Integrative Systems Biology Core

PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. We will ensure that the experimental data is analyzed appropriately to test the hypotheses relevant to each project. In addition, the Integrative Systems Biology Core will provide infrastructure and oversight for secure management of all study data, working closely with the Bioreagents & Resource Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To integrate cutting-edge analytic approaches in the design, analysis, and interpretation of experimental studies across projects in our program; and (2) To provide secure and accessible database systems and computational infrastructure to facilitate reliable and reproducible analyses conducted by all program investigators. The Integrative Systems Biology Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine and the Duke Molecular Physiology Institute. Dr. Thomas LaFramboise will direct the Core, with Dr. Simon Gregory as co-director. The Integrative Systems Biology Core will serve as a centralized resource for all personnel, including the leaders of the three research projects and the Bioreagents & Resource Core. The Core will assist investigators with all facets of design, computational analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for investigators within the Core. Core personnel will interact with investigators in all stages of research, from data management, data analysis, interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems, facilitating analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Bioreagents & Resource Core. The Integrative Systems Biology Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.

项目摘要/摘要 集成系统生物学核心将与所有研究人员进行互动，以开发和应用适当的分析 最有效地实现项目目标的方法和设计。我们将确保实验数据是 进行了适当的分析以测试与每个项目相关的假设。此外，集成系统 生物学核心将提供基础架构和监督，以确保所有研究数据的安全管理 具有生物因素和资源核心，以促进所有项目的数据集准确性和完整性 调查人员。我们的具体目的是：（1）在设计，分析中整合尖端的分析方法， 以及我们计划中跨项目的实验研究的解释； （2）提供安全和 可访问的数据库系统和计算基础架构，以促进可靠和可重复的分析 由所有计划调查员进行。综合系统生物学核心利用教师和资源 在案例综合癌症中心，西部储备大学医学院和 杜克分子生理研究所。 Thomas Laframboise博士将与Simon Gregory博士指导核心 作为联合导演。综合系统生物学核心将成为所有人员的集中资源， 包括三个研究项目的领导者以及生物因素和资源核心。核心将有助于 设计，计算分析和解释方面的各个方面。建立和小说 可以使用量身定制的分析方法来促进核心内研究人员的科学发现。核 人员将在研究的各个阶段，数据管理，数据分析， 解释，撰写科学手稿和赠款，以传播结果。核心也将 促进访问安全可访问的数据库系统，促进分析，发现和 合作。核心将帮助所有调查人员的项目开发，管理和可靠性 数据并将整合跨数据库的信息，例如合并临床和实验数据 使用生物新闻和资源核心提供的生物循环数据。集成系统生物学核心 将为项目和核心（核心人员）之间的交叉授粉提供自然基础 与所有项目调查员和核心主管合作。