Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise Intervention

代谢综合征和乳腺癌：联合运动干预的效果

• 批准号: 8908890
• 负责人: CHRISTINA DIELI-CONWRIGHT
• 金额: $ 11.75万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8908890
• 关键词: Adverse effects; Aerobic; Award; Basic Science; Blood Pressure; Body Composition; Body Weight; Body mass index; Breast; Breast Cancer Treatment; Breast Cancer survivor; Breast Cancer survivorship; C-reactive protein; Cancer Survivorship; Cardiovascular Diseases; Cause of Death; Cities; Clinical Trials; Communities; Data; Descriptor; Development; Development Plans; Diabetes Mellitus; Diagnosis; Dietary Practices; Disease; Doctor of Philosophy; Early Diagnosis; Educational workshop; Endocrinology; Energy Metabolism; Environment; Epidemiologic Studies; Epidemiology; Exercise; Exercise Physiology; Faculty; Glucose; Glycosylated hemoglobin A; Goals; Health behavior; High Density Lipoprotein Cholesterol; Hyperglycemia; Hyperinsulinism; Hypertension; Incidence; Insulin; Insulin Resistance; Intervention; Intervention Trial; K-Series Research Career Programs; Lead; Life; Life Style; Lipids; Literature; Malignant Neoplasms; Measures; Medical; Medical Oncology; Medical center; Menopausal Status; Mentors; Metabolic; Metabolic syndrome; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Patients; Pattern; Physical Fitness; Physical activity; Physiology; Population; Population Sciences; Postmenopause; Premenopause; Randomized; Recording of previous events; Research; Research Design; Research Personnel; Research Proposals; Research Training; Resistance; Resources; Rest; Risk; Risk Factors; Scientific Advances and Accomplishments; Serum; Stratification; Survival Rate; Therapeutic Human Experimentation; Training; Translating; Treatment-Related Cancer; United States; Visceral; Weight Gain; Woman; Work; blood lipid; career; career development; demographics; design; disorder risk; experience; fitness; follow-up; improved; inflammatory marker; lifestyle factors; malignant breast neoplasm; member; muscle strength; prevent; skills; survivorship; waist circumference

DESCRIPTION (provided by applicant): This K07 Career Development Award is intended to assist me in achieving my long-term goal of becoming an independent and productive exercise interventionist for cancer populations, who is able to build and lead transdisciplinary research teams to better cancer survivorship outcomes. My immediate goals are to utilize this award to acquire in-depth training in fields related to breast cancer survivorship, 1) by advancing my skills in exercise physiology to encompass cancer populations, 2) by obtaining further training in the design and execution of clinical trials in cancer populations necessary to become an independent academic investigator, 3) by executing this proposal to develop my independent line of research, and 4) by developing epidemiologic research findings into translatable intervention trials while participating in educational workshops and seminars within the Departments of Population Sciences, Medical Oncology, and Endocrinology at the City of Hope. The training and research I am proposing will allow me to develop an integrated understanding of epidemiology, health behavior, endocrinology, medical oncology, and breast physiology to better develop expertise in breast cancer survivorship research. The City of Hope National Medical Center (COHNMC) offers a wide breadth of resources and career development opportunities that will be utilized in this award. The COHNMC has been at the forefront of medical and basic science research since it was established in 1918. The COHNMC provides a vast environment with a vibrant long-standing history of high-quality research, which include key faculty members that will serve on my mentoring committee: Leslie Bernstein, PhD (primary mentor), Joanne Mortimer, MD (co-mentor), and Fouad Kandeel, MD, PhD (co-mentor). Therefore, fundamental departments at the COHNMC are highly involved in my career development plan including the Departments of Population Sciences (Bernstein), Medical Oncology and Therapeutics Research (Mortimer), and Diabetes, Endocrinology and Metabolism (Kandeel). Each department and associated mentor will provide unique and supple training opportunities that will be critical for the development of my career and will establish the groundwork as I become an independent cancer researcher. Breast cancer is a prevalent disease which due to medical and scientific advances has a high survival rate. However, serious breast cancer treatment side effects such as weight gain persist during survivorship and present an increased risk of developing metabolic-related diseases including diabetes and cardiovascular disease. The goal of the proposed research is to investigate the effects of an exercise intervention on metabolic syndrome (MetS) risk factors in pre- and postmenopausal breast cancer survivors. The objective is to improve survivorship utilizing an exercise intervention to diminish elevated components of MetS among breast cancer survivors. The first specific aim is to determine whether a 16-week exercise intervention will improve components of metabolic syndrome by measuring changes in body composition, waist circumference, blood pressure, resting energy expenditure (REE), and serum levels of insulin, glucose, lipids, and inflammatory markers. I will randomly assign 100 premenopausal and postmenopausal breast cancer survivors into either the Control or Exercise group for 16 weeks. The exercise intervention will include three weekly supervised exercise sessions including aerobic and resistance exercise. The second specific aim is to determine whether a 16-week exercise intervention will improve physical fitness in breast cancer survivors soon after completion of cancer-related treatments by measuring cardiorespiratory fitness and muscle strength. Finally, the third specific aim is to determine whether breast cancer survivors can maintain positive benefits of an exercise intervention following a 12-week follow-up period by measuring changes in body composition, waist circumference, blood pressure, and serum levels of insulin, glucose, lipids, C-reactive protein, and HbA1c, cardiorespiratory fitness and muscle strength. Following completion of the proposed research aims, it is expected that a 16-week exercise intervention performed soon after the completion of treatment will improve 1) components of metabolic syndrome and 2) physical fitness and strength among breast cancer survivors. These results will have a significant impact on cancer survivorship and disease risk following diagnosis and treatment. Survival rates for breast cancer are relatively high translating to a need for healthy living to diminish risk of other diseases such as diabetes and cardiovascular disease.

描述（由申请人提供）：这项K07职业发展奖旨在帮助我实现我成为癌症人群的独立和生产性运动干预主义者的长期目标，他们能够建立和领导跨学科研究团队，以改善癌症生存成果。我的近期目标是利用该奖项来获得与乳腺癌幸存者有关的领域的深入培训，1）通过提高我在运动生理学方面的技能来涵盖癌症人群，2）2）通过在设计和执行临床试验中进一步培训，在癌症人群中进行临床试验的执行，使我成为独立的研究群体，通过执行我的独立研究，并通过执行我的独立研究，并4）4）4）4）干预试验在参加人口科学，医学肿瘤学和希望之城的教育研讨会和研讨会的同时。我提出的培训和研究将使我能够对流行病学，健康行为，内分泌学，医学肿瘤学和乳房生理学建立综合的了解，以更好地发展乳腺癌生存研究方面的专业知识。希望之城国家医疗中心（COHNMC）提供了广泛的资源和职业发展机会，这些机会将在该奖项中使用。自1918年成立以来，CoHNMC一直处于医学和基础科学研究的最前沿。Cohnmc提供了一个庞大的环境，具有充满活力的高质量研究历史，其中包括将在我的指导委员会中任职的重要教师：Leslie Bernstein，Ph.Bernstein，Phd DD（PRIMICAR），Joanne Mortimer，Mdimer，Mdeel，Mdore，Mdord（Mdord），MD） （联盟）。因此，CohnMC的基本部门高度参与了我的职业发展计划，包括人口科学部（伯恩斯坦），医学肿瘤学和治疗学研究（Mortimer）以及糖尿病，内分泌学和代谢（Kandeel）。每个部门和相关的导师将提供独特而柔和的培训机会，这对于我职业生涯的发展至关重要，并在我成为独立的癌症研究员时会建立基础。乳腺癌是一种普遍的疾病，由于医学和科学进步，其存活率很高。然而，严重的乳腺癌治疗副作用，例如在生存期间体重增加持续存在，并提出了患有代谢相关疾病在内的风险增加，包括糖尿病和心血管疾病。拟议的研究的目的是研究运动干预对绝经前和绝经后乳腺癌幸存者中代谢综合征（METS）危险因素的影响。目的是利用运动干预措施来改善生存，以减少乳腺癌幸存者中Mets的成分升高。第一个具体目的是确定16周的运动干预是否会通过测量身体成分，腰围，血压，静息能量消耗（REE）以及胰岛素，葡萄糖，脂质和炎症标记的血清水平来改善代谢综合征的组成部分。我将随机将100个绝经前和绝经后乳腺癌幸存者分为对照组或运动组16周。运动干预将包括每周进行三场监督运动，包括有氧和抵抗运动。第二个具体目的是确定16周的运动干预措施是否通过测量心肺健康和肌肉力量完成与癌症相关治疗后不久是否会改善乳腺癌幸存者的身体健康。最后，第三个具体的目的是确定乳腺癌幸存者是否可以通过衡量身体成分，腰围，血压，血压以及血清胰岛素，葡萄糖，脂质，脂质，C-反应性蛋白质和HBA1C，Cardiorpiration Pripitiration Priptiration Fitnity和肌肉的强度来确定乳腺癌幸存者是否可以维持运动干预的积极益处。 拟议的研究目的完成后，预计在治疗完成后不久进行了16周的运动干预措施将改善1）代谢综合征的组成部分，以及2）乳腺癌幸存者的身体健康和力量。这些结果将对诊断和治疗后的癌症生存和疾病风险产生重大影响。乳腺癌的存活率相对较高，转化为健康生活的需求，以减少其他疾病（例如糖尿病和心血管疾病）的风险。

项目成果

Reducing the Risk of Breast Cancer Recurrence: an Evaluation of the Effects and Mechanisms of Diet and Exercise.

• DOI: 10.1007/s12609-016-0218-3
• 发表时间: 2016
• 期刊: CURRENT BREAST CANCER REPORTS
• 影响因子: 0.9
• 作者: Dieli-Conwright, Christina M;Lee, Kyuwan;Kiwata, Jacqueline L
• 通讯作者: Kiwata, Jacqueline L

Metabolic syndrome and breast cancer survivors: a follow-up analysis after completion of chemotherapy.

• DOI: 10.1186/s13098-022-00807-y
• 发表时间: 2022-03-03
• 期刊: Diabetology & metabolic syndrome
• 影响因子: 4.8
• 作者: Dieli-Conwright CM;Wong L;Waliany S;Mortimer JE
• 通讯作者: Mortimer JE

Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods.

• DOI: 10.1186/1471-2407-14-238
• 发表时间: 2014-04-03
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Dieli-Conwright CM;Mortimer JE;Schroeder ET;Courneya K;Demark-Wahnefried W;Buchanan TA;Tripathy D;Bernstein L
• 通讯作者: Bernstein L