Training for a New Interdisciplinary Research Workforce in Regenerative Medicine

再生医学新的跨学科研究队伍的培训

• 批准号: 7669235
• 负责人: JOHN A KESSLER
• 金额: $ 9.09万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7669235
• 关键词: Academia; Achievement; Advisory Committees; Animal Disease Models; Animal Model; Antibodies; Antigens; Applied Research; Appointment; Area; Back; Basic Science; Biocompatible Materials; Bioethics; Biological; Biological Sciences; Biology; Biomedical Engineering; Biomedical Research; Biotechnology; Book Chapters; Books; Businesses; Case Study; Cell Therapy; Cell Transplants; Cells; Characteristics; Charge; Chemistry; Chicago; Child; Clinical; Clinical Medicine; Clinical Sciences; Clinical Trials; Cohort Studies; Collaborations; Commit; Committee Members; Communication; Communities; Community Services; Complement; Computers; Country; Data; Data Analyses; Dental; Development; Developmental Biology; Diagnostic; Discipline; Doctor of Philosophy; Drug Delivery Systems; Drug Industry; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Effectiveness; Elements; Emerging Technologies; Employment; Engineering; Ensure; Environment; Equilibrium; Ethical Issues; Ethics; Ethnic Origin; Evaluation; Event; Extracellular Matrix; Faculty; Family; Family Practice; Feedback; Fellowship; Female; Financial Support; Focus Groups; Forensic Sciences; Fostering; Funding; Funding Mechanisms; Funding Opportunities; Future; Gender; Genetic; Genomics; Goals; Government; Graduate Education; Grant; Growth; Hand; Healthcare; Hematopoietic System; Home environment; Hour; Human; Human Genome Project; Human Resources; Humanities; Image; Immune Tolerance; Immune response; Immunology; In Vitro; Individual; Industry; Influentials; Institutes; Institution; Instruction; Intellectual Property; Interdisciplinary Study; International; Internet; Internships; Interview; Job Application; Joints; Journals; Koreans; Laboratories; Laws; Lead; Leadership; Learning; Legal patent; Letters; Life; Logistics; Mails; Marketing; Measures; Mediation; Medical Device; Medical Research; Medicine; Mentors; Methodology; Methods; Microbiology; Minority; Modeling; Modification; Molecular; Monitor; Morals; Museums; Nanotechnology; Natural regeneration; Nature; Nervous System Trauma; Occupations; Oral; Organ; Orthopedics; Outcome; Participant; Pathway interactions; Patients; Perception; Performance; Physicians; Population; Positioning Attribute; Postdoctoral Fellow; Procedures; Process; Productivity; Program Development; Program Evaluation; Property; Public Policy; Publications; Published Comment; Publishing; Qualifying; Questionnaires; Race; Recommendation; Recruitment Activity; Regenerative Medicine; Regulation; Rehabilitation therapy; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Rest; Rewards; Robotics; Safety; Schedule; Schools; Science; Scientist; Series; Services; Side; Societies; Source; Stem Cell Research; Stem cell transplant; Stem cells; Structure; Student Selections; Students; Supervision; Surface; Surveys; Talents; Techniques; Technology; Technology Transfer; Therapeutic; Thinking; Tissue Engineering; Tissues; Toxicology; Training; Training Programs; Translating; Translational Research; Transplantation; United States National Institutes of Health; Universities; User-Computer Interface; Visit; Woman; Work; Wound Healing; Writing; adult stem cell; base; body system; career; career development; cell mediated immune response; clinical practice; design; embryonic stem cell; experience; extracellular; falls; feeding; follow-up; follower of religion Jewish; gene replacement therapy; gene therapy; graduate student; grasp; human stem cells; in vivo; interdisciplinary approach; interest; intimate behavior; journal article; medical schools; meetings; member; nanomaterials; nanomedicine; nanoparticle; nanopattern; nanoscience; nerve stem cell; novel strategies; organ regeneration; peer; physical science; pluripotency; posters; pre-doctoral; programs; prospective; reconstitution; regenerative; relating to nervous system; repaired; responsible research conduct; scaffold; science and society; skills; skills training; social; soft drink; stem cell biology; success; symposium; synthetic biology; tissue regeneration; tool

DESCRIPTION (provided by applicant): Regenerative medicine is one of the great biomedical challenges of this century, requiring research at the interface of the physical and life sciences as well as engineering. Cell-based therapies for tissue and organ regeneration will involve not only stem cell biology but also the crafting of bioactive matrices to support tissue growth. This will require cutting- edge supramolecular chemistry, nanotechnology, and micro scale process engineering. In addition, understanding and regulating immune responses to regenerated tissues will be essential for long term survival and function of reconstituted organs. The most effective regenerative strategies will include not only cell-based therapies but also the development of man-machine interfaces, particularly in the case of the damaged nervous system. No single discipline is likely to be able to overcome all of the obstacles to developing techniques for repairing or regenerating damaged tissues and organs. It is therefore necessary to design and implement programs that fuse disparate disciplines into a unified effort to achieve the goals of regenerative medicine. The goal of this training program is to provide predoctoral and postdoctoral trainees with integrated interdisciplinary training in this area. The training faculty members represent 10 different departments/divisions in the Feinberg School of Medicine, 3 departments in the McCormick School of Engineering and Applied Sciences, 2 departments/divisions at Children's Medical Research Center, and 1 department at the Rehabilitation Institute of Chicago. Collectively the preceptors include 5MD PhDs, 12 PhDs, and 3 MDs. The faculty has been carefully constituted to be able to provide oversight in critical areas for the field including stem cell and developmental biology, materials science and nanomedicine, extracellular matrix, immune tolerance to tissues, and neural engineering and robotics. It is anticipated that trainees will be drawn from six unified graduate programs at Northwestern University. Predoctoral trainees selected for the program will fulfill the rigorous requirements for the granting of the PhD degree in their respective programs. Due to the interdisciplinary nature of this research area, the training program core curriculum will have additional unique and non-traditional aspects in which both predoctoral and postdoctoral trainees will participate. The overall theme involves the wedding of bioengineering and materials science with stem cell biology and animal modeling. The goal is to train a cadre of investigators with the requisite interdisciplinary skills necessary both to overcome the barriers to organ and tissue regeneration and to translate advances in the life and physical sciences into clinical medicine.

描述（由申请人提供）：再生医学是本世纪的巨大生物医学挑战之一，需要在物理和生命科学和工程学的界面进行研究。基于细胞的组织和器官再生的疗法不仅涉及干细胞生物学，而且还涉及生物活性基质以支持组织生长的制作。这将需要超边的超分子化学，纳米技术和微型尺度工艺工程。此外，了解和调节对再生组织的免疫反应对于长期生存和重建器官的功能至关重要。最有效的再生策略不仅包括基于细胞的疗法，还包括人机界面的发展，尤其是在受损的神经系统的情况下。没有任何纪律能够克服开发修复或再生受损组织和器官的技术的所有障碍。因此，有必要设计和实施将不同学科融合到实现再生医学目标的统一努力中的计划。该培训计划的目的是在该领域为综合跨学科培训提供前学和博士后学员。培训教师代表Feinberg医学院的10个不同部门/部门，麦考密克工程和应用科学学院的3个部门，儿童医学研究中心的2个部门/部门以及芝加哥康复研究所的1个部门。总体上，受体包括5MD博士学位，12个PHD和3 MDS。该教师经过精心构成，能够在该领域的关键领域提供监督，包括干细胞和发育生物学，材料科学和纳米医学，细胞外基质，对组织的免疫耐受性以及神经工程和机器人技术。预计将从西北大学的六个统一研究生课程中吸引学员。为该计划选择的托管前学员将满足其各自计划中授予博士学位的严格要求。由于该研究领域的跨学科性质，培训计划的核心课程将具有其他独特和非传统的方面，在这些方面中，这些方面和博士后学员都将参与其中。总体主题涉及使用干细胞生物学和动物建模的生物工程和材料科学的婚礼。目的是培训一群调查人员的干部，以克服器官和组织再生的障碍以及将生活和物理科学的进步转化为临床医学所需的必要跨学科技能。

项目成果

Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases.

• DOI: 10.1002/term.273
• 发表时间: 2010-12
• 期刊: Journal of tissue engineering and regenerative medicine
• 影响因子: 3.3
• 作者: Webber MJ;Han X;Murthy SN;Rajangam K;Stupp SI;Lomasney JW
• 通讯作者: Lomasney JW

High resolution three-dimensional imaging: Evidence for cell cycle reentry in regenerating skeletal muscle.

• DOI: 10.1002/dvdy.22530
• 发表时间: 2011-05
• 期刊: DEVELOPMENTAL DYNAMICS
• 影响因子: 2.5
• 作者: Calve, Sarah;Simon, Hans-Georg
• 通讯作者: Simon, Hans-Georg

The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells.

• DOI: 10.1002/stem.626
• 发表时间: 2011-05
• 期刊: STEM CELLS
• 影响因子: 5.2
• 作者: Bissonnette, Christopher J.;Lyass, Ljuba;Bhattacharyya, Bula J.;Belmadani, Abdelhak;Miller, Richard J.;Kessler, John A.
• 通讯作者: Kessler, John A.

A transitional extracellular matrix instructs cell behavior during muscle regeneration.

• DOI: 10.1016/j.ydbio.2010.05.007
• 发表时间: 2010-08-01
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Calve, Sarah;Odelberg, Shannon J.;Simon, Hans-Georg
• 通讯作者: Simon, Hans-Georg