Ultra-fast imaging for the safe delivery of electron FLASH radiation therapy

用于安全实施电子闪光放射治疗的超快速成像

• 批准号: 10708158
• 负责人: Petr Bruza
• 金额: $ 100万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708158
• 关键词: Adjuvant; Animals; Calibration; Characteristics; Clinical; Clinical Trials; Collaborations; Commercial grade; Complex; Computer software; Deposition; Detection; Devices; Documentation; Dose; Dose Limiting; Dose Rate; Electron Beam; Electronics; Electrons; Engineering; Ensure; Environment; Event; Goals; Grant; Human; Image; Industry; Interruption; Kansas; Location; Measures; Medical; Medical center; Medicine; Methods; Modification; Monitor; Normal tissue morphology; Operative Surgical Procedures; Output; Patients; Performance; Persons; Phase; Physics; Physiologic pulse; Positioning Attribute; Protons; Radiation; Radiation Monitoring; Radiation Oncology; Radiation therapy; Research; Resolution; Resources; Risk; Running; Safety; Scanning; Schools; Sea; Series; Speed; Structure; Synchrocyclotron; System; Testing; Tissues; Toxic effect; Translations; Treatment outcome; United States; Universities; Validation; Work; cancer therapy; chemotherapy; cherenkov imaging; clinical implementation; clinical research site; clinical translation; conventional therapy; curative treatments; design; detection method; detection platform; dosimetry; efficacy clinical trial; image guided; imaging system; improved; irradiation; maltreatment; millisecond; performance tests; preclinical study; proton beam; prototype; risk minimization; risk mitigation; sensor; spatiotemporal; tool; translation to humans; translational potential; treatment planning; tumor

Abstract Radiation therapy is a supplementary curative treatment used adjuvant with most surgery and chemotherapy, being delivered to nearly 1 out of every 4 people in their lifetime. While image guidance and conformal planning reduced the dose to healthy tissue, there is still a substantial risk of tissue damage that sets the upper limit of dose deposited to the tumor. Recently the minimization of healthy tissue damage was demonstrated to occur when ultra-high dose rates (UHDR) were used for irradiation, known as the FLASH effect. UHDR are defined as a complex set of high average dose rates (>40 Gy/s), instantaneous dose rates (>106 Gy/s), total dose values (>8Gy) and temporal pulse structures. FLASH promises a reduction in normal tissue toxicity by 20-50% and our clinical site partner Dartmouth-Hitchcock, has been the first to demonstrate routine weekly delivery of FLASH on a clinically used linac. This modification shows enormous translational potential to deliver electron FLASH (eFLASH) in any radiotherapy center using existing systems. However, while most research in the field is focused on elucidating the radiobiological mechanisms of FLASH, work towards mitigating the risks of FLASH is largely untouched, yet will be pivotal for wider clinical implementation. New techniques for detection monitoring of radiation need to be developed due to the millisecond timescales at which FLASH operates which make traditional methods unsuitable. In this project, we have leveraged our camera platform, BeamSite®, the world’s first video system for radiotherapy, now FDA cleared and in use clinically, to developed BeamSite-ULTRA, specifically for imaging FLASH. In our Phase I grant, we successfully demonstrated the ability to image at the high frame rates and transfer speeds necessary to capture a single beam pulse energy in phantoms and on tissue. In this Phase II, we will advance BeamSite-ULTRA as a robust, manufacturable, and FDA clearable commercial system. We will quantify both spatial and temporal pulse structures, demonstrate beam-on and gating-off potential of the system, and establish the capabilities in both proton and electron FLASH clinical settings. The work includes an extensive team of industry and academic medicine colleagues, using the eFLASH resources at Dartmouth-Hitchcock Medical Center and the proton treatment facilities at the University of Kansas Medical Center.

抽象的 放射治疗是一种补充治疗疗法，用于调整大多数手术和化学疗法， 一生中每4个人中几乎可以送达1人。而图像指导和保形计划 降低了对健康组织的剂量，仍然存在组织损伤的巨大风险，使上限的上限 沉积在肿瘤上的剂量。最近证明健康组织损伤的最小化发生了 当使用超高剂量率（UHDR）进行辐照时，称为闪光效应。 UHDR定义为 一组复杂的高平均剂量率（> 40 Gy/s），瞬时剂量率（> 106 Gy/s），总剂量值 （> 8Gy）和临时脉冲结构。 Flash承诺将正常组织毒性降低20-50％，而我们 临床现场合作伙伴达特茅斯 - 希奇科克（Dartmouth-Hitchcock 临床使用的Linac。这种修改显示了传递电子闪光的巨大翻译潜力 （EFLASH）使用现有系统的任何放射疗法中心。但是，尽管该领域的大多数研究都集中在 关于阐明闪光的放射生物学机制，致力于减轻闪光的风险很大程度上是 未经触摸，但对于更广泛的临床实施将是关键的。用于检测监视的新技术 由于闪光灯的操作，需要开发辐射 传统方法不合适。在这个项目中，我们利用了我们的相机平台Beamsite®，世界的 第一个用于放射疗法的视频系统，如今已清除FDA并在临床上使用，用于开发Beamsite-ultra， 专门用于成像闪光灯。在我们阶段的授予中，我们成功地证明了在 捕获幻像和捕获单个梁脉冲能所需的高帧速率和传输速度 组织。在这二阶段中，我们将推动良好，制造和FDA可清除 商业系统。我们将量化空间和临时脉冲结构，展示梁孔，并且 系统的门控潜力，并在质子和电子闪光灯临床上建立功能 设置。这项工作包括使用Eflash的广泛的行业和学术医学同事团队 达特茅斯 - 希区柯克医疗中心的资源和堪萨斯大学的质子治疗设施 医疗中心。

项目成果

Two-dimensional time-resolved scintillating sheet monitoring of proton pencil beam scanning FLASH mouse irradiations.

质子笔形束扫描 FLASH 小鼠照射的二维时间分辨闪烁片监测。

• DOI: 10.1002/mp.17049
• 发表时间: 2024
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Kanouta,Eleni;Bruza,Petr;Johansen,JacobGraversen;Kristensen,Line;Sørensen,BritaSingers;Poulsen,PerRugaard
• 通讯作者: Poulsen,PerRugaard