Developmental Research Program

发展研究计划

• 批准号: 10708579
• 负责人: Ryan C Fields
• 金额: $ 23.02万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-28 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708579
• 关键词: Area; Award; Cancer Biology; Cancer Research Project; Clinical; Clinical Trials; Collaborations; Development; Disabled Persons; Early Diagnosis; Epidemiology; Extramural Activities; Faculty; Fostering; Funding; Future; Goals; Grant; Group Meetings; Image; Institution; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentors; Minority; Minority Groups; Minority Recruitment; Peer Review; Prevention; Program Research Project Grants; Refractory; Research; Research Personnel; Research Project Grants; Translating; Translational Research; Underrepresented Minority; Universities; Washington; Woman; Work; Writing; anticancer research; cancer prevention; career; design; improved; innovation; meetings; minority investigator; pancreas development; pancreatic cancer patients; programs; recruit; success

PROJECT SUMMARY The goal of the SPORE in Pancreatic Cancer Developmental Research Program (DRP) is to recruit and support developmental research projects in pancreatic cancer for future incorporation as full SPORE projects or as the basis for applications for other nationally competitive peer-reviewed funding. The types of pancreatic cancer research projects that will be supported include basic, translational, clinical, epidemiologic, and cancer prevention. Projects supported under the DRP will expand the scope of translational research and increase the number of investigators committed to pancreatic cancer research. The DRP is open to institutions participating in the SPORE (WUSM, UPenn) and any of their collaborators. The DRP will work in tandem with the Career Enhancement Program (CEP) to assist in developing junior investigators and recruiting/mentoring minority investigators. These objectives will be accomplished by performing four specific aims. Aim 1: Support the development of pancreatic cancer research projects for future incorporation as full SPORE projects or for new independent peer-reviewed funding. The DRP will solicit new research projects annually. In addition to NCI funds, a total of $375,000 in institutional support has been committed in support of the DRP. DRP awards will provide up to $75,000 for 1 year, with a competitive renewal allowed for a second year of funding. Two to three awards per year are anticipated. Institutional funds will make the NCI funds ($25,000/year) committed to underrepresented minorities equivalent to other DRP awards. Aim 2: Foster collaborations between basic and clinical researchers. The DRP directors will facilitate interactions between basic and clinical researchers through shared weekly meetings, the annual SPORE retreat, and small group meetings. Aim 3: Mentor junior faculty and new faculty involved in pancreatic cancer research. All investigators submitting applications to the DRP will receive a written scientific and statistical review, and the DRP directors will be available to discuss the projects in detail. Where appropriate, mentors will be identified to work with junior faculty or collaborate with faculty whose primary research area is outside of pancreatic cancer. All DRP awardees will present their research progress to the SPORE steering committee twice per year. Aim 4: Promote the participation of women, minorities, and disabled investigators in pancreatic cancer research and facilitate the recruitment of minorities into clinical pancreatic cancer trials. The DRP directors will implement initiatives that enhance the participation of women, minorities, and disabled persons in SPORE clinical trials and promote the participation of diverse groups in pancreatic cancer research. Impact: The proposed work will improve our understanding of pancreatic cancer biology and will identify new strategies for early detection, prevention, imaging, and treatment for this refractory malignancy.

项目概要 SPORE 胰腺癌发展研究计划 (DRP) 的目标是招募和支持 胰腺癌的发展研究项目，以便将来纳入完整的 SPORE 项目或作为 申请其他国家竞争性同行评审资金的基础。胰腺癌的类型 将支持的研究项目包括基础、转化、临床、流行病学和癌症 预防。 DRP 支持的项目将扩大转化研究的范围并增加 许多研究人员致力于胰腺癌研究。 DRP 向参与机构开放 SPORE（WUSM、宾夕法尼亚大学）及其任何合作者。 DRP 将与职业部门协同工作 增强计划（CEP），协助培养初级研究人员和招募/指导少数群体 调查人员。这些目标将通过执行四个具体目标来实现。 目标 1：支持胰腺癌研究项目的发展，以便将来全面纳入 SPORE 项目或新的独立同行评审资金。 DRP将征集新的研究项目 每年。除了 NCI 资金外，还承诺提供总计 375,000 美元的机构支持，以支持 DRP。 DRP 奖励将提供一年高达 75,000 美元的奖励，并允许第二次竞争性续约 资助年份。预计每年有两到三个奖项。机构资金将使 NCI 资金 （25,000 美元/年）致力于为代表性不足的少数群体提供相当于其他 DRP 奖项的资金。 目标 2：促进基础研究人员和临床研究人员之间的合作。 DRP 董事将协助 基础研究人员和临床研究人员之间通过每周共享的会议、年度 SPORE 静修会进行互动， 和小组会议。 目标 3：指导参与胰腺癌研究的初级教师和新教师。所有调查员 向 DRP 提交申请将收到书面科学和统计审查，并且 DRP 主任 将可以详细讨论这些项目。在适当的情况下，将确定导师与初级人员一起工作 教师或与主要研究领域在胰腺癌以外的教师合作。所有 DRP 获奖者 每年两次向 SPORE 指导委员会介绍他们的研究进展。 目标 4：促进女性、少数族裔和残疾研究人员参与胰腺癌研究 研究并促进招募少数群体参加临床胰腺癌试验。发展计划 主任将实施旨在加强妇女、少数民族和残疾人参与的举措 SPORE临床试验并促进不同群体参与胰腺癌研究。 影响：拟议的工作将提高我们对胰腺癌生物学的理解，并将发现新的 这种难治性恶性肿瘤的早期检测、预防、成像和治疗策略。