Testing Homebased ExeRcise Strategies to Improve Exercise Participation and CardioVascular Health in UndersErved Minority Patients with Cancer Undergoing Chemotherapy, the THRIVE Study

THRIVE 研究测试家庭锻炼策略，以改善接受化疗的弱势少数癌症患者的运动参与和心血管健康

• 批准号: 10693238
• 负责人: CHRISTINA DIELI-CONWRIGHT
• 金额: $ 17.79万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-27 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693238
• 关键词: Address; Adherence; Adult; American; Behavior; Behavioral Mechanisms; Biological; Black race; Blood; Blood Glucose; Blood Pressure; Boston; Breast Cancer Treatment; C-Peptide; C-reactive protein; Cancer Center; Cancer Patient; Cancer Survivorship; Cardiotoxicity; Cardiovascular Physiology; Collaborations; Colorectal Cancer; Communities; Control Groups; Dana-Farber Cancer Institute; Data; Disadvantaged minority; Disparity; Enrollment; Ethnic Origin; European; European Organization for Research and Treatment of Cancer; Exercise; Fasting; Fatigue; Funding Mechanisms; Funding Opportunities; Hispanic; Hispanic Populations; Home; Insulin; Intervention; Knowledge; Life Style; Malignant Neoplasms; Malignant neoplasm of prostate; Massachusetts; Measures; Minority; Minority Groups; Mission; Obesity; Outcome; Overweight; Patient Outcomes Assessments; Patient Self-Report; Patients; Physical Function; Physical Performance; Physiological; Pittsburgh Sleep Quality Index; Population; Quality of life; Questionnaires; Randomized; Randomized, Controlled Trials; Recurrent disease; Reporting; Research; Resources; Risk Factors; Sampling; Science; Sleep; Socioeconomic Status; Testing; Treatment outcome; Underserved Population; Universities; Vulnerable Populations; Walking; actigraphy; black patient; cancer clinical trial; cancer health disparity; cardiorespiratory fitness; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; chemotherapy; comorbidity; comparison control; conditioning; cost effective; design; disorder risk; energy balance; ethnic minority population; exercise intervention; exercise training; experience; health disparity; high risk; improved; innovation; invention; lifestyle intervention; minority patient; mortality; novel; peripheral blood; post intervention; primary endpoint; psychologic; racial diversity; racial minority population; randomized trial; recruit; sedentary; underserved minority

SUMMARY/ABSTRACT Profound disparities exist in comorbid disease risk and lifestyle behaviors during and following chemotherapy in Hispanic and Black cancer patients, compared with European American counterparts. This includes declines in cardiorespiratory fitness paired with cardiotoxic effects, placing minority cancer patients at a higher risk for cardiovascular disease. Despite the beneficial effect of exercise training for cancer patients, rates of participation in clinical cancer trials are low among disadvantaged and racial/ethnic minority groups, possibly due to greater barriers and less access to exercise training. Therefore, the need for novel accessible and cost- effective home-based exercise intervention aimed at the Hispanic and Black communities to better understand physical activity interventions is crucial. We propose a pilot randomized trial to examine the effect of 16-week supervised and unsupervised exercise interventions in sedentary, overweight or obese Hispanic and Black cancer patients undergoing chemotherapy for the treatment of breast, colorectal, and prostate cancer. This proposal will address the following aims: 1) examine whether the inventions will increase daily minutes of exercise performed per week; 2) assess the effect of the inventions on cardiovascular risk factors; 3) determine the effect of the inventions on patient-reported outcomes and physical function. We hypothesize that both exercise groups will experience a significant increase in minutes of daily exercise per week, reductions in cardiovascular disease risk, improved quality of life, and physical function when compared to Controls. This study is innovative because a) we will conduct the study in high-need, understudied population, b) this is the first study to employ a novel and achievable intervention for a minority population receiving chemotherapy, c) integration of novel physiological variables for the intervention. Our proposal addresses the priority focus of this funding opportunity announcement through the design and implementation of an exercise intervention for an underserved, understudied, vulnerable population- Hispanic and Black patients receiving chemotherapy. The Co-PIs Drs. Dieli-Conwright (DFCI) and Yan (UMB) will bring together their expertise in exercise science, cancer survivorship, and cardiovascular physiology to successfully execute this project. This collaboration is uniquely made possible by the UMB-DF/HCC Partnership with the resources supported by the NCI CPACHE. Findings from this study will generate new knowledge about the effects of exercise intervention and provide guidance towards improving the quality and treatment tolerability in this population of underserved, vulnerable patients with cancer.

摘要/摘要 在化学疗法期间和之后，合并症的风险和生活方式行为存在很大的差异 在西班牙裔和黑色癌症患者中，与欧美同龄人相比。这包括下降 在心肺健康和心脏毒性作用中，使少数癌症患者面临更高的风险 心血管疾病。尽管运动训练对癌症患者产生了有益的作用，但 在不利的种族/种族少数群体中，参与临床癌症试验的参与很低，可能 由于更大的障碍和更少的运动训练。因此，需要新颖的可访问和成本 - 针对西班牙裔和黑人社区的有效家庭运动干预措施更好地了解 身体活动干预至关重要。我们提出了一项试验随机试验，以检查16周的效果 久坐，超重或肥胖的西班牙裔和黑色的监督和无监督的运动干预措施 接受化学疗法治疗乳腺癌，结直肠癌和前列腺癌的癌症患者。这 提案将解决以下目的：1）检查发明是否会增加每日纪要 每周进行运动； 2）评估发明对心血管危险因素的影响； 3）确定 发明对患者报告的结果和身体机能的影响。我们假设这两个 锻炼组每周的每天锻炼几分钟都会显着增加，减少 与对照组相比，心血管疾病的风险，改善的生活质量和身体机能。这 研究具有创新性，因为a）我们将在高需求，研究的人群中进行研究，b）这是 首次为接受化学疗法的少数族裔人群采用新颖且可实现的干预措施，c） 新型生理变量的整合进行干预。我们的提议解决了这一点的优先重点 通过设计和实施锻炼干预措施的资助机会公告 服务不足，研究不足，脆弱的人口 - 西班牙裔和黑人患者接受化疗。这 Co-Pis Drs。 Dieli-Conwright（DFCI）和Yan（UMB）将汇集他们在运动科学方面的专业知识， 癌症生存和心血管生理学成功执行该项目。这项合作是 UMB-DF/HCC合作伙伴关系与NCI CPACHE支持的资源使其成为独特的。 这项研究的发现将产生有关运动干预影响的新知识，并提供 为改善服务不足，弱势群体的质量和治疗耐受性的指导 癌症患者。