Multilevel factors influencing racial, ethnic, and socioeconomic disparities in hidradenitis suppurativa

影响化脓性汗腺炎种族、民族和社会经济差异的多层次因素

基本信息

批准号：
10721135
负责人：
Aileen Yenting Chang
金额：
$ 16.73万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10721135
关键词：
Address Adult Affect Age Awareness Biological Biological Response Modifier Therapy Biometry Black race California Caring Cicatrix Clinic Clinical Clinical Investigator Collection Communities County Cyst Data Data Set Data Sources Dermatologist Dermatology Development Development Plans Diagnosis Disease Disease Outcome Disparity Economics Environment Epidemiologic Methods Epidemiology Ethnic Origin Evaluation FDA approved Family Foundations Funding Future Generations Goals Health Health Disparities Research Health Services Accessibility Health behavior Health system Hidradenitis Suppurativa Hispanic Immune Individual Institution Intervention Knowledge Mediating Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Modeling National Institute on Minority Health and Health Disparities Neighborhoods Observational Study Outcome Pain Participant Patient Outcomes Assessments Patient-Focused Outcomes Patients Persons Pharmaceutical Preparations Population Prevalence Process Provider Public Health Public Hospitals Race Recurrence Reporting Research Research Methodology Research Proposals Rural Community Rural Population Sampling San Francisco Severities Severity of illness Shapes Sinus Site Socioeconomic Status Structure Surveys Techniques Time Training United States United States National Institutes of Health Universities Urban Community Work career development chronic inflammatory disease chronic inflammatory skin cohort community-level factor data de-identification data repository design diverse data economic determinant effective intervention ethnic minority ethnic minority population evidence base experience health data health disparity improved improved outcome indexing inhibitor therapy innovation low socioeconomic status minority patient multidisciplinary racial diversity racial minority racial minority population research and development sex skills skin abscess skin disorder social culture social health determinants sociodemographics socioeconomic disparity socioeconomics study population therapy development tumor necrosis factor-alpha inhibitor

项目摘要

PROJECT SUMMARY/ABSTRACT Hidradenitis suppurativa is a chronic inflammatory disease marked by painful, recurrent skin abscesses, cysts, draining sinus tracts, and disfiguring scarring. Hidradenitis suppurativa disproportionately affects racial and ethnic minority groups. Despite an awareness of these disparities, the underlying causes have not been adequately studied. Dr. Chang is seeking an NIH K23 Mentored Patient-Oriented Research Career Development Award to acquire the necessary mentored training, practical experience, and knowledge to become an independently funded clinical investigator of health disparities in chronic inflammatory skin diseases with a focus on hidradenitis suppurativa. Towards this goal, the overall objective of this application is to identify individual-level, interpersonal-level, and community-level factors that influence hidradenitis suppurativa epidemiology and outcomes. Understanding these multilevel factors and their interactions is pivotal for advancing our understanding of hidradenitis suppurativa and designing effective interventions to improve hidradenitis suppurativa management. Dr. Chang proposes to: 1) Use a large racially and socioeconomically diverse dataset to identify differences in hidradenitis suppurativa prevalence based on individual-level and community-level factors and to evaluate the association between individual-level and community-level factors and receiving biologic therapy for hidradenitis suppurativa; 2) Assess individual-, interpersonal-, and community-level factors associated with time to diagnosis by conducting a survey study of racially and socioeconomically diverse adults living with hidradenitis suppurativa; 3) Identify patient-reported facilitators of obtaining care for hidradenitis suppurativa using a mixed methods approach with racially and socioeconomically diverse study participants. A mentoring team with multidisciplinary expertise will guide Dr. Chang's career development and research progress: immune-mediated diseases (Dr. Yazdany), hidradenitis suppurativa (Drs. Naik and Linos), epidemiologic methods for observational studies (Drs. Yazdany and Linos), health disparities research (Drs. Yazdany and Ackerman), qualitative/mixed methods research (Drs. Ackerman and Linos). Their mentorship combined with focused training and the proposed research plan will develop Dr. Chang's expertise in health disparities research in chronic inflammatory diseases.

项目概要/摘要化脓性汗腺炎是一种慢性炎症性疾病，以疼痛、复发性皮肤脓肿、囊肿、引流窦道，并造成毁容疤痕。化脓性汗腺炎对种族和种族的影响不成比例。少数民族群体。尽管人们意识到了这些差异，但根本原因尚未得到解决充分研究。张博士正在寻求 NIH K23 指导的以患者为导向的研究职业发展奖以获得必要的指导培训、实践经验和知识成为一名独立资助的慢性炎症皮肤健康差异的临床研究者重点关注化脓性汗腺炎的疾病。为了实现这一目标，本应用程序的总体目标是确定影响汗腺炎的个人层面、人际层面和社区层面的因素化脓性流行病学和结果。了解这些多层次因素及其相互作用是对于增进我们对化脓性汗腺炎的了解和设计有效的干预措施至关重要改善化脓性汗腺炎的治疗。张博士建议：1）使用大量的种族和社会经济多样化的数据集，用于根据以下因素确定化脓性汗腺炎患病率的差异个人层面和社区层面的因素，并评估个人层面和社区层面的因素之间的关联社区因素和接受化脓性汗腺炎生物治疗； 2) 评估个人-, 通过进行一项调查研究，了解与诊断时间相关的人际和社区层面的因素患有化脓性汗腺炎的种族和社会经济多样化的成年人； 3) 识别患者报告的使用种族和种族混合方法获得化脓性汗腺炎护理的促进者社会经济多样化的研究参与者。具有多学科专业知识的指导团队将指导博士。 Chang的职业发展和研究进展：免疫介导疾病（Dr. Yazdany）、汗腺炎化脓性（Naik 博士和 Linos 博士）、观察性研究的流行病学方法（Yazdany 博士和 Linos 博士）、健康差异研究（Yazdany 博士和 Ackerman 博士）、定性/混合方法研究（Ackerman 博士和利诺斯）。他们的指导加上重点培训和拟议的研究计划将培养博士。张在慢性炎症性疾病健康差异研究方面拥有专业知识。