CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM

浓缩气溶胶输送和量化系统

• 批准号: 6404745
• 负责人: Donovan B Yeates
• 金额: $ 43.79万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6404745
• 关键词: aerosols; biomedical equipment development; drug delivery systems; fluoresceins; inhalation drug administration; laboratory rat; measurement; physical property; plethysmography; spectrometry

DESCRIPTION (provided by applicant): BioTechPlex Corporation proposes to develop an improved aerosol delivery system. The proposed system, Concentrated Aerosol Delivery and Quantization System, CADAQS, will fulfill the need to acutely deliver high particle number concentrations of aerosols to the respiratory tract of small animals (rats, young rabbits, and guinea pigs: wt < 1000 g), while enabling the quantization of their deposition in the lungs. The CADAQS consists of 3 subsystems. A) A two stage aerosol concentrator, TSAC, concentrates aerosols of 1-5 pm AMMD. B) A Small Animal Aerosol Delivery System, SAADS, a zero-dead space nose cone incorporated into a whole body plethysmograph complete with sensors and data acquisition and analysis system. C) A Quantitative Aerosol Deposition System, QADS, utilizes a pair of 4 pixelated CdZnTi detectors with integrated ASIC placed laterally to each lung. In Phase I, we successfully constructed the TSAC prototype. In this Phase II project, we will construct the complete CADQAS system so that prototypes of commercial systems can be generated. The system will be tested using rats. The TSAC, the SAADS, and the QADS are designed to be sold as stand-alone devices as well as components of CADAQS. Such a system is not available commercially. This system will be used for environmental and occupational toxicology. It will also greatly facilitate the processes of drug discovery, toxicology and pharmacology through the delivery of drugs to the respiratory tract for both local and systemic drug delivery. PROPOSED COMMERCIAL APPLICATION: This system is designed to deliver concentrated aerosols to small animals while enabling the quantization of aerosols deposited in the lungs. This system can also act as a forerunner of the development of technologies for measuring cardiopulmonary function and aerosol delivery to premature infants.

描述（由申请人提供）：Biotechplex Corporation建议开发改进的气溶胶输送系统。提出的系统集中 CADAQS的气溶胶输送和量化系统将满足需要 急性向高颗粒数浓度的气溶胶浓度 小动物的呼吸道（大鼠，幼犬和豚鼠：wt < 1000 g），同时可以量化其在肺中的沉积。这 CADAQ由3个子系统组成。 a）两级气溶胶浓缩器TSAC， 浓缩气溶胶为1-5 pm ammd。 b）一个小动物气溶胶输送 系统，saads，零死的空口锥体纳入整个身体 配备传感器以及数据采集和分析系统。 c）定量气溶胶沉积系统，QADS使用了一对4 像素化的CDZNTI探测器具有横向放置在每个肺部的ASIC集成。 在第一阶段，我们成功构建了TSAC原型。在这个阶段II 项目，我们将构建完整的CADQAS系统，以便原型 可以生成商业系统。该系统将使用大鼠进行测试。这 TSAC，SAADS和QADS被设计为以独立设备的形式出售 以及CADAQS的组件。这样的系统在商业上不可用。这 系统将用于环境和职业毒理学。它也会 极大地促进了药物发现，毒理学和药理学的过程 通过向局部和 全身药物输送。 拟议的商业应用： 该系统旨在将浓缩气溶胶传递给小动物，同时可以量化沉积在肺部的气溶胶。该系统还可以充当用于测量心肺功能和向早产儿的气溶胶递送的技术开发的先驱。