Healthy Cervix: A Clinic Community Health Educator-Based Cervical Cancer Education, Prevention and Screening Program (HEALIX)

健康宫颈：诊所社区健康教育者宫颈癌教育、预防和筛查计划 (HEALIX)

• 批准号: 10772727
• 负责人: PRIMO N. LARA
• 金额: $ 19.71万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10772727
• 关键词: Achievement; Address; Affect; Age; Agriculture; Antineoplastic Agents; Area; Behavior; Biological Sciences; Biomedical Engineering; Businesses; California; Cancer Biology; Cancer Burden; Cancer Control; Cancer Model; Caring; Catchment Area; Cervical Cancer Education; Cervix Uteri; Cessation of life; Client; Clinic; Clinical; Clinical Services; Clinical Trials; Collaborations; Collection; Communication; Communities; Community Health; Community Health Aides; Community Outreach; Comprehensive Cancer Center; Country; County; Coupled; DNA Repair; Diagnosis; Diagnostic; Discipline; Disease; Disparity population; Dissemination and Implementation; Early Diagnosis; Education; Education and Outreach; Educational Models; Engineering; Enrollment; Environmental Science; Equity; Evidence based intervention; Federally Qualified Health Center; Funding; Geographic Locations; Goals; Grant; Health; Health Educators; Health behavior; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Image; Imaging Device; Immunology; Individual; Institution; Intervention; Intervention Studies; Journals; Knowledge; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical Imaging; Metabolism; Microscopic; Mission; Molecular; Multimedia; NCI-Designated Cancer Center; Oncology; Outcome; Palpable; Pap smear; Patients; Population; Positioning Attribute; Positron-Emission Tomography; Prevention; Prevention program; Prevention strategy; Primary Prevention; Productivity; Prunus persica; Publications; Publishing; Radio; Recording of previous events; Research; Resources; Rural; Science; Scientist; Screening for cancer; Secure; Services; Signal Transduction; Solid; System; Techniques; Technology; Testing; Time; Training; Underserved Population; United States National Institutes of Health; Universities; Vaccination; Veterinary Medicine; Vision; Vulnerable Populations; Woman; Workforce Development; cancer education; cancer health disparity; cancer risk; career development; cervical cancer prevention; community clinic; community engaged research; community engagement; community setting; comparative; disparity reduction; economic disparity; ethnic disparity; ethnic diversity; health care delivery; health equity; implementation outcomes; improved; innovation; insight; medical schools; member; neighborhood disadvantage; novel; outcome disparities; prevent; primary care team; programs; racial diversity; racial population; risk mitigation; satisfaction; screening; screening guidelines; screening program; social disparities; system-level barriers; tobacco control; treatment as usual; treatment trial; vaccine acceptance; women of color

PROJECT SUMMARY Widespread use of the human papilloma virus (HPV) vaccine coupled with early detection is expected to reduce the cervical cancer burden across all racial/ethnic groups and mitigate disparities as women of color are disproportionately affected by cervical cancer. To address the current dearth of effective preventative programs embedded within the community health clinic system, where most of the underserved populations receive care, we developed the Healthy Cervix program, a community clinic health educator-based cervical cancer education, prevention and screening effort, (“HEALIX”) built as a community engaged research collaboration between the University of California, Davis Comprehensive Cancer Center and Peach Tree Health (Peach Tree), a Federally Qualified Health Center (FQHC). HEALIX is grounded in a multilevel health equity framework merging a community health worker-led outreach and education model approach with cervical cancer training for primary care teams, and the option of both HPVself-collectionand clinical Papanicolaou (Pap) testing for clients/patients. The primary goal of this study is to evaluate the acceptability, appropriateness, and feasibility of implementing this multilevel intervention, which addresses individual, community, and systems level barriers, on increasing HPV completion rates among patients ages 9-17 and Pap testing among women ages 21-65 in three of Peach Tree’s clinics compared to usual care. This will be accomplished through the following aims: Aim 1) Customize and contextualize cervical cancer prevention communications, education strategies and multi-media delivery modes that will inform necessary adaptations to the proposed multilevel intervention; and Aim 2) Pilot the HEALIX multilevel intervention in three Peach Tree clinics, evaluating selected implementation outcomes and exploring service (screening/vaccination rates) and client/patient (satisfaction) outcomes. The proposed research is significant because it will contribute to the field of multilevel intervention research to mitigate cervical cancer disparities and addresses the need for more scientifically rigorous, evidence-based interventions that can be disseminated and implemented in diverse communities. Successful achievement of our Aims will significantly increase HPV vaccination and Pap testing rates over baseline, advance our understanding of the utility of HPV self-collection kits in community settings; and will provide insights on strategies that can be utilized to address other cancer health disparities impacting women. Furthermore, given the paucity of effective multilevel interventions to increase HPV vaccine uptake and Pap testing in understudied, underrepresented, and underreported communities, this study can guide effective dissemination and implementation of empirically derived evidence-based interventions for health care delivery systems serving rural, racially/ethnically diverse, and socially disadvantaged communities.

项目概要 人乳头瘤病毒 (HPV) 疫苗的广泛使用加上早期检测预计将减少 所有种族/族裔群体的宫颈癌负担以及减少有色人种女性的差异 解决当前受宫颈癌死亡影响的有效预防方案。 嵌入社区卫生诊所系统，大多数服务不足的人群在那里得到护理， 我们开发了健康子宫颈计划，这是一个基于社区诊所健康教育者的子宫颈癌教育， 预防和筛查工作（“HEALIX”）作为社区参与的研究合作而建立 加州大学戴维斯分校综合癌症中心和联邦桃树健康中心 (Peach Tree) 合格健康中心 (FQHC) 以多层次健康公平框架为基础，融合了 社区卫生工作者主导的外展和教育模式方法，为初级儿童提供宫颈癌培训 护理团队，以及为客户/患者提供 HPV 自我采集和临床巴氏 (Pap) 检测的选项。 本研究的主要目的是评估实施的可接受性、适当性和可行性 这种多层次的干预措施解决了个人、社区和系统层面的障碍， 桃子中 9-17 岁患者的 HPV 完成率和 21-65 岁女性的巴氏涂片检查完成率 Tree 的诊所与常规护理相比，这将通过以下目标来实现： 目标 1) 定制。 并结合宫颈癌预防沟通、教育策略和多媒体传播的背景 为拟议的多层次干预措施进行必要的调整提供信息的模式；以及 目标 2) 试点 HEALIX 对三个 Peach Tree 诊所进行多层次干预，评估选定的实施结果并 探索服务（筛查/疫苗接种率）和客户/患者（满意度）结果。 拟议的研究意义重大，因为它将有助于多层次干预研究领域 缩小宫颈癌差异并满足更科学严谨、基于证据的需求 可以在不同社区传播和实施的干预措施。 目标将显着提高 HPV 疫苗接种率和巴氏涂片检测率（高于基线），增进我们的了解 HPV 自我采集试剂盒在社区环境中的实用性，并将提供有关可采取的策略的见解； 此外，由于缺乏有效性，该方法被用来解决影响妇女的其他癌症健康差异。 多层次干预措施，以增加 HPV 疫苗的接种率，并在未充分研究、代表性不足和 报告不足的社区，这项研究可以指导有效的传播和实施 针对为农村、种族/民族多样化、 和社会弱势群体。

项目成果

Nanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo.

纳米紫杉醇和 AZD9291 可协同消除体内非小细胞肺癌。

• DOI: 10.2217/nnm-2017-0355
• 发表时间: 2018-05-01
• 期刊: Nanomedicine
• 影响因子: 5.5
• 作者: Xinshuai Wang;Li Zhang;Xiaocen Li;De;Xiao;Xue;Jun;M. Zhao;Yixuan He;K. Lam;Shenshuo Gao;Tzu;Yuanpei Li
• 通讯作者: Yuanpei Li

A phase I dose escalation, dose expansion and pharmacokinetic trial of gemcitabine and alisertib in advanced solid tumors and pancreatic cancer.

吉西他滨和阿利替布治疗晚期实体瘤和胰腺癌的 I 期剂量递增、剂量扩展和药代动力学试验。

• 发表时间: 2022-09
• 影响因子: 3
• 作者: Chen, Justin A;Huynh, Jasmine C;Wu, Chun;Yu, Ai;Matsukuma, Karen;Semrad, Thomas J;Gandara, David R;Li, Tianhong;Riess, Jonathan W;Tam, Kit;Mack, Philip C;Martinez, Anthony;Mahaffey, Nichole;Kelly, Karen L;Kim, Edward J
• 通讯作者: Kim, Edward J

Phototherapy with Cancer-Specific Nanoporphyrin Potentiates Immunotherapy in Bladder Cancer.

癌症特异性纳米卟啉光疗可增强膀胱癌的免疫治疗。

• 发表时间: 2022-11-01
• 作者: Zhu, Zheng;Ma, Ai;Zhang, Hongyong;Lin, Tzu;Xue, Xiangdong;Farrukh, Hizra;Zhu, Shaoming;Shi, Wei;Yuan, Ruan;Cao, Zhixiu;Chittepu, Veera Chandra Sekhar Reddy;Prabhala, Rao;Li, Yuanpei;Lam, Kit S;Pan, Chong
• 通讯作者: Pan, Chong

Evaluation of the use of a novel bioabsorbable polymer drug-eluting microsphere for transarterial embolization of hepatocellular neoplasia in dogs.

新型生物可吸收聚合物药物洗脱微球用于犬肝细胞肿瘤经动脉栓塞的评价。

• 发表时间: 2022
• 影响因子: 3.7
• 作者: Culp, William T N;Johnson, Eric G;Giuffrida, Michelle A;Rebhun, Robert B;Cawthra, James K;Schwanz, Heidi A;Burton, Jenna H;Kent, Michael S
• 通讯作者: Kent, Michael S

Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair.

具有高胶原蛋白结合亲和力的工程化细胞外囊泡在组织修复中表现出优异的原位保留和治疗功效。

• 发表时间: 2022
• 影响因子: 12.4
• 作者: Hao, Dake;Lu, Lu;Song, Hengyue;Duan, Yixin;Chen, Jianing;Carney, Randy;Li, Jian Jian;Zhou, Ping;Nolta, Jan;Lam, Kit S;Leach, J Kent;Farmer, Diana L;Panitch, Alyssa;Wang, Aijun
• 通讯作者: Wang, Aijun