Near-infrared spectroscopy and electroencephalography to assess cortical activation during motor tasks in infants and toddlers with or at high-risk for Cerebral Palsy and Autism Spectrum Disorder comp

近红外光谱和脑电图用于评估患有脑瘫和自闭症谱系障碍或具有高风险的婴儿和幼儿运动任务期间的皮质激活

• 批准号: 10691087
• 负责人: DIANE L. DAMIANO
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10691087
• 关键词: 1 year old; 3 year old; 5 year old; Adult; Age; Area; Biomechanics; Blood flow; Body Weight; Brain; Cerebral Palsy; Child; Childhood; Clinical; Control Groups; Cross-Sectional Studies; Data; Data Analyses; Data Collection; Development; Devices; Electroencephalography; Electromyography; Enrollment; Force of Gravity; Friction; Future; Hand; Image; Infant; Intervention; Intervention Trial; Investigation; Kinetics; Knowledge; Laboratories; Leg; Life; Limb structure; Literature; Location; Measures; Motion; Motor; Motor Skills; Movement; Near-Infrared Spectroscopy; Observational Study; Outcome Measure; Participant; Pattern; Performance; Population Group; Protocols documentation; Rehabilitation therapy; Reporting; Specific qualifier value; Surface; Technology; Time; Toddler; Toy; Walkers; Weight-Bearing state; age group; autism spectrum disorder; coronavirus disease; design; disability; grasp; high risk; infancy; kinematics; longitudinal analysis; mobility aid; motor control; nervous system disorder; neural; portability; primary outcome; response; secondary outcome; study population; treadmill; vaccine access; wearable sensor technology

This project was severely impacted by COVID. We had collected data on multiple infants from 2018-2020, but we have only recently restarted data collection this summer now that COVID vaccines are available for infants. Precis: Portable neural imaging during functional tasks is now possible utilizing non-invasive near-infrared spectroscopy (NIRS) which identifies areas of brain activity by measuring blood flow dynamics and electroencephalography (EEG) which measures electrical activity on the cortical surface. Use of these technologies for studying movement is rapidly increasing; however, investigations in children and those with neurological disorders such as cerebral palsy (CP) or autism spectrum disorder (ASD) are still in the early stages with few reports in the literature. The objectives of this protocol are to systematically compare cortical activation patterns during specified sensorimotor tasks in infants and young children with typical development (TD) to those with and at high-risk for CP and ASD, examine developmental changes in brain activation patterns that underlie the emergence of early functional or dysfunctional motor control and explore the neural and biomechanical effects of different devices that make movement easier for infants and toddlers with CP and ASD. The results are expected to increase knowledge of brain activation patterns across tasks in groups with and without neurological disorders and to suggest potential mechanisms or strategies for future clinical intervention trials. Study population The group with CP will consist of up to 100 children ages 3 months up to 5 years of age. The group with ASD (including all infants less than 3 years of age who are identified as being at high-risk for ASD) will consist of up to 100 children ages 3 months up to 5 years of age. The control group will consist of up to 100 children with TD within the same age range. Design This is an observational study that will include cross-sectional and longitudinal data collection. NIRS and/or EEG responses, and kinematic and/or kinetic, force plate, wearable sensors and/or electromyography (EMG) recordings will be collected on all participants during the performance of self-initiated motor tasks. Additionally, we will evaluate brain and motor responses to devices that aim to make movement easier for infants and children who may have difficulty initiating or performing these movements without assistance. Outcome measures Primary outcomes are the magnitude, extent and location of brain activity recorded by NIRS and/or EEG within tasks across subject groups. We will also quantify changes in brain activation across ages (cross-sectional) and time (longitudinal). Secondary outcomes may include motion , force plate, wearable sensors and EMG data to help interpret task and group differences and measures of motor abilities. The same outcome measures will be compared across ages to examine the development of cortical activation patterns and motor abilities and how these change over time and across groups with and without neurological disorders.

该项目受到Covid的严重影响。从2018 - 2020年开始，我们已经收集了有关多个婴儿的数据，但是直到今年夏天我们才重新启动了数据收集，因为可供婴儿使用Covid疫苗。 精确：功能任务期间的便携式神经成像现在可以利用非侵入性近红外光谱（NIR）通过测量血流动力学和脑电图（EEG）来测量在皮质表面上的电活动来识别大脑活动的区域。使用这些技术来研究运动正在迅速增加。但是，对儿童和神经系统疾病的人进行的调查，例如脑瘫（CP）或自闭症谱系障碍（ASD）仍处于早期阶段，文献中很少有报道。该方案的目标是在婴儿和具有典型发育的婴儿和幼儿指定的感觉运动任务期间系统地比较皮质激活模式，与CP和ASD高风险和ASD的患者相比，检查脑激活模式的发展变化，这些变化是基于大脑激活模式的变化。早期功能或功能失调的运动控制的出现，并探索不同设备的神经和生物力学效应，使患有CP和ASD的婴儿和幼儿更容易运动。预计该结果将增加对有或没有神经系统疾病的组组的大脑激活模式的了解，并提出对未来临床干预试验的潜在机制或策略。研究人群CP的组将包括最多100名3个月的儿童，最高5岁。拥有ASD的小组（包括所有被确定为高风险ASD的婴儿）将包括多达100名3个月的儿童，最高5岁。 对照组最多将包括100名TD儿童在同一年龄范围内。设计这是一项观察性研究，其中包括横截面和纵向数据收集。 NIR和/或EEG响应，以及运动和/或动力学，力板，可穿戴传感器和/或肌电图（EMG）记录，在执行自我激发的运动任务期间，将收集所有参与者的记录。此外，我们将评估对设备的大脑和运动反应，旨在使可能在没有帮助的情况下启动或执行这些运动的婴儿和儿童更容易运动。结果指标的主要结果是NIRS和/或EEG在跨受试者组中记录的大脑活动的大小，程度和位置。我们还将量化跨年龄（横截面）和时间（纵向）的大脑激活变化。次要结果可能包括运动，力板，可穿戴传感器和EMG数据，以帮助解释任务以及小组差异和运动能力的度量。将比较各个年龄段的相同结果指标，以检查皮质激活模式和运动能力的发展，以及它们如何随着时间和神经系统疾病的群体的变化而变化。