IUB C3A Pilot Project Core

IUB C3A 试点项目核心

基本信息

批准号：
10713093
负责人：
Norbert Hajos
金额：
$ 15.79万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10713093
关键词：
Address Adolescent African-American Graduate Student Anatomy Applications Grants Area Cannabinoids Cannabis Career Choice Clinical Data Drug Addiction Drug abuse Drug usage Education Educational Status Ensure Equity Experimental Designs Feedback Funding Gills Goals Grant Human Image Indiana Individual Inhalation Kentucky Knowledge Lipids Location Mentors Methodology Modeling Molecular National Institute of Drug Abuse Nature Neurosciences Opioid Outcome Pilot Projects Plasma Population Postdoctoral Fellow Process Publications Rattus Research Research Personnel Resources Scientist Societies Substance abuse problem Summary Reports Support Groups System THC exposure Talents Techniques Traumatic Brain Injury Universities Work Writing addiction career cognitive change design experimental study graduate student high risk innovation insight interest lipidome lipidomics meetings member mild traumatic brain injury multiple drug use novel opioid user phytocannabinoid process improvement professor programs recruit skills success

项目摘要

Pilot Project Core Abstract The IUB Center for Cannabis, Cannabinoids and Addiction (C3A) Pilot Project Core will establish a pilot project program designed to support 2 to 4 new projects/year. The Pilot Project Core PI is Professor Norbert Hájos, who holds a Gill Chair of Neuroscience. Its goal is to support and encourage innovative and exploratory projects from trainees and establish investigators exploring new lines of research related to substance abuse. Pilot projects will be solicited annually from C3A Affiliates and their trainees. We anticipate that some of these pilot project proposals will come from trainees supported by our NIDA-T32, DA024628. Each proposal will be reviewed by 2 members of the External Advisory Board and 2 members of the Internal Advisory Board. Proposals will be ranked by the following priorities: 1. Support of young investigators/investigators new to the addiction field. 2. Support of groups historically underrepresented in drug abuse research. 3. A project that will maximally benefit from access to either the BLM or MSPM cores. 4. Obtain preliminary data for NIDA grant application. 5. Includes a component of high risk/high payout. Low priority will be given to proposals that merely supplement ongoing funded research. All applicants will receive feedback on their proposals and will be offered the opportunity to be mentored by a C3A PI or Affiliate in subsequent applications to the C3A or external agencies. Successful applicants will be assigned a Core staff member to optimize experimental design with the technical capabilities of the relevant core(s) utilized and matched with a IUB C3A Center Affiliate to provide guidance in the substance abuse field. Awardees will present their work at least three times to the monthly C3A research meetings and once to the external advisory board. A summary report will also be prepared when the project is completed. Based on these criteria, we have chosen two projects for the initial submission of this P30. Pilot Project 1 has been proposed by Gabriel Nah, a graduate student working with Dr. Jonathan Crystal, a Provost Professor at IU Bloomington. Mr. Nah’s project uses a rat model to examine the impact of adolescent THC exposure on the lipidomic, anatomical, molecular, and cognitive changes following mild traumatic brain injury and will use both the lipidomics and imaging cores. Pilot Project 2 has been proposed by Center Affiliate, Dr. Shanna Babalonis, as assistant professor at the University of Kentucky studying multi-drug use in human populations. Dr. Babalonis’ project will use the lipidomics core to examine the plasma lipidome and phytocannabinoid levels in opioid users in a controlled setting with and without inhaled cannabis exposure. These two pilot projects meet the goals of the Pilot Project Core in the following ways: Project 1 supports an African American graduate student working on a significant question addressing the impact of prior drug use on the sequelae of traumatic brain injury. Project 2 supports an early-stage investigator examining the interactions between cannabinoids, lipids, and opioids in a clinical population.

试点项目核心摘要 IUB 大麻、大麻素和成瘾中心 (C3A) 试点项目核心将建立一个试点项目该试点项目的核心 PI 是 Norbert Hájos 教授，旨在支持每年 2 至 4 个新项目。担任吉尔神经科学主席。其目标是支持和鼓励创新和探索性。受训者的项目，并建立调查人员探索与药物滥用相关的新研究领域。我们预计将每年向 C3A 附属机构及其学员征集试点项目。试点项目提案将来自我们的 NIDA-T32、DA024628 支持的学员。由 2 名外部顾问委员会成员和 2 名内部顾问委员会成员审核。提案将按以下优先顺序进行排序： 1. 支持年轻研究者/刚接触该领域的研究者 2. 对历史上在药物滥用研究中代表性不足的群体的支持 3. 一个项目。将最大程度地受益于 BLM 或 MSPM 核心 4. 获取 NIDA 拨款的初步数据。 5. 包含高风险/高回报的部分，将给予低优先级的提案。只是补充正在进行的资助研究。所有申请人都将收到有关其提案的反馈，并将被采纳。在后续的 C3A 申请中提供获得 C3A PI 或附属机构指导的机会成功的申请者将被指派一名核心工作人员来优化实验。设计采用相关核心的技术能力并与 IUB C3A 中心相匹配在药物滥用领域提供指导的附属机构将至少展示三次他们的作品。每月一次的 C3A 研究会议和一次外部顾问委员会还将收到一份总结报告。项目完成时准备。根据这些标准，我们选择了两个项目作为 P30 试点项目 1 的初始提交。是由研究生加布里埃尔·纳 (Gabriel Nah) 与教务长教授乔纳森·克里斯托 (Jonathan Crystal) 博士合作提出的。 IU 布卢明顿 (IU Bloomington) 先生的项目使用大鼠模型来研究青少年接触 THC 的影响。轻度创伤性脑损伤后的脂质组学、解剖学、分子和认知变化，并将使用两者试点项目 2 是由中心附属机构 Shanna Babalonis 博士提出的。作为肯塔基大学的助理教授，研究人群中的多种药物使用。 Babalonis 的项目将使用脂质组学核心来检查血浆脂质组和植物大麻素水平在受控环境下吸食和不吸食大麻的阿片类药物使用者这两个试点项目相吻合。通过以下方式实现试点项目核心的目标：项目 1 支持非裔美国毕业生学生正在研究一个重要问题，该问题涉及先前吸毒对创伤后遗症的影响项目 2 支持早期研究人员检查大麻素之间的相互作用，临床人群中的脂质和阿片类药物。