Epidemiology of Brain Aging in the Very Old

老年人脑老化的流行病学

基本信息

批准号：
7383088
负责人：
LON Ray WHITE
金额：
$ 153.31万
依托单位：
KUAKINI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7383088
关键词：
Adopted Age Aging Alanine Alzheimer&apos s Disease Amino Acids Ankle Anti-Inflammatory Agents Anti-inflammatory Antibodies Apnea Appendix Architecture Archives Area Arginine Arousal Ascorbic Acid Asia Aspartic Acid Attention Autopsy Basal Ganglia Beds Blood Pressure Blood Vessels Blood specimen Body mass index Brain Brain Pathology C-reactive protein CETP gene Cardiovascular system Categories Central Sleep Apnea Cessation of life Characteristics Clinical Clinical Data Coffee Cognitive Collaborations Condition DNA Data Data Set Dementia Depth Diabetes Mellitus Diagnostic Dietary Fats Disease Early treatment Elderly Electrocardiogram End Point Endocrine Energy Intake Epidemiology Equilibrium Estradiol Etiology Evaluation Exons Factor Analysis Family Family member Fasting Fibrinogen Freezing Frequencies Functional disorder Funding Future Gait Genotype Glucose Glutamic Acid Glycine Gonadal Steroid Hormones Grant Heart Heart Rate Herpes Labialis Herpes zoster disease High Density Lipoproteins High Prevalence Hippocampus (Brain)Hour Impaired cognition Incidence Individual Infarction Infection Inflammation Insulin Intake Interleukin-6 Interview Japanese American Knowledge Laboratories Laboratory Infection Lead Lesion Leukocytes Lewy Body Disease Life Link Living Wills Longitudinal Studies Low-Density Lipoproteins Lymphocyte Count MRI Scans Magnetic Resonance Imaging Measurement Measures Memory impairment Metabolic Methods Motor Muscle Rigidity Nerve Degeneration Neurodegenerative Disorders Neurologic Neurologic Examination Nonagenarian Numbers Nutritional Operative Surgical Procedures Orthostatic Hypotension Outcome Parietal Parkinson Disease Parkinson&apos s Dementia Parkinsonian Disorders Participant Pathologic Pathology Pattern Perfusion Peripheral Vascular Diseases Pharmaceutical Preparations Phase Physical Function Plasma Polysomnography Population Positioning Attribute Posture Prevention strategy Principal Investigator Probability Proline Protocols documentation Psychotic Disorders Public Health Publishing Pulse Rates Range Rate Recording of previous events Relative (related person)Reporting Research Research Personnel Resources Respiration Risk Risk Factors Sampling Score Segmented Neutrophil Serine Serum Serum Albumin Severities Skinfold Thickness Sleep Slide Staging Subgroup Surface Telephone Telephone Interviews Testing Time Tissue Sample Tissue Stains Total Sugar Tremor Triceps Brachii Muscle Upper arm Uric Acid Variant Vascular Dementia Vitamin D Walking Work aged aging brain base blood lipid cardiovascular risk factor cognitive function cohort cysteine rich protein depressive symptoms design executive function fitness functional decline human CETP protein human very old age (85+)impaired glucose tolerance improved interest member men middle age mild neurocognitive impairment neocortical neuropathology neuropsychological prevent programs putamen research clinical testing research study saturated fat sleep abnormalities time interval tissue fixing

项目摘要

DESCRIPTION (provided by applicant): This application is for the continuation of the project, "Epidemiology of Brain Aging in the Very Old", a population-based longitudinal study of Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), mild cognitive impairment (MCI), and Parkinson's disease (PD). The cohort consists of Japanese-American men who have been followed in the Honolulu Heart Program (HHP) since 1965 and in the Honolulu-Asia Aging Study (HAAS) since 1991. Accrued resources include standardized measurements and observations from multiple prior examination cycles. Since 1991 these have included assessments of cognitive and motor function. Frozen blood samples and DNA are available for nearly all participants. Polysomnography studies and MRI scans are available on sub-samples, and extensive neuropathologic data are collected from ongoing, separately funded brain pathology projects. Two examination cycles were completed during the 2001-06 funding period. Identification of incident cases of AD, VaD, DLB, and PD, and extensive risk factor analyses resulted in several published reports. Neuropathologically confirmed mixed dementia was found to occur with high frequency. Unexpectedly, incidence of PD declined in the oldest subjects while dementia showed a steady rise. The central aims of the continuation will be: 1) estimation of incidence and clinical trajectories of decline for dementia, AD, VaD, DLB, PD, and MCI, between ages 87 and 105 years, 2) identification of additional risk factors and determinants for these conditions, with a special focus or relationships of cardiovascular factors to neurodegenerative conditions, and 3) correlation of clinical features and endpoints with neuropathological findings for participants who die and receive post-mortem examinations (supported by other grants). The target sample will be comprised of approximately 1,100 surviving participants when the initial examination begins. We expect to examine 767 (75%). Three examination cycles will be conducted at 1.5 year intervals, plus standardized telephone interviews with family informants at 6 month intervals. The youngest participant will be 87 years at the initial examination. The oldest at the final continuation cycle is expected be 112 years. These more frequent contacts are expected to enhance rapport with family members, improve our assessments of functional decline in the final months of life, and increase autopsy rates. The National Alzheimers Coordinating Center Uniform Data Set will be used for diagnostic criteria and methods and an expert neuropsychologist will join the team of core investigators. The unique design and resources of the HAAS will lead to improvements in our understanding of disease mechanisms for these conditions, and in turn, to strategies to prevent or delay their progression in the very old.

描述（由申请人提供）：本申请是为了“老年人大脑老化的流行病学”项目的延续，该项目是一项针对阿尔茨海默病（AD）、血管性痴呆（VaD）、路易痴呆的基于人群的纵向研究体（DLB）、轻度认知障碍（MCI）和帕金森病（PD）。该队列由日裔美国男性组成，自 1965 年以来一直在檀香山心脏计划 (HHP) 中进行跟踪，自 1991 年以来一直在檀香山亚洲老龄化研究 (HAAS) 中进行跟踪。积累的资源包括标准化测量和多个先前检查周期的观察结果。自 1991 年以来，这些评估包括认知和运动功能的评估。几乎所有参与者都可以获得冷冻血液样本和 DNA。可对子样本进行多导睡眠图研究和 MRI 扫描，并从正在进行的、单独资助的脑病理学项目中收集广泛的神经病理学数据。 2001-06 年资助期间完成了两个审查周期。对 AD、VaD、DLB 和 PD 事件病例的识别以及广泛的风险因素分析导致了几份已发表的报告。经神经病理学证实，混合性痴呆的发生频率很高。出乎意料的是，老年受试者的帕金森病发病率下降，而痴呆症发病率却稳步上升。延续的中心目标是：1) 估计 87 岁至 105 岁之间痴呆、AD、VaD、DLB、PD 和 MCI 的发病率和临床衰退轨迹，2) 确定其他风险因素和决定因素这些病症，特别关注心血管因素与神经退行性疾病的关系，以及 3) 死亡并接受尸检的参与者的临床特征和终点与神经病理学发现的相关性（由其他赠款支持）。初步检查开始时，目标样本将包括大约 1,100 名幸存参与者。我们预计检查 767 个（75%）。每隔 1.5 年将进行三个检查周期，并每隔 6 个月对家庭线人进行标准化电话访谈。初次检查时最年轻的参与者为87岁。最终延续周期中最古老的预计为 112 年。这些更频繁的接触有望增强与家人的融洽关系，改善我们对生命最后几个月功能衰退的评估，并提高尸检率。国家阿尔茨海默病协调中心统一数据集将用于诊断标准和方法，神经心理学家专家将加入核心研究人员团队。 HAAS 的独特设计和资源将提高我们对这些疾病机制的理解，进而制定预防或延缓老年人疾病进展的策略。