US-France Research Collaboration on Neuroimaging Studies of Alcoholism

美法酒精中毒神经影像学研究合作

• 批准号: 7574640
• 负责人: EDITH VIONI SULLIVAN
• 金额: $ 33.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7574640
• 关键词: Alcohol consumption; Alcoholism; Alcohols; Amnesia; Award; Brain; Chronic; Class; Clinical; Cognition; Cognitive; Collaborations; Data; Diffusion Magnetic Resonance Imaging; Disruption; Dysmorphology; France; Functional Magnetic Resonance Imaging; Heterogeneity; Human; Individual Differences; International; Laboratories; Magnetic Resonance Imaging; Measures; Memory; Motor; NIH Program Announcements; Nervous system structure; Neuraxis; Neuropsychological Tests; Neurosciences; Numbers; Nutritional; Nutritional status; Pattern; Process; Protocols documentation; Range; Recording of previous events; Research; Retrieval; Sampling; Severities; Site; Structure; Symptoms; Testing; Tissues; U-Series Cooperative Agreements; Variant; Wernicke-Korsakoff Syndrome; Withdrawal; Withdrawal Symptom; design; drinking; in vivo; neuroimaging; neuropathology; problem drinker; prospective; response; white matter

DESCRIPTION (provided by applicant): This application for a U01 cooperative agreement award is in response to Program Announcement (PA) number PAR-08-004, "International Research Collaboration on Alcohol and Alcoholism." The award will enable an international collaboration between two INSERM sites in France (Orsay and Caen) and our US neuroscience laboratories to investigate the consequences of chronic alcoholism on central nervous system structure and function. Our international collaboration provides a unique opportunity to examine within and across cultural variation a broad range of alcoholism-related neuropathology, measured in vivo with structural magnetic resonance imaging (MRI); brain microstructure, circuitry, and tissue quality, measured with diffusion tensor imaging (DTI); and selective brain functions, measured with functional MRI (fMRI) and neuropsychological tests of component processes of cognition, memory, and motor abilities. Human alcoholism is marked by considerable heterogeneity in its consequences on brain structure and function. This multi-site project will be an efficient approach for testing the overarching hypothesis that the heterogeneity of alcoholic consequences on brain structure and function are due substantially to individual differences in pattern of alcohol use, nutritional status, and history of withdrawal symptoms. In both the US and France, the target subject samples will span clinical manifestations from uncomplicated alcoholics to those with the profound amnesia of Korsakoff's Syndrome (KS) and will enable testing of hypotheses about factors contributing to the heterogeneity of alcoholism neuropathology. The Specific Aims of this proposal are to 1. Determine the influence of three classes of clinical variables-drinking pattern, nutritional history and status, and withdrawal history-on a) Alcoholism-related brain dysmorphology measured on legacy and prospective MRI data collected in the US and France from alcoholics with graded symptom severity b) Alcoholism-related white matter deficits measured on legacy and prospective DTI data collected in the US and France in alcoholics with graded symptom severity 2. Develop in the US and export to France fMRI and DTI protocols designed to examine and dissociate a) Cognitive frontocerebellar and frontal motor circuitry b) Limbic circuitry disruption to distinguish encoding from retrieval deficits in explicit memory.

描述（由申请人提供）：本 U01 合作协议奖励申请是对编号 PAR-08-004 的计划公告 (PA)“酒精和酒精中毒国际研究合作”的回应。该奖项将使法国的两个 INSERM 中心（奥赛和卡昂）与我们的美国神经科学实验室之间开展国际合作，以研究慢性酒精中毒对中枢神经系统结构和功能的影响。我们的国际合作提供了一个独特的机会来检查文化差异内和跨文化差异的广泛的酗酒相关神经病理学，通过结构磁共振成像（MRI）进行体内测量；使用弥散张量成像 (DTI) 测量的脑微观结构、电路和组织质量；以及选择性大脑功能，通过功能性磁共振成像 (fMRI) 和认知、记忆和运动能力组成过程的神经心理学测试来测量。人类酗酒对大脑结构和功能的影响具有相当大的异质性。这个多站点项目将成为测试总体假设的有效方法，即酒精对大脑结构和功能的影响的异质性很大程度上是由于饮酒模式、营养状况和戒断症状历史的个体差异造成的。在美国和法国，目标受试者样本将涵盖从无并发症的酗酒者到患有科萨科夫综合症（KS）的严重健忘症的临床表现，并将能够检验有关导致酒精中毒神经病理学异质性的因素的假设。该提案的具体目标是 1. 确定三类临床变量（饮酒模式、营养史和状态以及戒断史）对 a) 酒精中毒相关脑畸形的影响，该数据是根据收集的遗留和前瞻性 MRI 数据测量的。美国和法国的症状严重程度分级的酗酒者 b) 根据在美国和法国收集的症状严重程度分级的酗酒者的遗留和前瞻性 DTI 数据测量与酒精中毒相关的白质缺陷 2. 在美国开发并出口到法国fMRI 和 DTI 协议旨在检查和分离 a) 认知额小脑和额叶运动电路 b) 边缘电路破坏，以区分外显记忆中的编码和检索缺陷。