Fellowship Training Program in Vaccinology

疫苗学奖学金培训计划

• 批准号: 7658831
• 负责人: Myron Max Levine
• 金额: $ 25.21万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7658831
• 关键词: Fellowship; Training Programs; vaccinology

DESCRIPTION (provided by applicant): Vaccination represents one of the most cost effective approaches in preventive medicine. Over the past two decades, new techniques in recombinant DMA and biotechnology offer unprecedented opportunities for the development of new vaccines. Many training opportunities exist to prepare individuals for research in immunology, molecular genetics, infectious diseases, and other specific aspects of vaccine development, but too few training opportunities offer broad exposure to both laboratory and clinical trial aspects of vaccinology. For the past 32 years, the Center for Vaccine Development of the University of Maryland School of Medicine has been involved in all aspects of vaccine development, from basic laboratory studies involving genetic construction of recombinant vaccines to Phase 1 through Phase 4 clinical trials. We propose to continue a formal training program in which individuals with M.D. or Ph.D. degrees can be prepared specifically for careers in vaccinology, either to pursue basic vaccine development research or to conduct investigative clinical trials. The number of trainees involved in this training program will be two per year for a total of five years. Support only for years 1 and 2 are requested from this proposal; support for the third and possible fourth years will be generated from fellowships, research grants, or other sources. The training program in Vaccinology offers to all trainees a broad exposure to both the laboratory and clinical trial phases of vaccinology. Beyond this broad exposure, the program is set up as two tracks so that each trainee will gain more intensive experience in either the laboratory aspects or the clinical phases of vaccinology, depending upon which track they choose. The Laboratory track will allow the training of basic scientists and physician/scientists in vaccine development laboratory research, particularly in the use of recombinant DNA technology to prepare new vaccine candidates and the use of modern immunological techniques to study the human humoral and cellular immune response to different vaccines. The Clinical track will train clinicians (internists or pediatricians) in clinical trial design, protocol preparation, procurement of administrative and ethical clearances, performance of clinical trials and analysis of data. The ultimate goal of this training program is to provide a well-trained cadre of individuals who can fully exploit the unprecedented opportunities now available in vaccine development.

描述（由申请人提供）：疫苗接种是预防医学中最具成本效益的方法之一。在过去的二十年中，重组DMA和生物技术领域的新技术为开发新疫苗提供了前所未有的机会。存在许多培训机会，可以使个人为免疫学，分子遗传学，传染病以及疫苗开发的其他特定方面的研究做好准备，但是培训机会太少，可以为实验室和临床试验方面的疫苗科学方面提供广泛的暴露。在过去的32年中，马里兰大学医学院的疫苗开发中心参与了疫苗开发的各个方面，从涉及重组疫苗的基因结构到第1阶段到第4阶段临床试验的基础实验室研究。我们建议继续一项正式培训计划，其中拥有医学博士学位或博士学位的个人。学位可以专门针对疫苗学的职业，要么从事基本疫苗开发研究或进行调查性临床试验。参与该培训计划的学员人数将为每年两年，总计五年。该提案仅要求提供1年和第2年的支持；第三年也是第四年的支持将从研究金，研究补助金或其他来源产生。疫苗学方面的培训计划为所有学员提供了对疫苗学的实验室和临床试验阶段的广泛接触。除了这一广泛的曝光外，该计划还设置为两个轨道，以便每个学员将在实验室方面或疫苗学的临床阶段获得更丰富的经验，具体取决于他们选择的轨道。该实验室的轨道将允许在疫苗开发实验室研究中培训基础科学家和医师/科学家，特别是在使用重组DNA技术来准备新的疫苗候选物以及使用现代免疫技术来研究人类的体液和细胞对不同疫苗的生成反应。临床轨道将培训临床医生（内科医生或儿科医生）进行临床试验设计，协议准备，行政和道德清除的采购，临床试验的表现以及数据分析。该培训计划的最终目标是提供训练有素的人群，这些人能够充分利用疫苗开发中目前可用的前所未有的机会。