Center for Clinical and Translational Sciences (CCTS)

临床和转化科学中心 (CCTS)

• 批准号: 10707570
• 负责人: DANIEL D KARP
• 金额: $ 7.15万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10707570
• 关键词: Acceleration; Address; American; Area; Award; Basic Science; Biomedical Research; Cancer Center; Childhood; Chronic lung disease; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Community Health; Conduct Clinical Trials; Country; Data; Doctor of Medicine; Education; Elderly; Environment; First Independent Research Support and Transition Awards; Fostering; Goals; Health; Health Sciences; Healthcare; Hispanic; Hospitals; Individual; Informatics; Institute of Medicine (U.S.); Institution; Institutional Review Boards; Knowledge; Learning; Lesbian Gay Bisexual Transgender Queer; Malignant Neoplasms; Medical; Medical Faculty; Medical Staff; Medical center; Medicine; Methodist Church; Methods; Mexican Americans; Multi-Institutional Clinical Trial; National Center for Advancing Translational Sciences; Patients; Physicians; Population; Population Heterogeneity; Process; Reporting; Research; Research Contracts; Research Personnel; Resources; Rice; Rural; Rural Health; Schools; Science; Services; Site; Solid; South Texas; Texas; Training; Translational Research; Translations; Tuberculosis; Universities; Work; Workforce Development; base; bench to bedside; biobank; cancer care; cancer clinical trial; clinical care; clinical center; clinical data warehouse; college; community engagement; computer science; economic disparity; health training; improved; innovation; inter-institutional; multidisciplinary; next generation; novel; outreach; patient registry; population based; programs; skills; translational pipeline; translational scientist

Contact PD/PI: McPherson, David D. In the first awarded CTSA class, the Center for Clinical and Translational Sciences (CCTS) formed the first multiple-institution CTSA, with The University of Texas Health Science Center at Houston (UTHSC-H) and The University of Texas M. D. Anderson Cancer Center (UT MDACC). Since its inception the CCTS has been achieving the primary goal of the Clinical and Translational Sciences Award (CTSA) program: to accelerate research to transform healthcare and train the next generation of translational scientists. Our initial proposal was about bringing individuals and resources together, educating investigators, and building teams. In our 2011 renewal we described our Lowering-The-Barriers program, which focused on removing a large number of impediments through initiatives such as IRB reciprocity, standard research contracts and subcontracts, clinical data warehouses, patient registries, and biobanks. Our efforts have been successful and aligned with the national CTSA program. In this cycle, we bring in 3 new partner institutions to broaden and diversify our CTSA: The University of Texas Health Science Center at Tyler (northeast Texas, rural, economically disadvantaged), Rice University (with strengths in computer science, education, and team science), and The University of Texas Rio Grande Valley (south Texas, education and physician resources to help our nearby Brownsville Clinical Research Unit perform clinical trials). Together we will effect 5 strategic goals: Strategic Goal 1: To provide our investigators, staff, trainees, and scholars with the skills and knowledge necessary to advance discoveries and their translation in the new environment of clinical and translational research (Workforce Development). Strategic Goal 2: To collaborate with all of our stakeholders in a mutually beneficial way to advance translation by furthering engagement and team science (Collaboration/Engagement). Strategic Goal 3: To integrate pediatric and geriatric patients, Hispanic patients with cancer, and the LGBTQ+ community into the full spectrum of clinical and translational research (Integration). Strategic Goal 4: To advance translational science by providing novel processes, increasing efficiency, and streamlining research (Methods/Processes). Strategic Goal 5. To create and apply innovative informatics solutions to advance translational research, train the CTSA workforce, disseminate best practices, engage communities and integrate clinical and basic research data (Informatics). Page 373 Project Summary/Abstract Contact PD/PI: McPherson, David D. The CCTS will support bidirectional translational research, moving discoveries from the bench to the bedside, by training a capable workforce using our unique multidisciplinary translational teams and innovative educational programs. Our hub will serve to foster high-quality clinical research, develop best practices in team-based translations, participate in inter-institutional data-sharing, and function as an efficient site for multi- site clinical trials in our large, diverse populations. The CCTS, through its novel programs and resources, will remain an important contributor to achieving the goals of the national consortium. Page 374

联系 PD/PI：McPherson、David D. 在首届 CTSA 类别中，临床和转化科学中心 (CCTS) 组建了第一个 多机构 CTSA，包括德克萨斯大学休斯顿健康科学中心 (UTHSC-H) 和 德克萨斯大学 MD 安德森癌症中心 (UT MDACC)。自CCTS成立以来， 实现临床和转化科学奖 (CTSA) 计划的主要目标：加速 旨在改变医疗保健并培训下一代转化科学家的研究。我们最初的建议 旨在将个人和资源聚集在一起，教育调查人员并建立团队。在我们的 2011 年更新中，我们描述了“降低障碍”计划，该计划的重点是消除大量 通过 IRB 互惠、标准研究合同和分包合同、临床 数据仓库、患者登记处和生物库。我们的努力是成功的，并且与 国家 CTSA 计划。在此周期中，我们引入了 3 个新的合作伙伴机构，以扩大我们的业务范围并使其多元化 CTSA：位于泰勒的德克萨斯大学健康科学中心（德克萨斯州东北部，农村，经济 弱势）、莱斯大学（在计算机科学、教育和团队科学方面具有优势）、 和德克萨斯大学里奥格兰德河谷分校（德克萨斯州南部）的教育和医师资源 帮助我们附近的布朗斯维尔临床研究单位进行临床试验）。我们将一起实现 5 战略目标： 战略目标 1：为我们的研究人员、工作人员、受训人员和学者提供 在新环境中推进发现及其转化所需的技能和知识 临床和转化研究（劳动力发展）。战略目标2：与所有人合作 我们的利益相关者以互惠互利的方式通过进一步参与和推进翻译 团队科学（协作/参与）。战略目标 3：整合儿科和老年科 患者、西班牙裔癌症患者和 LGBTQ+ 群体进入全方位的临床治疗 和转化研究（整合）。战略目标 4：通过以下方式推进转化科学： 提供新颖的流程、提高效率并简化研究（方法/流程）。 战略目标 5. 创建并应用创新信息学解决方案以推进转化 研究、培训 CTSA 员工、传播最佳实践、吸引社区并整合 临床和基础研究数据（信息学）。 第373页 项目概要/摘要 联系 PD/PI：McPherson、David D. CCTS 将支持双向转化研究，将发现从实验室转移到临床， 通过利用我们独特的多学科翻译团队和创新技术培训一支有能力的员工队伍 教育计划。我们的中心将致力于促进高质量的临床研究，开发最佳实践 基于团队的翻译，参与机构间数据共享，并作为多方翻译的高效站点 在我们庞大且多样化的人群中进行临床试验。 CCTS 通过其新颖的计划和资源，将 仍然是实现国家联盟目标的重要贡献者。 第374页

项目成果

Prediction of Brain Metastases Development in Patients With Lung Cancer by Explainable Artificial Intelligence From Electronic Health Records.

通过电子健康记录中的可解释人工智能预测肺癌患者脑转移的发展。

• DOI: 10.1200/cci.22.00141
• 发表时间: 2023
• 期刊: JCO clinical cancer informatics
• 影响因子: 4.2
• 作者: Li,Zhao;Li,Rongbin;Zhou,Yujia;Rasmy,Laila;Zhi,Degui;Zhu,Ping;Dono,Antonio;Jiang,Xiaoqian;Xu,Hua;Esquenazi,Yoshua;Zheng,WJim
• 通讯作者: Zheng,WJim

Mindfulness as a predictor of cognitive-behavioral therapy outcomes in inner-city adults with posttraumatic stress and substance dependence.

正念作为患有创伤后应激和物质依赖的市中心成年人认知行为治疗结果的预测因子。

• DOI: 10.1016/j.addbeh.2019.106283
• 发表时间: 2020
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Vujanovic,AnkaA;Smith,LiaJ;Green,Charles;Lane,ScottD;Schmitz,JoyM
• 通讯作者: Schmitz,JoyM

Different strokes: differences in the characteristics and outcomes of BCVI and non-BCVI strokes in trauma patients.

不同的中风：创伤患者 BCVI 和非 BCVI 中风的特征和结果的差异。

• DOI: 10.1136/tsaco-2020-000457
• 发表时间: 2020
• 期刊: Trauma surgery & acute care open
• 影响因子: 2
• 作者: McNutt,MichelleK;Slovacek,Cedar;Rosenbaum,David;Indupuru,HariKishanReddy;Zhang,Xu;Cotton,BryanA;Harvin,John;Wade,CharlesE;Savitz,SeanI;Kao,LillianS
• 通讯作者: Kao,LillianS

Screening Children with a Family History of Central Congenital Hypoventilation Syndrome.

筛查有中枢性先天性通气不足综合征家族史的儿童。

• DOI: 10.1155/2020/2713606
• 发表时间: 2020
• 期刊: Case reports in pediatrics
• 影响因子: 0.9
• 作者: Emanuel,Hina;Rennie,Kimberly;Macdonald,Kelly;Yadav,Aravind;Mosquera,RicardoA
• 通讯作者: Mosquera,RicardoA

Invasive Haemophilus influenza Type b in an Infant During the COVID-19 Pandemic: The Return of Diseases We Hoped Never to See Again….

COVID-19 大流行期间婴儿的 b 型侵袭性流感嗜血杆菌：我们希望再也不会看到的疾病卷土重来……。

• DOI: 10.1097/inf.0000000000003343
• 发表时间: 2022
• 期刊: The Pediatric infectious disease journal
• 作者: Tabarani,Christy;Fletcher,StephenA;Heresi,GloriaP;Wootton,SusanH
• 通讯作者: Wootton,SusanH