Advanced Gene Mapping Course

高级基因作图课程

• 批准号: 7589651
• 负责人: SUZANNE M LEAL
• 金额: $ 7.29万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-03 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7589651
• 关键词: Categories; Chromosome Mapping; Complex; Computers; Continuing Education; Data; Data Analyses; Databases; Disease; Etiology; Exercise; Extended Family; Family; Genes; Genetic; Genetic Epistasis; Genotype; Goals; Grant; Hand; Haplotypes; Human; Internet; Knowledge; Lead; Link; Linkage Disequilibrium; Linux; Maps; Methods; Microcomputers; Names; Neurofibromin 2; New York; Participant; Postdoctoral Fellow; Research Personnel; Running; Sample Size; Students; Techniques; Training; Travel; Universities; base; case control; computer program; cost; genetic analysis; genetic linkage analysis; genetic pedigree; lectures; population based; pre-doctoral; programs; reconstruction; simulation; skills; tool; trait

DESCRIPTION (provided by applicant): The long-term goal is to provide training in linkage and association analysis thus advancing the understanding of statistical concepts underlying gene mapping methods. Additional goals are to familiarize researchers with the technical tools (application of computer programs) for statistical genetics. It is expected that such training will lead to an improvement in the analysis of genetic data, helping researchers develop the necessary skills to localize and isolate genes for complex traits thus increasing knowledge of disease etiology. The specific aim is to carry out each year one full-week course in advanced gene mapping at The Rockefeller University in New York. The course will be directed towards advanced researchers who are familiar with the basic aspects of statistical genetics but who need to become more proficient in the application of statistical analysis of complex traits. The course will be held in Weiss Hall at The Rockefeller University which is equipped with 24 PCs which are running under Red Hat Linux and are connected to the internet. Twenty-two participants will be admitted to the course. Travel stipends will be provided to seven of the participants who are either pre-doctoral students or post-doctoral fellows to cover the cost of airfare, hotel and board. The course consists of two components: lectures on important and current topics in gene mapping, as well as hands on exercises to be carried out with computer programs. Topics to be covered include: nonparametric linkage analysis in sib-pairs and extended families for quantitative and qualitative traits; variance components analysis; linkage disequilibrium; haplotype reconstruction; gene x gene interaction; tag SNP selection; association analysis (for case-control, quantitative and family based data); data cleaning; power analysis; empirical p-values; and the false discover rate.

描述（由申请人提供）：长期目标是提供链接和关联分析中的培训，从而促进对基因映射方法基础统计概念的理解。其他目标是使研究人员熟悉用于统计遗传学的技术工具（计算机程序的应用）。预计这种训练将导致对遗传数据的分析有所改善，从而帮助研究人员发展必要的技能，以将基因定位和分离为复杂性状，从而提高对疾病病因的了解。 具体的目的是每年在纽约洛克菲勒大学的高级基因映射中进行一整周的课程。该课程将针对熟悉统计遗传学的基本方面但需要更精确地应用复杂性状统计分析的高级研究人员。该课程将在洛克菲勒大学的魏斯音乐厅举行，该大学配备了24个PC，这些PC在Red Hat Linux下运行，并连接到Internet。 22名参与者将被录取。将向七名参与者提供旅行津贴，他们是博士后学生或博士后研究员，以支付机票，酒店和董事会的费用。 该课程由两个组成部分组成：关于基因映射的重要和当前主题的讲座，以及计算机程序进行的练习。要涵盖的主题包括：以SIB对的非参数链接分析，以及用于定量和定性性状的大家庭；方差组件分析；连锁不平衡；单倍型重建；基因X基因相互作用；标签SNP选择；关联分析（用于病例对照，定量和基于家庭的数据）；数据清洁；功率分析；经验P值；和错误的发现率。