Molecular Analysis of Microbial Pathogens

微生物病原体的分子分析

• 批准号: 7649474
• 负责人: Ralph R. Isberg
• 金额: $ 18万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649474
• 关键词: Molecular Analysis; microbial; pathogen; Molecular Analysis; microbial; pathogen

DESCRIPTION (provided by applicant): This application requests support for continuation of a rigorous predoctoral training Program that focuses on the molecular analysis of microbial pathogens. The Program is interdepartmental and is centered around the Department of Molecular Biology and Microbiology, with members being drawn from the Departments of Biochemistry, Medicine, Infectious Diseases, and Pathology. All investigators have either a common interest in pathogenic microorganisms, restriction of pathogens in cell or animal models, in basic processes performed by such microorganisms, or have complementary expertise in molecular biology. The varied research interests of the group include: a) bacterial pathogenesis, including the study of colonization, intracellular growth, toxin expression and development of tools to study microbial genes expressed during animal infections; b) viral pathogenesis and replication; c) sporulation as model regulatory and pathogenic system; d) protein secretion and the analysis of microbial surfaces, including those of pathogenic bacteria and yeast; and e) regulation of gene expression and cell growth in microbial model systems; f) analysis of developmental stages in fungal pathogens; g) mouse models of innate immunity. The members of this Program use genetic and biochemical strategies to analyze microbial pathogens, as well as animal infection models. This Program has a long history of having a strong collaborative spirit of learning and research among faculty and students. Recruitment and admission strategies have been highly successful, with an excellent minority recruitment program, with 20% of the students being members of underrepresented minority groups, as defined by NIH guidelines. The overwhelming majority of the 140 Ph.D. graduates of the Department since 1964 are currently employed in research positions in academics and industry, with approximately 50% of the graduates who have finished postdoctoral training currently holding faculty positions The Program is overseen by the Training Committee, a group of internationally recognized bacteriologists and virologists who participate in the graduate education of all trainees. All faculty members of the Program have individual NIH grants or other forms of support. The application is for 5 years, with 5 predoctoral trainees requested for each of years 01 -05.

描述（由申请人提供）：本申请要求支持继续进行严格的术前训练计划，该计划的重点是微生物病原体的分子分析。该计划是部门间的，以分子生物学和微生物学系为中心，成员来自生物化学，医学，传染病和病理学部门。所有研究者在病原微生物，细胞或动物模型中对病原体的限制，在这种微生物进行的基本过程中都具有共同的兴趣，或者在分子生物学方面具有互补的专业知识。该组的各种研究兴趣包括：a）细菌发病机理，包括对定植，细胞内生长，毒素表达和开发研究在动物感染过程中表达的微生物基因的工具的开发； b）病毒发病机理和复制； c）作为模型调节和致病系统的孢子形成； d）蛋白质分泌和微生物表面的分析，包括致病性细菌和酵母菌的表面； E）调节微生物模型系统中基因表达和细胞生长； f）分析真菌病原体的发育阶段； g）先天免疫的小鼠模型。该计划的成员使用遗传和生化策略来分析微生物病原体以及动物感染模型。该计划有悠久的历史，即在教师和学生之间拥有强烈的学习和研究精神。招聘和入学策略取得了非常成功的少数族裔招聘计划，其中20％的学生是NIH指南所定义的代表性不足的少数群体成员。 140 Ph.D.中的绝大多数自1964年以来，该系的毕业生目前从事学术界和行业的研究职位，大约有50％的毕业生完成了博士后培训，目前担任教职员工的职位，该计划受到培训委员会的监督，该计划是一组国际认可的细菌学家和参与所有受训者的研究生教育的人。该计划的所有教职员工都有个人NIH赠款或其他形式的支持。该申请持续了5年，每年为01 -05年要求5名托管学员。