Paul Calabresi Career Development Award for Clinical Oncology (K12) at UC Davis

加州大学戴维斯分校临床肿瘤学 (K12) Paul Calabresi 职业发展奖

基本信息

批准号：
9336795
负责人：
PRIMO N. LARA
金额：
$ 80.36万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9336795
关键词：
Automobile Driving Basic Science Cancer Patient Center for Translational Science Activities Clinical Clinical Oncology Clinical Oncology Supplement (K12)Clinical Research Clinical Skills Clinical Trials Communication Competence Comprehensive Cancer Center Custom Development Devices Ensure Environment Ethics Evaluation Faculty FarGo Funding Goals Grant Investigation K-Series Research Career Programs Language Malignant Neoplasms Mentors Mentorship New Agents Patients Program Development Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Training SECTM1 gene Science Scientist Time Training Translational Research Vision Writing base cancer clinical trial career career development clinical investigation didactic education drug development drug discovery evidence base improved outcome innovation interest medical schools multidisciplinary oncology patient oriented patient oriented research programs research and development skills success translational scientist

项目摘要

DESCRIPTION (provided by applicant): The overarching goal of the UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development Program (CDP; PI, Primo Lara, Jr. MD) is to nurture clinician or basic-translational junior faculty to become independent, patient-oriented cancer researchers who are highly trained in translational, team-driven research. Using 1) core competencies, 2) advanced oncology coursework, 3) career development, 4) mentored research, and 5) cross-cultural exposure, the CDP provides two new scholars per year (six at any one time) with training aimed at honing ideas and skills that go far beyond their initial disciplinary boundaries. Scholars will overcome language and cultural barriers that typically exist between clinical and basic-translational researchers, take advantage of the collaborative research environment at UC Davis, participate in multidisciplinary and translational forums, and gather essential skills in research design, clinical trial development, team science, grant writing ethical conduct of research, communication, and career development. The vision is to enhance translational research by training clinician researchers to incorporate and utilize basic/correlatie science in their pursuit of clinical trials ("Clinical Track"), and conversely, driving basic scienists towards patient-driven drug development and clinical research ("Basic/Translational Track"). To maintain the emphasis on patient- driven clinical research, all CDP scholars, under the mentorship of both a clinical mentor and basic/translational mentor, will be required to develop and initiate/conduct their own investigator-initiated clinical trial during the training period. Th program will leverage the outstanding research, training, and evaluation expertise and infrastructure of the NCI-designated UC Davis Comprehensive Cancer Center, NCATS-funded Clinical and Translational Research Center (CTSC), and School of Medicine Career Development Program. It will be overseen and enhanced by a highly organized internal Oversight Committee and external Advisory Board. Overall, the CDP seeks to accomplish the following specific aims: 1) Offer a competency-based didactic curriculum to promote team science, encourage translational research, and hone essential skills for clinical trial development and career/research success; 2) Oversee individualized patient- oriented research projects customized to the interests and needs of each scholar; and 3) Provide oversight of scholar training to ensure the progressive development of a cadre of fully competent interdisciplinary-oriented researchers who can successfully conduct translational cancer clinical trials with investigational new agents or devices. These specific aims will enable the building of a critical mass of trained researchers at UC Davis at the forefront of innovative, impactful, evidence-based research, who can oversee research that encompasses the entire continuum of research from basic science (target identification and drug discovery) through translational science (drug development and correlative science) to clinical investigation. By doing so, we offer the potential of both enhancing the success of clinician scientists and improving outcomes for cancer patients.

描述（由申请人提供）：加州大学戴维斯分校 Paul Calabresi K12 临床肿瘤学研究职业发展计划（CDP；PI，Primo Lara, Jr. MD）的总体目标是培养临床医生或基础翻译初级教师成为独立、耐心的人面向癌症研究人员，他们在转化、团队驱动的研究方面接受过严格培训，利用 1) 核心能力，2) 高级肿瘤学课程，3) 职业发展，4)。 5）跨文化接触，CDP 每年为两名新学者（每次六名）提供旨在磨练思想的培训，这些培训远远超出了他们最初的学科界限，学者们将克服语言和文化导师技能障碍。通常存在于临床和基础转化研究人员之间，利用加州大学戴维斯分校的协作研究环境，参与多学科和转化论坛，并收集研究设计、试验临床开发、团队科学、资助写作研究道德行为方面的基本技能、沟通和职业其愿景是通过培训临床研究人员在临床试验（“临床轨道”）中融入和利用基础/相关科学来加强转化研究，反过来，推动基础科学家走向以患者为导向的药物开发和临床研究（为了保持对患者驱动的临床研究的重视，所有 CDP 学者都需要在临床导师和基础/转化导师的指导下开发和启动/开展自己的研究。 Th 项目将利用 NCI 指定的加州大学戴维斯分校综合癌症中心、NCATS 资助的临床和转化研究中心 (CTSC) 以及学校的出色研究、培训和评估专业知识和基础设施。总体而言，CDP 力求实现以下具体目标： 1) 提供基于能力的教学课程。促进团队科学，鼓励转化研究，并磨练临床试验开发的基本技能和职业/研究的成功； 2）监督根据每位学者的兴趣和需求定制的个性化的以患者为导向的研究项目；以及 3）对学者培训进行监督，以确保逐步发展一支完全有能力的跨学科研究人员队伍；这些具体目标将使加州大学戴维斯分校的临床研究人员能够在创新、有影响力、基于证据的研究的前沿建立起足够数量的训练有素的研究人员，他们可以监督涵盖以下领域的研究。全部的从基础科学（靶点识别和药物发现）到转化科学（药物开发和相关科学）再到临床研究的连续研究，我们提供了潜力。既提高临床科学家的成功，又改善癌症患者的治疗结果。