Role of methylation-dependent pathways in aging and stress

甲基化依赖性途径在衰老和压力中的作用

• 批准号: 10737022
• 负责人: Amy Karol Walker
• 金额: $ 63.05万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737022
• 关键词: Adult; Affect; Aging; Amino Acids; Animals; Automobile Driving; Biological; Biological Process; Biology; Caenorhabditis elegans; Carbon; Cell Nucleus; Cells; Chromatin; Collaborations; DNA Methylation; Data; Development; Disease; Engineering; Environment; Enzymes; Event; Family; Gene Expression; Gene Expression Profile; Genes; Genetic Transcription; Heat Stress Disorders; Heat-Shock Response; Individual; Intestines; Label; Link; Liver; Longevity; Mammals; Masks; Metabolic; Metabolic Pathway; Metabolism; Methionine; Methylation; Methyltransferase; Modeling; Molecular; Mutation; Neurons; Nucleotides; Pathway interactions; Phenotype; Phospholipids; Physiological; Polyamines; Process; Production; Protein Isoforms; Proteins; Proteome; Proteomics; RNA Interference; RNA methylation; Ribosomes; Role; S-Adenosylhomocysteine; S-Adenosylmethionine; Signaling Molecule; Site; Source; Specificity; Stress; Subcutaneous Tissue; System; Testing; Therapeutic Intervention; Time; Tissues; Vitamin B 12; Vitamin B6; biological adaptation to stress; chromatin modification; dietary; epigenetic regulation; experimental study; genome-wide; genomic locus; histone methylation; insight; knock-down; magnetic beads; novel; promoter; protein protein interaction; response; transcriptome sequencing

Metabolic cycles provide building blocks and energy currency for the cell, but also signaling molecules that regulate diverse physiological responses from differentiation to aging. The metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene expression in the stress response, a key part of the aging process. We have discovered that individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms regulating local production of SAM will produce novel insights into stress-responses and aging.

代谢周期为细胞提供构建模块和能量货币，同时也提供信号传导 调节从分化到衰老的多种生理反应的分子。这 代谢物 S-腺苷甲硫氨酸 (SAM) 就是这样一种用于调节基因的因子 应激反应中的表达，这是衰老过程的关键部分。我们发现 单个 SAM 合酶具有独特的作用，并推测揭示其机制 调节 SAM 的本地生产将为压力反应和衰老带来新的见解。

项目成果

Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0.

使用 WormCat 2.0 定义秀丽隐杆线虫中注释不良的基因的特征和保护。

• 发表时间: 2022-07-30
• 影响因子: 3.3
• 作者: Higgins, Daniel P;Weisman, Caroline M;Lui, Dominique S;D'Agostino, Frank A;Walker, Amy K
• 通讯作者: Walker, Amy K