息需求并增加其信息需求的干预措施
他们参与决策过程的能力是支持我们长期发展的关键一步。
通过干预手术决策来减少低风险甲状腺癌的过度治疗。
我们的研究团队开发了一种名为 CQUPLE 的新颖干预措施,其中包括 (1) 并排图表,
比较低风险甲状腺癌的所有三种治疗方案的循证信息,包括
预期结果和 (2) 问题提示列表,其中包含需要考虑询问的关键问题
外科医生的干预以社会认知理论为基础,旨在提高患者的意识。
治疗方案及其结果、患者的积极性以及决策的自我效能。
将在单一卫生系统的三个诊所试点 CQUPLE 我们提出了随机试点的可行性。
在 50 名低危甲状腺乳头状癌患者中进行的对照试验,以评估该方案的可行性和可接受性
CQUPLE(目标 1)并描述结果的分布(目标 2)。
拟议研究的结果将为未来的大规模研究提供必要的初步数据。
规模实用疗效试验,测试 CQUPLE 对患者选择 CQUPLE 的影响。
是一种低成本、可扩展、以患者为导向的干预措施,具有创新性,因为它结合了两种互补的方法
通过不同机制满足患者信息和决策需求的组件。
这项研究意义重大,因为降低了低风险甲状腺癌患者的甲状腺全切除率
有潜力减少患者伤害并改善我们的多学科团队的长期结果。
在行为干预设计和测试方面的成功合作历史和经验
随机对照试验使我们能够很好地实现该奖项的目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan C Pitt其他文献
Assessing Fear of Thyroid Cancer in the General U.S. Population: A Cross-Sectional Study.
评估美国普通人群对甲状腺癌的恐惧:一项横断面研究。
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:6.6
- 作者:
Stephanie R Taylor;Alexander S Chiu;Ines Hoxha;Megan C. Saucke;Catherine B. Jensen;Susan C Pitt - 通讯作者:
Susan C Pitt
Susan C Pitt的其他文献
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{{ truncateString('Susan C Pitt', 18)}}的其他基金
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
情绪对低风险甲状腺癌治疗决策的影响
- 批准号:
10790089 - 财政年份:2018
- 资助金额:
$ 8.4万 - 项目类别:
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
情绪对低风险甲状腺癌治疗决策的影响
- 批准号:
10443661 - 财政年份:2018
- 资助金额:
$ 8.4万 - 项目类别:
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
情绪对低风险甲状腺癌治疗决策的影响
- 批准号:
10206057 - 财政年份:2018
- 资助金额:
$ 8.4万 - 项目类别:
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