A Pilot Feasibility Study of an Intervention to Decrease Overtreatment of Low-risk Thyroid Cancer
减少低危甲状腺癌过度治疗的干预措施试点可行性研究
基本信息
- 批准号:10729147
- 负责人:
- 金额:$ 8.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAmericanAwardAwarenessBehaviorBehavior TherapyCancer SurvivorCaregiversClinicClinic VisitsClinicalClinical TrialsCollaborationsCommunicationCommunitiesConsultDataData CollectionDecision MakingDeimplementationDiagnosisExpectancyFatigueFeasibility StudiesFutureGoalsHealthHealth systemIndividualInterventionIntervention StudiesInterviewKnowledgeLanguageLongevityMalignant NeoplasmsMalignant neoplasm of thyroidMeasuresMethodologyMissionMorbidity - disease rateOperative Surgical ProceduresOutcomePapillary thyroid carcinomaParticipantPatient PreferencesPatientsPilot ProjectsPositioning AttributeProceduresProcessProtocols documentationProviderQualifyingQuality of lifeRandomizedRandomized, Controlled TrialsReadinessRecommendationRecording of previous eventsRecurrenceResearchRiskSelf EfficacySideSiteStructureSurgeonSurvivorsTestingThyroid GlandThyroidectomyTimeVisitVocal Cord ParalysisWorkacceptability and feasibilitycancer carecare costscohortcostdisabilityevidence baseexperienceimprovedinnovationintervention effectmultidisciplinarynovelovertreatmentpragmatic efficacy trialprimary outcomepsychosocialrecruitsecondary outcomeshared decision makingsocial cognitive theorytherapy designtreatment as usualtreatment choicetreatment riskultrasounduptake
项目摘要
PROJECT SUMMARY
Nearly 90% of patients with low-risk papillary thyroid cancer undergo total thyroidectomy, the treatment option
with the greatest morbidity, even though less invasive options offer equivalent recurrence and survival.
Overtreatment of these patients results in significant patient harm and substantial costs. Currently, patients
have unmet informational needs that contribute to the uptake of total thyroidectomy. Patients with low-risk
papillary thyroid cancer would benefit from an intervention that meets their informational needs and increases
their ability to participate in the decision-making process. This proposal is a key step to support our longer-term
goal of reducing overtreatment of low-risk thyroid cancer by intervening on surgical decision making.
Our research team developed a novel intervention called CQUPLE, which includes (1) a Chart of side-by-side,
evidence-based information comparing all three management options for low-risk thyroid cancer, including
expected outcomes and (2) a Question Prompt List that contains key questions to consider asking the
surgeon. The intervention is grounded in social cognitive theory and aims to increase patient awareness of
treatment options and their outcomes, patient activation, and self-efficacy for decision making. This proposal
will pilot CQUPLE at three clinic sites in a single health system. We propose a pilot feasibility randomized
controlled trial in 50 patients with low-risk papillary thyroid cancer to evaluate the feasibility and acceptability of
CQUPLE (Aim 1) and characterize the distribution of outcomes (Aim 2).
The results of the proposed research will provide the preliminary data necessary to prepare for a future, large-
scale pragmatic efficacy trial to test the effect of CQUPLE on patients’ choice for total thyroidectomy. CQUPLE
is a low-cost, scalable, patient-directed intervention that is innovative because it combines two complimentary
components that work to meet patients’ informational and decisional needs through different mechanisms. The
research is significant because reducing rates of total thyroidectomy for patients with low-risk thyroid cancer
has the potential to decrease patient harm and improve long-term outcomes. Our multidisciplinary team’s
history of successful collaboration and experience in behavioral intervention design and testing with
randomizes controlled trials make us well positioned to achieve the aims of this award.
项目摘要
近90%的低风险甲状腺甲状腺癌患者进行了总甲状腺切除术,该治疗选择
尽管发病率最高,尽管侵入性较低的选择提供了同等的复发和生存。
这些患者的过度治疗导致严重的患者伤害和大量成本。目前,患者
有未满足的信息需求,有助于甲状腺全切除术的摄取。低风险的患者
甲状腺乳头状癌将受益于满足其信息需求并增加的干预措施
他们参加决策过程的能力。该建议是支持我们的长期的关键步骤
通过介入手术决策来减少低风险甲状腺癌过度治疗的目标。
我们的研究团队开发了一种名为CQUPLE的新颖干预措施,其中包括(1)并排图表,
基于证据的信息,比较了低风险甲状腺癌的所有三种管理选项,包括
预期结果和(2)一个问题提示列表,其中包含要考虑询问的关键问题
外科医生。干预措施基于社会认知理论,旨在提高患者对
治疗方案及其结果,患者激活以及决策的自效。这个建议
将在一个卫生系统的三个诊所地点进行驾驶。我们提出了一个随机的飞行员可行性
50例低风险甲状腺甲状腺癌患者的对照试验,以评估
cquple(AIM 1)并表征结果的分布(AIM 2)。
拟议的研究结果将提供为准备未来大型,大型的初步数据
比例务实的有效性试验,以测试Cquple对患者总甲状腺切除术选择的影响。 cquple
是一种低成本,可扩展性,以患者为导向的干预措施,是创新的,因为它结合了两个免费
通过不同的机制来满足患者的信息和决策需求的组件。
研究很重要,因为低危甲状腺癌患者的甲状腺总切除术率降低
有可能减少患者伤害并改善长期结局。我们的多学科团队
与行为干预设计和测试有关的成功合作和经验的历史
随机化对照试验使我们有好处,以实现该奖项的目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan C Pitt其他文献
Assessing Fear of Thyroid Cancer in the General U.S. Population: A Cross-Sectional Study.
评估美国普通人群对甲状腺癌的恐惧:一项横断面研究。
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:6.6
- 作者:
Stephanie R Taylor;Alexander S Chiu;Ines Hoxha;Megan C. Saucke;Catherine B. Jensen;Susan C Pitt - 通讯作者:
Susan C Pitt
Susan C Pitt的其他文献
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{{ truncateString('Susan C Pitt', 18)}}的其他基金
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
情绪对低风险甲状腺癌治疗决策的影响
- 批准号:
10790089 - 财政年份:2018
- 资助金额:
$ 8.4万 - 项目类别:
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
情绪对低风险甲状腺癌治疗决策的影响
- 批准号:
10443661 - 财政年份:2018
- 资助金额:
$ 8.4万 - 项目类别:
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
情绪对低风险甲状腺癌治疗决策的影响
- 批准号:
10206057 - 财政年份:2018
- 资助金额:
$ 8.4万 - 项目类别:
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