Menopausal Transition in Women with Spinal Cord Injury

脊髓损伤女性的更年期过渡

基本信息

批准号：
7552023
负责人：
CLAIRE Zabelle KALPAKJIAN
金额：
$ 10.06万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-01-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7552023
关键词：
Academy Address Age Agreement Ally American Anatomy Area Award Behavioral Biological Biological Process Biometry Cardiovascular Diseases Cardiovascular system Chairperson Clinic Clinical Clinical Management Clinical Research Commit Communities Complementary and alternative medicine Control Groups Data Databases Development Development Plans Enrollment Epidemiology Exercise Physiology Faculty Family Physicians Fellowship Functional disorder Funding Future Goals Grant Health Health Policy Hormonal Hormone replacement therapy Impairment Institutes Institution Investigation Knowledge Laboratories Letters Longitudinal Surveys Menopausal Symptom Menopause Menstruation Mentors Methodology Michigan Morbidity - disease rate National Center for Complementary and Alternative Medicine Nature Outcome Outpatients Ovarian Physical Medicine Physiological Physiology Preparation Principal Investigator Process Psychosocial Factor Public Health Schools Qualitative Methods Qualitative Research Randomized Clinical Trials Recommendation Records Rehabilitation Research Rehabilitation therapy Research Research Design Research Methodology Research Personnel Research Project Grants Research Training Resources Risk Role Schools Scientific Advances and Accomplishments Scientist Series Severities Spinal cord injury Surveys Symptoms Testing Time Training Training Programs Underserved Population United States National Institutes of Health Universities Woman Women&apos s Health Writing body system career career development case control cohort college design disability experience lectures longitudinal design medical schools meetings men next generation prevent programs public health research responsible research conduct risk benefit ratio skills social

项目摘要

DESCRIPTION (provided by applicant): The purpose of this application is to enable this candidate to become an independent research scientist by providing an intensive, supervised career development experience in the investigation of the moderating role of mobility impairment, specifically spinal cord injury (SCI) on the relationship of menopause and physical and behavioral outcomes. Guiding this career development plan are the candidate's co-mentors, accomplished investigators in menopause, SCI and rehabilitation research with well-established track records as successful, independent NIH investigators. This award will provide the candidate with advanced scientific training in the conduct of clinical research trials by enrolling in a two-year K30 Training Program in Clinical Research, with additional coursework in the School of Public Health and the Institute for Social Research at the University of Michigan. Coursework will include cohort and case-controlled designs, randomized clinical trials, survey research, health policy, epidemiological research, biostatistics, qualitative methods and training in the responsible conduct of research. Training in the clinical and biological aspects of SCI includes a SCI Fellowship Lectures Series in the anatomy and pathophysiology of SCI and weekly SCI physiology lab meetings. This plan also provides the candidate with an opportunity to conduct a preliminary research project reflecting her long-term career goals. Research recommendations of NIH Office of Research on Women's Health for addressing the needs of underserved populations are reflected in these proposed studies. Using longitudinal survey and physiological data, three studies are designed to test the general hypothesis that SCI will moderate the impact of menopause by potentiating its negative effects on physical, behavioral and physiological outcomes. Non-disabled women and men with SCI will serve as important control groups to distinguish the effects of SCI on menopause and menopause on SCI using a longitudinal design. Study 1 will determine the occurrence and severity of menopause symptoms and their impact on secondary conditions and behavioral outcomes in women with SCI. Study 2 will determine the effect of menstruation cessation on physiological outcomes in women with SCI. Using a phenomenological tradition of qualitative methodology, Study 3 will explore the experience of menopause in women with SCI from a personal perspective. This proposed research will be conducted at an academic institution with a well established GCRC, Center for Excellence in Women's Health, SCI Exercise Physiology Laboratory, outpatient SCI clinics, and access to national databases for SCI. Findings will be used to write an R03 application during training in preparation for submission of an R01 application during year 5 of training.

描述（由申请人提供）：本申请的目的是通过在调查移动性障碍的调节作用，特别是脊髓损伤（SCI）对更年期和身体和行为抗果关系的关系的调查中，使该候选人成为一名独立的研究科学家。指导这一职业发展计划是候选人的联合收取者，在更年期，SCI和康复研究方面有成就的调查员，并拥有完善的往绩记录，作为成功的独立NIH调查人员。该奖项将通过参加为期两年的K30临床研究培训计划，为临床研究试验的进行高级科学培训，并在公共卫生学院和密歇根大学的社会研究所提供其他课程。课程将包括队列和病例控制的设计，随机临床试验，调查研究，卫生政策，流行病学研究，生物统计学，定性方法和负责任的研究进行培训。 SCI的临床和生物学方面的培训包括SCI奖学金讲座系列SCI的解剖学和病理生理学和每周SCI生理实验室会议。该计划还为候选人提供了一个机会，可以开展一个反映她长期职业目标的初步研究项目。 NIH关于满足服务不足人群需求的NIH研究办公室的研究建议反映在这些拟议的研究中。使用纵向调查和生理数据，三项研究旨在检验总体假设，即SCI将通过增强其对物理，行为和生理结果的负面影响来减轻更年期的影响。具有SCI的非障碍男女将用作重要的对照组，以使用纵向设计来区分SCI对更年期和更年期对SCI的影响。研究1将确定更年期症状的发生和严重程度及其对SCI女性的次要疾病和行为结果的影响。研究2将确定月经停止对SCI女性生理结果的影响。研究3利用定性方法论的现象学传统，将从个人角度探索SCI女性更年期的经验。这项拟议的研究将在一个学术机构，良好的GCRC，妇女健康卓越中心，SCI运动生理实验室，门诊SCI诊所以及进入SCI国家数据库的访问权限。调查结果将用于在培训期间编写R03申请，以准备在培训的第5年提交R01申请。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Menopause characteristics and subjective symptoms in women with and without spinal cord injury.

有和没有脊髓损伤的女性的更年期特征和主观症状。

DOI：
10.1016/j.apmr.2009.12.012
发表时间：
2010
期刊：
Archives of physical medicine and rehabilitation
影响因子：
4.3
作者：
Kalpakjian,ClaireZ;Quint,ElisabethH;Bushnik,Tamara;Rodriguez,GiannaM;Terrill,MelissaSendroy
通讯作者：
Terrill,MelissaSendroy