Semantics and Services enabled Problem Solving Environment for Trypanosoma cruzi

语义和服务支持克氏锥虫问题解决环境

• 批准号: 7618493
• 负责人: AMIT P SHETH
• 金额: $ 37.35万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618493
• 关键词: Address; Adopted; Adoption; Adult; Area; Arts; Automobile Driving; Bioinformatics; Biological; Biological Sciences; Chagas Disease; Childhood; Collaborations; Communities; Complex; Controlled Vocabulary; Data; Data Set; Data Sources; Databases; Development; Diagnostic; Disease; Drops; Environment; Face; Generic Drugs; Genome; Genomics; Goals; Health; Heart Diseases; Human; Imagery; Immunology; Individual; Infection; Informatics; Information Management; Information Services; Internet; Knowledge; Language; Latin America; Learning; Leishmania major; Link; Manuals; Mass Spectrum Analysis; Metabolic Pathway; Methodology; Methods; Mind; Mining; Online Systems; Ontology; Organism; Outcome; Parasites; Pathogenesis; Phase; Problem Solving; Process; Proteomics; Protocols documentation; PubMed; Publications; Publishing; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Science; Semantics; Services; Software Tools; Solutions; Source; Sudden Death; System; Techniques; Technology; Testing; Trypanosoma brucei brucei; Trypanosoma cruzi; United States National Library of Medicine; Universities; Update; Vaccines; Work; base; biological systems; biomedical ontology; complex biological systems; computer based Semantic Analysis; computer science; design; fundamental research; human disease; improved; knowledge base; metabolomics; middle age; novel; novel strategies; pathogen; protein protein interaction; public health relevance; research and development; research study; syntax; therapeutic target; tool; usability

DESCRIPTION (provided by applicant): The study of complex biological systems increasingly depends on vast amounts of dynamic information from diverse sources. The scientific analysis of the parasite Trypanosoma cruzi (T.cruzi), the principal causative agent of human Chagas disease, is the driving biological application of this proposal. Approximately 18 million people, predominantly in Latin America, are infected with the T.cruzi parasite. As many as 40 percent of these are predicted eventually to suffer from Chagas disease, which is the leading cause of heart disease and sudden death in middle-aged adults in the region. Research on T. cruzi is therefore an important human disease related effort. It has reached a critical juncture with the quantities of experimental data being generated by labs around the world, due in large part to the publication of the T.cruzi genome in 2005. Although this research has the potential to improve human health significantly, the data being generated exist in independent heterogeneous databases with poor integration and accessibility. The scientific objectives of this research proposal are to develop and deploy a novel ontology-driven semantic problem-solving environment (PSE) for T.cruzi. This is in collaboration with the National Center for Biomedical Ontologies (NCBO) and will leverage its resources to achieve the objectives of this proposal as well as effectively to disseminate results to the broader life science community, including researchers in human pathogens. The PSE allows the dynamic integration of local and public data to answer biological questions at multiple levels of granularity. The PSE will utilize state-of- the-art semantic technologies for effective querying of multiple databases and, just as important, feature an intuitive and comprehensive set of interfaces for usability and easy adoption by biologists. Included in the multimodal datasets will be the genomic data and the associated bioinformatics predictions, functional information from metabolic pathways, experimental data from mass spectrometry and microarray experiments, and textual information from Pubmed. Researchers will be able to use and contribute to a rigorously curated T.cruzi knowledge base that will make it reusable and extensible. The resources developed as part of this proposal will be also useful to researchers in T.cruzi related kinetoplastids, Trypanosoma brucei and Leishmania major (among other pathogenic organisms), which use similar research protocols and face similar informatics challenges. PUBLIC HEALTH RELEVANCE: The scientific objective of this proposal is to develop and deploy a novel ontology-driven semantic problem-solving environment (PSE) for Trypanosoma cruzi, a parasite that infects approximately 18 million people, predominantly in Latin America. As many as 40 percent of those infected are predicted to eventually suffer from Chagas disease, the leading cause of heart disease and sudden death in middle-aged adults in the region. Facilitating T.cruzi research through the PSE, with the aim of identifying vaccine, diagnostic, and therapeutic targets, is an important human disease related endeavor.

描述（由申请人提供）：复杂生物系统的研究越来越取决于来自不同来源的大量动态信息。人类查加斯疾病的主要病原体的寄生虫锥虫（T.Cruzi）的科学分析是该提议的驱动生物学应用。大约有1800万人，主要在拉丁美洲，感染了T.Cruzi寄生虫。预计其中多达40％的人最终患有查加斯病，这是该地区中年成年人心脏病和猝死的主要原因。因此，关于克鲁兹河的研究是与人类疾病有关的重要工作。它达到了一个关键的关头，世界各地的实验室正在生成的实验数据数量，这在很大程度上是由于2005年发表了T.Cruzi基因组的发表。尽管这项研究有可能显着改善人类健康，但在独立的异构数据库中存在的数据存在于具有较差的整合和可及性。该研究建议的科学目标是为T.Cruzi开发和部署新型本体驱动的语义解决问题环境（PSE）。这是与国家生物医学本体论中心（NCBO）合作的，它将利用其资源来实现该提案的目标，并有效地将结果传播到更广泛的生命科学界，包括人类病原体的研究人员。 PSE允许本地数据和公共数据的动态整合以多个粒度层次回答生物学问题。 PSE将利用最先进的语义技术来有效查询多个数据库，并且同样重要的是，具有直观且全面的接口集，可用于生物学家，并易于采用生物学家。多模式数据集中包括基因组数据和相关的生物信息学预测，来自代谢途径的功能信息，来自质谱和微阵列实验的实验数据以及PubMed的文本信息。研究人员将能够使用并为严格策划的T.Cruzi知识库做出贡献，从而使其可重复使用和扩展。作为该提案的一部分而开发的资源也将对T.Cruzi相关的动力质体，Brucei和Leishmania Major的研究人员（除其他病原生物外），这些研究人员使用类似的研究方案并面临类似的信息信息挑战。公共卫生相关性：该提案的科学目标是为Crypanosoma Cruzi开发和部署一个新型的本体驱动的语义解决问题环境（PSE），这是一种寄生虫，该寄生虫感染了大约1800万人，主要是在拉丁美洲。预计被感染的人中有多达40％最终患有chagas病，这是该地区中年成年人心脏病和猝死的主要原因。通过PSE促进T.Cruzi研究，目的是确定疫苗，诊断和治疗靶标，是重要的人类疾病与人类疾病有关的重要努力。