Identification of viral exposure signatures for early detection of liver cancer

鉴定病毒暴露特征以早期发现肝癌

• 批准号: 10703084
• 负责人: Xin Wei Wang
• 金额: $ 18.19万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703084
• 关键词: Affect; CCR; Chronic Disease; Communities; Data Analyses; Development; Emerging Technologies; Epitopes; Extramural Activities; Health; Human; Human Resources; Immunity; Individual; Infection; Leadership; Malignant Neoplasms; Methodology; Molecular; Pathogenesis; Pathogenicity; Procedures; Research Personnel; Screening for Hepatocellular Cancer; Serology; Services; Technology; Viral; Virus; data acquisition; data pipeline; human virome; response

Viruses are known to affect human health by altering host immunity and leaving a unique molecular footprint during infection, which makes the interplay between the human virome and the host a crucial molecular window reflecting the pathogenesis of human chronic diseases including cancer. The CCR Human Virome Core has successfully developed and implemented a standard operating procedure, including a pipeline from data acquisition to data analysis, for an emerging technology called VirScan. This technology allows comprehensive profiling of individuals' serological responses to all known human viruses including over 200 species and 1,000 strains of human pathogenic and non-pathogenic viruses at the epitope level. Currently, efforts are aimed at establishing the core, including hiring personnel.

众所周知，病毒通过改变宿主免疫力并在感染过程中留下独特的分子足迹来影响人类健康，这使得人类病毒组与宿主之间的相互作用成为反映包括癌症在内的人类慢性疾病发病机制的关键分子窗口。 CCR 人类病毒组核心已成功开发并实施了标准操作程序，包括从数据采集到数据分析的管道，用于名为 VirScan 的新兴技术。该技术可以在表位水平上全面分析个体对所有已知人类病毒的血清学反应，包括 200 多个物种和 1,000 株人类致病性和非致病性病毒。目前，主要工作是建立核心，包括招聘人员。