Brain and behavior correlates of prenatal cannabis exposure

产前大麻暴露的大脑和行为相关性

基本信息

批准号：
10734717
负责人：
STEPHEN R DAGER
金额：
$ 69.61万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734717
关键词：
ATOD Affect Age Age Months Alcohols Amygdaloid structure Animal Experimentation Animals Antiemetics Anxiety Attention Behavior Behavioral Binding Biological Assay Birth Birth Weight Brain Brain imaging Brain region COVID-19 pandemic Cannabidiol Cannabinoids Cannabis Cell Adhesion Molecules Cerebellum Complementary and alternative medicine Conceptions Conscious Consumption Data Development Diffusion Magnetic Resonance Imaging Disease Dopamine D2 Receptor Dose Early Diagnosis Educational Status Endocannabinoids Enrollment Evaluation Exclusion Criteria Exhibits Female First Pregnancy Trimester Frequencies Functional Magnetic Resonance Imaging Goals Growth Head circumference Health Health Benefit Human Illicit Drugs Infant Influentials Label Legal Legal Status Length Magnetic Resonance Imaging Measures Medicine Memory Modernization Monitor Mothers Multimodal Imaging Nausea and Vomiting Neonatal Neurodevelopmental Disorder Neuropsychology Newborn Infant Odors Outcome Outcomes Research Pacific Northwest Participant Pathway interactions Patient Self-Report Perception Persons Pharmacologic Substance Placenta Population Pregnancy Pregnant Women Product Labeling Property Prospective Studies Protocols documentation Psychotropic Drugs Recreation Regulation Reporting Research Risk Second Pregnancy Trimester Sex Differences Signal Transduction Sleep Stimulus Structure System Testing Tetrahydrocannabinol Third Pregnancy Trimester Time Tobacco Update Urine Visit Washington Woman Work adverse outcome autism spectrum disorder behavior measurement behavioral outcome brain dysfunction cannabinoid receptor density design drug of abuse experience fetal marijuana exposure follow up assessment frontal lobe imaging study in utero indexing infancy infant outcome innovation male marijuana legalization marijuana use marijuana use in pregnancy marijuana user maternal marijuana use motor behavior myelination neural neurobehavior neurobehavioral neurodevelopment pain reduction polysubstance use pregnant prenatal prenatal exposure programs prospective receptor density recruit response reward processing symptom management white matter

项目摘要

Cannabis use during pregnancy has increased substantially, in conjunction with widespread decriminalization/legalization, changing public perceptions about harm, and evidence of cannabis's antiemetic properties. Prior outcomes research on prenatal cannabis exposure is narrow in scope, as these older studies included research participants with polysubstance use (e.g., tobacco, alcohol, illicit drugs). In addition, prior research also likely underestimated potential risks specific to cannabis use during pregnancy because modern strains are 10x more potent than they were 40 years ago. We propose to study neurodevelopment in infants exposed in utero to cannabis using state-of-the-art MRI and behavioral measures. Maternal cannabis use will be measured prospectively using weekly reports validated with labels and urine-based assays. By focusing on infancy, we aim to characterize cannabis-induced brain changes at a time when environmental effects are minimized and are less influential than at older. In addition, we will test the hypothesis that prenatal cannabis exposure is more detrimental to male than females. To test our hypotheses, we will recruit 200 pregnant people (where the mother uses cannabis, but not other drugs, tobacco, or alcohol) and 170 pregnant control participants matched on education level. Infants will receive a neonatal neurobehavioral exam and multi-modal imaging (functional magnetic resonance imaging, diffusion tensor imaging, and structural MRI) under natural sleep at 2-4 weeks-of-age and extensive neuropsychological follow-up assessments at 6 and 18 months. This program of research aims to clarify potential health risks, enabling pregnant people to make better-informed choices surrounding cannabis use during pregnancy.

怀孕期间大麻的使用大幅增加，同时广泛传播非刑事化/合法化、改变公众对危害的看法以及大麻止吐的证据特性。先前关于产前大麻暴露的结果研究范围狭窄，因为这些较旧的研究包括使用多种物质（例如烟草、酒精、非法药物）的研究参与者。另外，之前研究还可能低估了怀孕期间使用大麻的潜在风险，因为现代菌株的效力比 40 年前强 10 倍。我们建议研究婴儿的神经发育使用最先进的 MRI 和行为测量在子宫内暴露于大麻。产妇吸食大麻会使用经标签和尿液检测验证的每周报告进行前瞻性测量。通过专注于在婴儿期，我们的目标是在环境影响严重的时候描述大麻引起的大脑变化的特征与年长时相比，其影响力已最小化且较小。此外，我们将检验产前大麻的假设暴露对男性的危害比女性更大。为了检验我们的假设，我们将招募 200 名孕妇人（母亲使用大麻，但不使用其他药物、烟草或酒精）和 170 怀孕对照参与者的教育水平相匹配。婴儿将接受新生儿神经行为检查和多模式检查自然条件下的成像（功能磁共振成像、扩散张量成像、结构磁共振成像） 2-4 周龄时进行睡眠，并在 6 个月和 18 个月时进行广泛的神经心理学随访评估。这该研究计划旨在澄清潜在的健康风险，使孕妇能够更好地了解情况关于怀孕期间使用大麻的选择。