IUB C3A Pilot Project Core

IUB C3A 试点项目核心

• 批准号: 10713093
• 负责人: Norbert Hajos
• 金额: $ 15.79万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713093
• 关键词: Address; Adolescent; African-American Graduate Student; Anatomy; Applications Grants; Area; Cannabinoids; Cannabis; Career Choice; Clinical; Data; Drug Addiction; Drug abuse; Drug usage; Education; Educational Status; Ensure; Equity; Experimental Designs; Feedback; Funding; Gills; Goals; Grant; Human; Image; Indiana; Individual; Inhalation; Kentucky; Knowledge; Lipids; Location; Mentors; Methodology; Modeling; Molecular; National Institute of Drug Abuse; Nature; Neurosciences; Opioid; Outcome; Pilot Projects; Plasma; Population; Postdoctoral Fellow; Process; Publications; Rattus; Research; Research Personnel; Resources; Scientist; Societies; Substance abuse problem; Summary Reports; Support Groups; System; THC exposure; Talents; Techniques; Traumatic Brain Injury; Universities; Work; Writing; addiction; career; cognitive change; design; experimental study; graduate student; high risk; innovation; insight; interest; lipidome; lipidomics; meetings; member; mild traumatic brain injury; multiple drug use; novel; opioid user; phytocannabinoid; process improvement; professor; programs; recruit; skills; success

Pilot Project Core Abstract The IUB Center for Cannabis, Cannabinoids and Addiction (C3A) Pilot Project Core will establish a pilot project program designed to support 2 to 4 new projects/year. The Pilot Project Core PI is Professor Norbert Hájos, who holds a Gill Chair of Neuroscience. Its goal is to support and encourage innovative and exploratory projects from trainees and establish investigators exploring new lines of research related to substance abuse. Pilot projects will be solicited annually from C3A Affiliates and their trainees. We anticipate that some of these pilot project proposals will come from trainees supported by our NIDA-T32, DA024628. Each proposal will be reviewed by 2 members of the External Advisory Board and 2 members of the Internal Advisory Board. Proposals will be ranked by the following priorities: 1. Support of young investigators/investigators new to the addiction field. 2. Support of groups historically underrepresented in drug abuse research. 3. A project that will maximally benefit from access to either the BLM or MSPM cores. 4. Obtain preliminary data for NIDA grant application. 5. Includes a component of high risk/high payout. Low priority will be given to proposals that merely supplement ongoing funded research. All applicants will receive feedback on their proposals and will be offered the opportunity to be mentored by a C3A PI or Affiliate in subsequent applications to the C3A or external agencies. Successful applicants will be assigned a Core staff member to optimize experimental design with the technical capabilities of the relevant core(s) utilized and matched with a IUB C3A Center Affiliate to provide guidance in the substance abuse field. Awardees will present their work at least three times to the monthly C3A research meetings and once to the external advisory board. A summary report will also be prepared when the project is completed. Based on these criteria, we have chosen two projects for the initial submission of this P30. Pilot Project 1 has been proposed by Gabriel Nah, a graduate student working with Dr. Jonathan Crystal, a Provost Professor at IU Bloomington. Mr. Nah’s project uses a rat model to examine the impact of adolescent THC exposure on the lipidomic, anatomical, molecular, and cognitive changes following mild traumatic brain injury and will use both the lipidomics and imaging cores. Pilot Project 2 has been proposed by Center Affiliate, Dr. Shanna Babalonis, as assistant professor at the University of Kentucky studying multi-drug use in human populations. Dr. Babalonis’ project will use the lipidomics core to examine the plasma lipidome and phytocannabinoid levels in opioid users in a controlled setting with and without inhaled cannabis exposure. These two pilot projects meet the goals of the Pilot Project Core in the following ways: Project 1 supports an African American graduate student working on a significant question addressing the impact of prior drug use on the sequelae of traumatic brain injury. Project 2 supports an early-stage investigator examining the interactions between cannabinoids, lipids, and opioids in a clinical population.

试点项目核心摘要 IUB大麻，大麻素和成瘾中心（C3A）试点项目核心将建立一个试点项目 计划旨在支持2至4个新项目/年。飞行员项目核心PI是NorbertHájos教授， 拥有神经科学的吉尔主席。它的目标是支持和鼓励创新和探索性 来自学员的项目并成立研究人员，探索与滥用药物有关的新研究线。 试点项目将每年从C3A分支机构及其学员那里征求。我们预计其中一些 试点项目建议将来自我们的NIDA-T32 DA024628支持的受训者。每个建议将是 由外部顾问委员会的2名成员和内部咨询委员会的2名成员进行审查。 提案将按以下优先事项进行排名：1。 成瘾字段。 2。在历史上支持药物滥用研究的人数不足。 3。一个项目 将从访问BLM或MSPM内核中最大受益。 4。获取NIDA赠款的初步数据 应用。 5。包括高风险/高薪的组成部分。优先级将是对提案的优先事项 仅补充正在进行的资助研究。所有申请人都会收到有关其建议的反馈，将是 在随后的C3A申请或 外部机构。成功的申请人将被分配为核心工作人员，以优化实验 具有使用并与IUB C3A中心相匹配的相关核心的技术功能的设计 分支机构在药物滥用领域提供指导。获奖者将至少介绍他们的作品三次 参加每月的C3A研究会议，然后到外部顾问委员会。摘要报告也将是 项目完成后准备。 根据这些标准，我们选择了两个项目以初次提交此P30。飞行员项目1有 他是由与乔纳森·克里斯特尔（Jonathan Crystal）博士一起的研究生Gabriel Nah提出的， IU Bloomington。 NAH先生的项目使用大鼠模型来检查青少年THC暴露对 轻度创伤性脑损伤后，脂质组，解剖学，分子和认知变化，并将同时使用 脂质组学和成像核心。飞行员项目2由中心会员Shanna Babalonis博士提出 作为肯塔基大学的助理教授，研究人口中的多药用使用。博士 Babalonis的项目将使用脂质核学核心来检查血浆脂肪组和植物大麻素水平 在有或没有遗传大麻曝光的受控设置中，opioid用户。这两个飞行员项目见面 飞行员项目核心的目标以以下方式：项目1支持非裔美国人的毕业生 研究了一个重大问题的学生，以解决先前使用药物对创伤后遗症的影响 脑损伤。项目2支持一个早期研究者，研究大麻素之间的相互作用， 脂质和临床人群中的阿片类药物。