Infant Immunologic and Neurologic Development following Maternal Infection in Pregnancy during Recent Epidemics

近期流行病期间妊娠期感染后婴儿的免疫和神经系统发育

• 批准号: 10784250
• 负责人: Jae U Jung
• 金额: $ 37万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-24 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10784250
• 关键词: 2019-nCoV; Address; Affect; Age; Americas; Antigens; Area; Awareness; Behavioral; Biological Markers; Birth; Brain; Brazil; COVID-19; COVID-19 pandemic; Cephalic; Child; Child Welfare; Childhood; Clinical; Cognition; Collaborations; Communicable Diseases; Data; Development; Diagnosis; Diagnostic; Discipline of obstetrics; Disease; Disease-Free Survival; Enrollment; Epidemic; Epidemiology; Evaluation; Exposure to; Fetus; Functional disorder; Future; Goals; Growth; Health; Image; Immune; Immune response; Immune system; Immunization; Immunoglobulin M; Immunologics; Immunology; Impairment; Infant; Infection; Inflammatory; Infrastructure; Knowledge; Language; Language Delays; Language Development; Learning; Learning Disabilities; Literature; Longitudinal cohort; Longitudinal cohort study; Maternal-Fetal Transmission; Maternally-Acquired Immunity; Methods; Molecular; Monitor; Mothers; Motor; Neurocognitive Deficit; Neurologic; Neuropathogenesis; Organ; Outcome; Pathogenesis; Patient Recruitments; Perinatal Infection; Personal Satisfaction; Population; Pregnancy; Pregnancy Trimesters; Pregnant Women; Productivity; Prospective cohort; Proteomics; Reporting; Research; Research Personnel; Risk; SARS-CoV-2 infection; School-Age Population; Scientist; Sensory; Severities; T-Lymphocyte; Technology; Time; United States; Vaccines; Vertical Transmission; Viral; Virus; Vulnerable Populations; ZIKA; ZIKV infection; Zika Virus; antenatal; autism spectrum disorder; calcification; chemokine; clinical research site; cohort; congenital infection; congenital zika syndrome; coronavirus disease; early childhood; experience; fetal; global health emergency; hearing impairment; immune activation; immune function; in utero; infant outcome; maternal outcome; multidisciplinary; neurodevelopment; neurological rehabilitation; neurosensory; neutralizing antibody; new outbreak; novel; novel coronavirus; pandemic disease; pathogen; prenatal; programs; response; sample collection; tool; vaccine response; virology

Abstract/Summary The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) saw rapid global spread, leading to a pandemic infection and an unprecedented global health emergency. Just years before, we witnessed the devastating impact of Zika virus (ZIKV) to unborn fetuses in the Americas. This proposal responds to the need to fill critical gaps in the understanding of the clinical repercussions of antenatal infections such as ZIKV and SARS-CoV-2 infection in pregnant women to the developing immune system of their infants, through the evaluation of cellular and humoral immune responses and clinical and neurodevelopmental outcomes following maternal immune activation (MIA) in this vulnerable population. Our team of researchers has been collaborating over the last 7 years to characterize the clinical and cellular effects of in utero transmission of Zika virus (ZIKV), with the collection of specimens from over hundreds of mother- infant pairs from Brazil. We reported on multiple obstetrical and clinical outcomes of infants with congenital ZIKV infection in the literature, including that ZIKV vertical transmission rate is at least 65%, that infected children do not develop ZIKV specific neutralizing antibodies despite an early IgM response, and that maternal humoral immune responses tend to be robust with highly neutralizing activity. During the COVID-19 pandemic we established a cohort of mother-infant pairs at UCLA and Fiocruz, Rio de Janeiro and controls with mother-infant dyads enrolled to date in both places. We are utilizing the existing infrastructure and scientific methods developed in the aftermath of the ZIKV epidemic to further evaluate clinical, cellular humoral and inflammatory parameters predicting immunologic outcomes in infants and children exposed to either maternal ZIKV and SARS Cov2 infection. The main goal of the proposed research is to comprehensively characterize repercussions of MIA on infant immune development and clinical outcomes, with a focus on immune pathogenesis. We include a longitudinal cohort of 200 mother- infant pairs with COVID-19 and 100 healthy control mother-infant pairs in the US and Brazil and 200 mother-infant pairs with ZIKV in Brazil and 100 healthy control pairs at the same clinical sites to address these goals. This RO1 proposes to evaluate the repercussions of MIA on infant well- being and immune development. State of the art technology is used to address the scientific aims, with the research led by experts in the field of immunology, infectious diseases & congenital infections who have ongoing successful, productive partnerships. The data rendered will be crucial for the knowledge of immune pathogenesis in pediatric populations with antenatal viral exposures.

摘要/总结 2019 年新型冠状病毒病（COVID-19）在全球范围内迅速爆发 传播，导致大流行感染和前所未有的全球卫生紧急情况。只是 几年前，我们目睹了寨卡病毒（ZIKV）对未出生胎儿的毁灭性影响 美洲。该提案满足了填补理解中的关键空白的需要。 ZIKV 和 SARS-CoV-2 感染等产前感染对孕妇的临床影响 通过评估细胞和免疫系统，妇女可以了解婴儿免疫系统的发育情况 产后体液免疫反应以及临床和神经发育结果 该弱势群体的免疫激活（MIA）。我们的研究团队已经 在过去的 7 年里合作来描述子宫内的临床和细胞效应 寨卡病毒（ZIKV）的传播，从数百名母亲身上收集了样本 来自巴西的婴儿对。我们报告了患有以下疾病的婴儿的多项产科和临床结果： 文献中记载的先天性 ZIKV 感染，其中 ZIKV 垂直传播率至少为 65% 的人认为，尽管早期就出现了 ZIKV 感染，但受感染的儿童并未产生 ZIKV 特异性中和抗体 IgM 反应，并且母体体液免疫反应在高度 中和活性。在 COVID-19 大流行期间，我们建立了一个母婴队列 在加州大学洛杉矶分校和里约热内卢菲奥克鲁兹配对，并与注册的母婴二人组进行对照 两个地方都可以约会。我们正在利用现有的基础设施和开发的科学方法 在 ZIKV 流行后进一步评估临床、细胞体液和 炎症参数可预测暴露于以下环境的婴儿和儿童的免疫结果 母亲 ZIKV 和 SARS Cov2 感染。拟议研究的主要目标是 全面描述 MIA 对婴儿免疫发育和临床的影响 结果，重点是免疫发病机制。我们包括 200 名母亲的纵向队列 美国和巴西的 100 对健康对照母婴对感染了 COVID-19 的婴儿 巴西 200 对感染 ZIKV 的母婴和同一临床地点的 100 对健康对照 来实现这些目标。该 RO1 建议评估 MIA 对婴儿健康的影响 存在和免疫发育。最先进的技术用于实现科学目标， 由免疫学、传染病和先天性疾病领域的专家领导的研究 感染者拥有持续成功、富有成效的伙伴关系。呈现的数据将是 对于了解产前病毒感染儿科人群的免疫发病机制至关重要 曝光。

项目成果

Infant movement classification through pressure distribution analysis.

通过压力分布分析对婴儿运动进行分类。

• 发表时间: 2023-08-16
• 作者: Kulvicius, Tomas;Zhang, Dajie;Nielsen;Bölte, Sven;Kraft, Marc;Einspieler, Christa;Poustka, Luise;Wörgötter, Florentin;Marschik, Peter B
• 通讯作者: Marschik, Peter B