4/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium

4/5-认知神经科学任务可靠性

• 批准号: 7693696
• 负责人: James M. Gold
• 金额: $ 12.3万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7693696
• 关键词: Activities of Daily Living; Address; Awareness; Characteristics; Clinical; Clinical Investigator; Clinical Trials; Clinical assessments; Cognition; Cognitive; Cognitive deficits; Consensus; Data; Development; Electronics; Ensure; Evaluation; Explosion; Floor; Goals; Human; Impaired cognition; Individual; Knowledge; Laboratories; Lead; Length; Life; Literature; Maintenance; Measurement; Measures; Methods; Modification; Neuropsychological Tests; Neurosciences Research; Outcome; Participant; Patients; Perception; Performance; Process; Property; Psychometrics; Reading; Recording of previous events; Recruitment Activity; Research; Retrieval; Sampling; Schizophrenia; Series; Site; Specialist; Standardization; Task Performances; Testing; Time; Translating; Translation Process; Translations; Validation; Work; base; clinical application; cognitive function; cognitive neuroscience; cognitive system; design; drug development; flexibility; functional outcomes; improved; interest; meetings; process optimization; public health relevance; relating to nervous system; response; success; symposium; theories; translational approach; visual control

DESCRIPTION (provided by applicant): Over the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia. Along with this new awareness has come an increasing emphasis on the importance of developing new treatments that may positively impact these cognitive deficits. During this same period, the cognitive neuroscience field has seen an explosion of technical advances and new knowledge regarding the neural basis of cognition. Sadly, the translation and application of this cutting edge knowledge and paradigm development to new drug development in schizophrenia has lagged significantly behind overall progress in cognitive neuroscience, in large part due to the lack of data on the measurement properties of tasks used in cognitive neuroscience. This concern spawned the Cognitive Neuroscience Research To Improve Cognition in Schizophrenia (CNTRICS) initiative, which conducted a series of conferences designed to develop consensus on the constructs and paradigms from cognitive neuroscience that are ripe for translation, and the validation and psychometric goals when translating such tasks for use in clinical trials contexts. The current application is a logical and needed extension of the CNTRICS initiative that will begin the translation process for paradigms designed to assess four of the constructs identified as being ripe for translation in the first CNTRICS meeting. We have brought together a collaborative "translation" team that represents significant expertise from the many fields necessary for the success of this endeavor, including both basic and clinical cognitive neuroscientists, psychometricians, and clinical trials specialists. We have chosen to focus on four constructs that span both early (gain control and visual integration in perception) and higher-level (goal maintenance, relational encoding and retrieval) components of human cognitive processing. By examining multiple mechanisms, we will be able to establish the generality of the translational approach we propose across different levels and types of cognitive mechanisms. Specific Aim 1 is to validate (in both individuals with schizophrenia and comparison participants) optimized versions of the paradigms that assess our four constructs of interest, as well as to examine the relationship of task performance to clinical and functional outcomes in schizophrenia. By optimization, we mean examining modifications on already validated paradigms that are designed to: 1) minimize task length; 2) simplify task administration across multiple sites; 3) maximize sensitivity and selectivity in assessing the specific cognitive mechanisms of interest; and 4) enhance reliability and minimize floor and ceiling effects. By validation, we mean ensuring that such optimizations designed to enhance the psychometric properties of the task do not alter its construct validity. Specific Aim 2 will be to assess and optimize test-retest reliability and practice effects for the task versions validated in Specific Aim 1. PROJECT NARRATIVE This project has high relevance for public health by significantly improving our ability to translate paradigms developed into the basic cognitive neuroscience literature for use in clinical trials aimed at improving cognition in schizophrenia. Cognitive deficits in schizophrenia are a major predictor of functional outcome in this debilitating illness. Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives.

描述（由申请人提供）：在过去的十年中，人们对精神分裂症患者认知受损的残疾影响的认识越来越多。随着这种新的认识，人们越来越强调开发新疗法的重要性，这些新疗法可能会对这些认知缺陷产生积极影响。在同一时期，认知神经科学领域已经爆炸了有关认知神经基础的技术进步和新知识。可悲的是，这种尖端知识和范式发展对精神分裂症的新药物开发的翻译和应用显着落后于认知神经科学的总体进步，这在很大程度上是由于缺乏有关认知神经科学任务的测量特性的数据。这种担忧产生了认知神经科学研究，以改善精神分裂症（CNTRICS）倡议的认知性，该计划进行了一系列会议，旨在在认知神经科学的结构和范式上建立共识，这些构建和范式是翻译的验证和心理目标，在翻译此类任务进行临床试验中的验证和心理目标。当前的应用程序是CNTRICS计划的逻辑且需要扩展，该计划将开始针对第一次CNTRICS会议中评估四个构造的范式的翻译过程。我们汇集了一个合作的“翻译”团队，该团队代表了这项努力成功所必需的许多领域的重要专业知识，包括基本和临床认知神经科学家，心理学家和临床试验专家。我们选择专注于跨越早期（感知中的获得控制和视觉整合）和人类认知处理的高级（目标维护，关系编码和检索）组件的四个结构。通过检查多种机制，我们将能够确定我们在不同层次和认知机制的类型上提出的翻译方法的通用性。具体目的1是验证（在精神分裂症和比较参与者中）优化范式的版本，以评估我们的四种感兴趣的构建体，并检查精神分裂症的任务绩效与临床和功能结果的关系。通过优化，我们的意思是检查针对已验证的范例的修改，该范例旨在：1）最小化任务长度； 2）简化跨多个站点的任务管理； 3）在评估感兴趣的特定认知机制方面最大程度地提高灵敏度和选择性； 4）提高可靠性并最大程度地减少地板和天花板效应。通过验证，我们的意思是确保旨在增强任务心理测量特性的这种优化不会改变其构造有效性。特定目标2将是评估和优化针对特定目标验证的任务版本的测试 - 重测可靠性和实践效果。项目叙述这一项目与公共卫生具有很高的相关性，通过显着提高了我们将转化为基本认知神经科学文献转化为临床试验中的基本认知神经科学文献的能力，以改善Schizizophrenia的认知。精神分裂症的认知缺陷是这种使人衰弱的疾病中功能结果的主要预测指标。因此，我们需要改善我们在精神分裂症中检测和增强认知功能的方法，以帮助患有这种疾病的人带来更具富有成效和充实的生活。