Early intervention as a determinant of hearing aid benefit for age-related hearing loss: Results from longitudinal cohort studies

早期干预是助听器对年龄相关性听力损失有益的决定因素：纵向队列研究的结果

• 批准号: 10749385
• 负责人: Lauren Kay Dillard
• 金额: $ 7.61万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749385
• 关键词: Address; Adult; Age; Aging; Apple; Audiology; Chronic; Clinical; Clinical Trials; Cognition; Cognitive; Cohort Studies; Communication; Communities; Data; Development; Diagnosis; Early Intervention; Educational process of instructing; Engineering; Environment; Epidemiology; Funding; Future; General Population; Goals; Health; Health Personnel; Health Promotion; Hearing; Hearing Aids; Individual; Intervention; Knowledge; Longitudinal cohort study; Measures; Medical; Medicine; Mentors; Methods; National Institute on Deafness and Other Communication Disorders; Neuronal Plasticity; Outcome; Participant; Population Study; Presbycusis; Public Health; Randomized, Controlled Trials; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Sampling; Secondary Prevention; Severities; South Carolina; Speech; Strategic Planning; Surveys; Testing; Time; Training; United States National Academy of Sciences; United States National Institutes of Health; Universities; Work; career; clinical practice; cognitive function; dalton; epidemiology study; evidence base; follow-up; frailty; hearing impairment; help-seeking behavior; human old age (65+); improved; population based; prospective; psychosocial; psychosocial wellbeing; public health priorities; public health research; screening; tertiary prevention; uptake

PROJECT SUMMARY/ABSTRACT Age-related hearing loss (ARHL) is a highly prevalent chronic condition and is associated with poorer psychosocial well-being, communication, and cognitive function. Evidence that hearing aid (HA) use mitigates negative consequences of ARHL is inconclusive because, in part, longitudinal population-based studies of hearing with sufficient follow-up times are rare and few have considered the extent to which earlier intervention with HA improves long-term HA outcomes and reduces the wide-ranging consequences of ARHL. The long- term objective is to reduce impacts of ARHL by maximizing overall HA benefit. The specific objective is to holistically assess benefits of HA use on psychosocial well-being, communication, and cognitive outcomes that capture general and hearing-specific health and determine the extent to which earlier intervention for ARHL is a determinant of HA benefit. To achieve this objective, two specific aims are proposed. Aim 1 will use longitudinal data from the Medical University of South Carolina (MUSC) Longitudinal Cohort Study of ARHL to determine benefits of HA use and assess contributions of early intervention and test hypotheses that a) use of HA will be associated with better general health aspects of psychosocial well-being, cognition, and communication, and b) earlier intervention with HA will be associated with greater HA benefit as determined by these outcomes. Aim 2 will use cross-temporal data to determine benefits of HA use and assess contributions of early intervention using historic and newly collected data from participants in the MUSC Longitudinal Cohort Study of ARHL to test hypotheses that a) use of HA will be associated with better hearing-specific psychosocial well-being and communication outcomes, and b) earlier intervention with HA will be associated with greater HA benefit as determined by these outcomes. Results from this project will positively impact public health research and clinical practice. Specifically, results can inform future epidemiological research and/or clinical trials aiming to determine effects of early intervention on HA benefit, optimal timing of HA interventions, and the appropriate age to begin screening for ARHL. This project and line of research directly addresses the National Academies of Sciences, Engineering, and Medicine (2016) recommendation to improve prospective population-based evidence on impacts of ARHL and its treatment and aligns with NIDCD’s strategic plan on secondary and tertiary prevention and health promotion for individuals with ARHL. That is, this proposal aims to determine importance of early intervention for ARHL (secondary prevention) and benefits of HA use (tertiary prevention) on general and hearing-related measures of psychosocial well-being, communication, and cognition. This project and training plan will provide rigorous mentored training in new methods focused on epidemiological and public health research in audiology, grantsmanship, teaching, and career/professional development, and will support the applicant’s long-term goals of being an independent, NIH-funded clinician-researcher.

项目概要/摘要 年龄相关性听力损失（ARHL）是一种非常普遍的慢性疾病，与较差的听力损失有关。 有证据表明使用助听器 (HA) 会减轻社会心理健康、沟通和认知功能。 ARHL 的负面影响尚无定论，部分原因是基于人群的纵向研究 具有足够后续时间的听证会很少见，很少有人考虑早期干预的程度 HA 可以改善 HA 的长期结果并减少 ARHL 的广泛后果。 长期目标是通过最大化 HA 的整体效益来减少 ARHL 的影响。具体目标是： 全面评估 HA 使用对社会福祉、沟通和认知结果的益处， 捕获一般健康状况和听力特定健康状况，并确定 ARHL 早期干预的程度 为实现这一目标，将提出目标 1 的两个具体目标。 来自南卡罗来纳医科大学 (MUSC) ARHL 纵向队列研究的纵向数据 确定使用 HA 的益处并评估早期干预的贡献并测试以下假设： HA 将与社会心理健康、认知和健康等方面的总体健康状况改善相关。 沟通，以及 b) 尽早对 HA 进行干预将带来更大的 HA 益处，具体如下： 目标 2 将使用跨时间数据来确定 HA 使用的效益并评估贡献。 使用来自 MUSC 纵向队列参与者的历史数据和新收集的数据进行早期干预 ARHL 研究旨在检验以下假设：a) 使用 HA 与更好的听力特定心理社会相关 b) 早期对 HA 的干预将与更好的 HA 相关 这些结果所确定的效益将对公共卫生研究产生积极影响。 具体来说，结果可以为未来的流行病学研究和/或临床试验提供信息。 确定早期干预对 HA 效益的影响、HA 干预的最佳时机以及适当的干预措施 开始筛查 ARHL 的年龄 该项目和研究方向直接针对国家科学院。 科学、工程和医学 (2016) 建议改善基于人群的前瞻性 关于 ARHL 及其治疗影响的证据，并与 NIDCD 的二级和二级治疗战略计划保持一致 ARHL 患者的三级预防和健康促进 即，本提案旨在确定 ARHL 患者的三级预防和健康促进。 ARHL 早期干预的重要性（二级预防）和使用 HA 的益处（三级预防） 关于社会心理健康、沟通和认知的一般和与听力相关的测量。 项目和培训计划将提供以流行病学为重点的新方法的严格指导培训 听力学、资助、教学和职业/专业发展方面的公共卫生研究，以及 将支持申请人成为独立的、由 NIH 资助的临床医生研究员的长期目标。