The Feasibility and Acceptability of Resistance Training and Creatine Supplementation to Promote Physical Function in Sarcopenic Colorectal Cancer Survivors

抵抗训练和补充肌酸促进肌少症结直肠癌幸存者身体机能的可行性和可接受性

• 批准号: 10712237
• 负责人: Ciaran Fairman
• 金额: $ 20.27万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712237
• 关键词: Acceleration; Address; Adherence; Adverse event; Affect; Aftercare; Aging; Biology; Body Composition; Body fat; Bone Mineral Contents; Cancer Survivor; Characteristics; Clinical; Colorectal Cancer; Creatine; Data; Diagnosis; Dietary Intervention; Economic Burden; Effectiveness; Elderly; Etiology; Exercise; Future; Goals; Health; Healthcare Systems; Hospital Costs; Individual; Inflammation; Intervention; Investigation; Malignant Neoplasms; Malnutrition; Measures; Mitochondria; Molecular; Morbidity - disease rate; Muscle; Muscle Cells; Muscle function; Natural Compound; Nutritional Study; Outcome; Outcome Measure; Physical Function; Placebos; Play; Population; Prognosis; Quality of life; Randomized; Randomized, Controlled Trials; Recommendation; Reporting; Research Priority; Role; Safety; Sampling; Signal Transduction; Supplementation; Testing; Therapeutic; Thinness; Treatment-related toxicity; Tumor Burden; Woman; acceptability and feasibility; arm; cancer care; cancer diagnosis; cancer therapy; chemotherapy; colon cancer patients; colorectal cancer treatment; cost estimate; density; design; dietary supplements; disability; exercise intervention; exercise training; experience; health related quality of life; innovation; insight; intervention effect; lifestyle intervention; men; mitochondrial dysfunction; mortality; multimodality; muscle form; muscle strength; novel; physical inactivity; pilot trial; prognostic; protein degradation; recruit; reduced muscle mass; resistance exercise; response; sarcopenia; secondary outcome; side effect; skeletal muscle wasting; success; trial comparing

Colorectal cancer is the third most commonly diagnosed cancer in the world. Sarcopenia, defined as a loss of skeletal muscle mass and function, is highly prevalent in colorectal cancer, with rates of up to 60% reported. Sarcopenia etiology in cancer is multifactorial, with aging and inactivity compounded by treatment toxicities, malnutrition, tumor burden, and high-grade inflammation. Consequently, it’s unlikely that unimodal interventions will be sufficient to overcome the burden of sarcopenia in this population. Creatine monohydrate is a naturally occurring compound in the body that plays a critical role in energy provision during exercise.4 Creatine is the most widely studied nutritional supplement to date, with well over 1,000 studies establishing its safety and effectiveness in men, women and older adults, in addition to other clinical populations. There is strong and consistent evidence that creatine supplementation can enhance the positive adaptations to resistance training in older adults and clinical populations. Therefore, there is strong potential for the application of creatine and resistance training to offset the decline in muscle mass and function after cancer treatment. The purpose of the proposed study is to examine the feasibility and acceptability of creatine supplementation combined with resistance exercise, compared to resistance exercise alone in individuals treated for colorectal cancer who are sarcopenic. We propose a randomized controlled pilot trial, examining the effects of 10-week multimodal resistance exercise and creatine supplementation (EXSUPP) (n=20) relative to resistance exercise alone (EXPLA) (n=20) in individuals treated for colorectal cancer who have sarcopenia. The specific aims of this project are to 1) determine the feasibility and acceptability of the intervention in colorectal cancer patients? diagnosed with sarcopenia after cancer treatment, 2) compare the effects of an exercise and creatine supplementation intervention (EXSUPP) to exercise alone (EXPLA) on body composition, muscle strength, physical function, and quality of life and 3) explore muscle molecular-level adaptations, i.e., mitochondrial health and protein turnover, in response to the interventions. This project will be one of the first to combine exercise with creatine, specifically targeting sarcopenia in individuals previously treated for colorectal cancer. This project is directly in line with the priority research initiative from the NCI Cancer MoonshotSM to “minimize Cancer Treatment’s Debilitating Side Effects.” Our trial is innovative in addressing one of the most important health problems for individuals treated for colorectal cancer in that it will be the first to 1) examine the feasibility and acceptability of a multimodal exercise and nutritional intervention relative to exercise alone in individuals treated for colorectal cancer who are sarcopenic and 2) explore the molecular mechanisms underpinning the response to exercise and nutritional interventions.

结直肠癌是世界上第三大最常见的癌症，被定义为肌肉减少症。 骨骼肌质量和功能在结直肠癌中非常常见，据报道发病率高达 60%。 癌症中的肌肉减少症病因是多因素的，衰老和不活动加上毒性治疗， 经过测试，营养不良、肿瘤负担和高级炎症不太可能是单峰的。 干预措施足以克服该人群的肌少症负担。 是体内天然存在的化合物，在运动期间的能量供应中发挥着关键作用。4 肌酸是迄今为止研究最广泛的营养补充剂，有超过 1,000 项研究证实其 除其他临床人群外，其对男性、女性和老年人的安全性和有效性。 强有力且一致的证据表明，补充肌酸可以增强积极的适应能力 因此，老年人和临床人群的阻力训练具有巨大的潜力。 应用肌酸和阻力训练来抵消癌症后肌肉质量和功能的下降 拟议研究的目的是检查肌酸治疗的可行性和可接受性。 结合抗阻运动，与个人单独进行抗阻运动相比 我们建议进行一项随机对照试点试验，检查肌肉减少症的结直肠癌患者。 10 周多模式抗阻运动和肌酸补充 (EXSUPP) (n=20) 相对于 在接受结直肠癌治疗且患有肌肉减少症的个体中单独进行抗阻运动 (EXPLA) (n=20)。 该项目的具体目标是 1) 确定干预措施的可行性和可接受性 结直肠癌患者在癌症治疗后诊断出肌肉减少症，2）比较 运动和肌酸补充干预（EXSUPP）到单独运动（EXPLA）对身体的影响 成分、肌肉力量、身体功能和生活质量，3) 探索肌肉分子水平 该项目将针对干预措施进行适应性调整，即线粒体健康和蛋白质周转。 最早将运动与肌酸结合起来的公司之一，专门针对以前个体的肌少症 该项目直接符合 NCI 的优先研究计划。 Cancer MoonshotSM 旨在“最大限度地减少癌症治疗的令人衰弱的副作用”。 解决结直肠癌治疗者最重要的健康问题之一，因为它将 成为第一个 1) 检查多模式运动和营养干预的可行性和可接受性的人 相对于接受肌肉减少症的结直肠癌治疗个体的单独锻炼而言，2) 探索 支持运动和营养干预反应的分子机制。