Neuroscience of Aging

衰老神经科学

• 批准号: 7611999
• 负责人: JERI JANOWSKY
• 金额: $ 21.54万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7611999
• 关键词: Aging; Neurosciences

DESCRIPTION (provided by applicant): The goals of this pre- and post-doctoral training program are to create scientists with a broad understanding of the neuroscience of aging, including an understanding of the clinical manifestations and basic neuroscience of so-called "normal aging," as well as age-related neuropathologies. This will be accomplished by providing instruction in molecular, cellular, systems, and behavioral approaches to research on the age-related changes of the nervous system, as well as experience with the clinical manifestations of aging and age-related nurodegenerative diseases. The training will be accomplished through course work, seminars, and specialized laboratory and clinical research rotations. Faculty will come from across the OHSU campus, and will train pre-doctoral students through the Neuroscience and Behavioral Neuroscience programs. Most faculty have research collaborations across the following areas of aging research: Aging and Dementia, Cardiovascular Risk and Stroke, Cognition, Aging and Movement Disorders, Sensory Function in Aging, and Neuroendocrinology. The expectation is that this training program will permit the trainees to go on as neuroscientists of aging but with an understanding of how their basic science work is applicable to clinical cures for aging and age-related disorders. Similarly we expect that the clinical research trainees will be able to inform basic scientists on the directions whereby mechanistic work will prove fruitful for clinical application. We request funding for 8 pre-doctoral and 8 post-doctoral trainees over the course of this training grant, to be supported for 2-3 years of training. Pre-doctoral students will enter the program in their second year of graduate school when they have committed to a mentor's lab, and to research on the neuroscience of aging. There are currently no other mechanisms to fund trainees who seek to concentrate on the neuroscience of aging.

描述（由申请人提供）：该博士前和博士后培训计划的目标是创建科学家，对衰老的神经科学有广泛的了解，包括了解所谓的“正常衰老”的临床表现和基本神经科学，以及与年龄相关的神经病理学。这将通过提供分子，细胞，系统和行为方法的指导来研究神经系统与年龄相关的变化，以及具有衰老和与年龄相关的肉虫疾病的临床表现的经验。该培训将通过课程工作，研讨会以及专门的实验室和临床研究旋转来完成。教师将来自OHSU校园，并将通过神经科学和行为神经科学计划培训博士前的学生。大多数教师在衰老研究的以下领域进行了研究合作：衰老和痴呆，心血管风险和中风，认知，衰老和运动障碍，衰老中的感觉功能以及神经内分泌学。期望该培训计划将使受训者成为衰老的神经科学家，但要了解他们的基础科学工作如何适用于临床治疗衰老和与年龄有关的疾病。同样，我们预计临床研究受训者将能够在机械工作中向基础科学家通报基础科学家，从而证明临床应用有效。我们要求在这项培训补助金的培训赠款期间为8个博士后和8名博士后学员提供资金，并获得2 - 3年的培训。博士前的学生将在研究生院的第二年致力于导师实验室，并研究衰老的神经科学。目前，没有其他机制可以为受训者提供资金，他们寻求专注于衰老的神经科学。