Center for Clinical and Translational Sciences (CCTS)

临床和转化科学中心 (CCTS)

基本信息

批准号：
10654064
负责人：
DANIEL D KARP
金额：
$ 290.31万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-24 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10654064
关键词：
Acceleration Address American Area Award Basic Science Biomedical Research Cancer Center Childhood Chronic lung disease Clinical Research Clinical Sciences Clinical Trials Clinical and Translational Science Awards Collaborations Communities Community Health Conduct Clinical Trials Country Data Doctor of Medicine Education Elderly Environment First Independent Research Support and Transition Awards Fostering Goals Health Health Sciences Healthcare Hispanic Hospitals Individual Informatics Institute of Medicine (U.S.)Institution Institutional Review Boards Knowledge Learning Lesbian Gay Bisexual Transgender Queer Malignant Neoplasms Medical Medical Faculty Medical Staff Medical center Medicine Methodist Church Methods Mexican Americans Multi-Institutional Clinical Trial National Center for Advancing Translational Sciences Patients Physicians Population Population Heterogeneity Process Reporting Research Research Contracts Research Personnel Resources Rice Rural Rural Health Schools Science Services Site Solid South Texas Texas Training Translational Research Translations Tuberculosis Universities Work Workforce Development base bench to bedside biobank cancer care cancer clinical trial clinical care clinical center clinical data warehouse college community engagement computer science economic disparity health training improved innovation inter-institutional multidisciplinary next generation novel outreach patient registry population based programs skills translational pipeline translational scientist

项目摘要

Contact PD/PI: McPherson, David D. In the first awarded CTSA class, the Center for Clinical and Translational Sciences (CCTS) formed the first multiple-institution CTSA, with The University of Texas Health Science Center at Houston (UTHSC-H) and The University of Texas M. D. Anderson Cancer Center (UT MDACC). Since its inception the CCTS has been achieving the primary goal of the Clinical and Translational Sciences Award (CTSA) program: to accelerate research to transform healthcare and train the next generation of translational scientists. Our initial proposal was about bringing individuals and resources together, educating investigators, and building teams. In our 2011 renewal we described our Lowering-The-Barriers program, which focused on removing a large number of impediments through initiatives such as IRB reciprocity, standard research contracts and subcontracts, clinical data warehouses, patient registries, and biobanks. Our efforts have been successful and aligned with the national CTSA program. In this cycle, we bring in 3 new partner institutions to broaden and diversify our CTSA: The University of Texas Health Science Center at Tyler (northeast Texas, rural, economically disadvantaged), Rice University (with strengths in computer science, education, and team science), and The University of Texas Rio Grande Valley (south Texas, education and physician resources to help our nearby Brownsville Clinical Research Unit perform clinical trials). Together we will effect 5 strategic goals: Strategic Goal 1: To provide our investigators, staff, trainees, and scholars with the skills and knowledge necessary to advance discoveries and their translation in the new environment of clinical and translational research (Workforce Development). Strategic Goal 2: To collaborate with all of our stakeholders in a mutually beneficial way to advance translation by furthering engagement and team science (Collaboration/Engagement). Strategic Goal 3: To integrate pediatric and geriatric patients, Hispanic patients with cancer, and the LGBTQ+ community into the full spectrum of clinical and translational research (Integration). Strategic Goal 4: To advance translational science by providing novel processes, increasing efficiency, and streamlining research (Methods/Processes). Strategic Goal 5. To create and apply innovative informatics solutions to advance translational research, train the CTSA workforce, disseminate best practices, engage communities and integrate clinical and basic research data (Informatics). Page 373 Project Summary/Abstract Contact PD/PI: McPherson, David D. The CCTS will support bidirectional translational research, moving discoveries from the bench to the bedside, by training a capable workforce using our unique multidisciplinary translational teams and innovative educational programs. Our hub will serve to foster high-quality clinical research, develop best practices in team-based translations, participate in inter-institutional data-sharing, and function as an efficient site for multi- site clinical trials in our large, diverse populations. The CCTS, through its novel programs and resources, will remain an important contributor to achieving the goals of the national consortium. Page 374

联系PD/PI：McPherson，David D. 在第一个授予的CTSA班级中，临床和转化科学中心（CCTS）形成了第一个多个机构CTSA，德克萨斯大学健康科学中心（UTHSC-H）和德克萨斯大学M. D.安德森癌症中心（UT MDACC）。自成立以来，CCT一直是实现临床和转化科学奖（CTSA）计划的主要目标：加速研究改造医疗保健并培训下一代转化科学家的研究。我们的最初建议关于将个人和资源召集在一起，教育调查人员和建立团队。在我们的 2011年更新，我们描述了我们的降低驻扎计划，该计划的重点是删除大量通过IRB互惠，标准研究合同和分包合同，临床的障碍数据仓库，患者注册和生物库。我们的努力已经成功，并与国家CTSA计划。在这个周期中，我们引入了3个新的合作伙伴机构，以扩大和多样化我们的 CTSA：泰勒分校的德克萨斯大学健康科学中心（德克萨斯州东北部，农村，经济上不利），莱斯大学（在计算机科学，教育和团队科学方面具有优势），以及德克萨斯大学里奥格兰德分校（南德克萨斯州，教育和医师资源帮助我们附近的布朗斯维尔临床研究部门进行临床试验）。我们将共同实现5 战略目标：战略目标1：向我们的研究人员，员工，学员和学者提供在新的环境中提高发现及其翻译所需的技能和知识临床和转化研究（劳动力发展）。战略目标2：与所有人合作利益相关者以互惠互利的方式来推动参与和团队科学（协作/参与）。战略目标3：整合小儿和老年患者，西班牙裔癌症患者和LGBTQ+社区进入临床全部范围和翻译研究（整合）。战略目标4：通过提供新颖的过程，提高效率和简化研究（方法/过程）。战略目标5。创建和应用创新的信息学解决方案以推动翻译研究，培训CTSA劳动力，传播最佳实践，参与社区并整合临床和基础研究数据（信息学）。第373页项目摘要/摘要联系PD/PI：McPherson，David D. CCT将支持双向翻译研究，将发现从长凳转移到床边，通过使用我们独特的多学科翻译团队和创新的培训能力的劳动力教育计划。我们的枢纽将有助于培养高质量的临床研究，开发最佳实践基于团队的翻译，参与机构间数据共享，并充当多种多样的网站在我们大型，多样化的人群中进行现场临床试验。 CCT通过其新颖的程序和资源将仍然是实现国家财团目标的重要贡献者。第374页