Oxidative Stress, Hormones and Women s Health

氧化应激、激素和女性健康

• 批准号: 10690343
• 负责人: Neil Perkins
• 金额: $ 0.35万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10690343
• 关键词: Address; Affect; Age; Alcohol consumption; Anovulation; Attention; Behavioral; Biological; Biological Markers; Chronic Disease; Data; Diet; Dietary Factors; Environmental Epidemiology; Estrogens; Exercise; Failure; Functional disorder; Goals; Gonadal Steroid Hormones; Health; Hormonal; Hormones; Impairment; Influentials; Intake; Life Style; Longitudinal cohort study; Luteal Phase; Menstrual cycle; Menstruation; Metabolism; Oxidative Stress; Paper; Periodicity; Physiological; Premenopause; Premenstrual syndrome; Public Health; Publishing; Research; Role; Symptoms; Variant; Vegetable Proteins; Vitamin D; Woman; Women' s Health; aged; cardiometabolism; cigarette smoking; design; disorder risk; follow-up; high risk; insight; interest; nutritional epidemiology; prospective; reproductive; reproductive hormone; social epidemiology

The BioCycle Study was a prospective longitudinal cohort study comprising 259 women aged 18 to 44 years (98% follow-up rate) followed for two menstrual cycles (2005-2007). The study was designed to better understand menstrual cycle function and the intricate relationships between reproductive hormone levels and oxidative stress. Since completion of the study, much progress has been made in the analysis of the BioCycle Study data. To date, over 80 papers have been published. The BioCycle Study has contributed substantially to the fields of nutritional, environmental, and social epidemiology, offering valuable insights into various factors associated with premenopausal womens reproductive and cardio-metabolic health. In particular, several physiologic and behavioral factors were recently evaluated with regard to their associations with reproductive hormones and menstrual cyclicity, as well as ovulatory function. Dr. Mumfords team found that markers of vitamin D metabolism (PMID: 33864070), and oxidative stress but not antioxidants (PMCID: PMC7851915), were associated with select symptoms of premenstrual syndrome. Further, low intake of vegetable protein (PMID: 33735390) was associated with hormone levels and a higher risk of anovulation, highlighting the potential role of dietary factors to influence ovulatory function in reproductive-aged women. Overall, this body of work has been influential in describing not only the short-term impact of diet and lifestyle on hormonal function and markers of menstrual cycle dysfunction (e.g., anovulation, luteal phase deficiency, and abnormal menses) but their potential long-term impact on chronic disease risk. The team intends to build upon its current findings from the BioCycle Study to fill critical research gaps in its quest to answer important public health questions for women of reproductive age.

BioCycle 研究是一项前瞻性纵向队列研究，纳入了 259 名 18 至 44 岁的女性（随访率 98%），随访了两个月经周期（2005-2007 年）。该研究旨在更好地了解月经周期功能以及生殖激素水平与氧化应激之间的复杂关系。自研究完成以来，生物循环研究数据的分析取得了很大进展。迄今为止，已发表论文80余篇。生物循环研究对营养、环境和社会流行病学领域做出了重大贡献，为与绝经前女性生殖和心脏代谢健康相关的各种因素提供了宝贵的见解。特别是，最近评估了几种生理和行为因素与生殖激素、月经周期以及排卵功能的关系。 Mumfords 博士团队发现，维生素 D 代谢标记物 (PMID: 33864070) 和氧化应激标记物 (PMCID: PMC7851915) 与经前综合症的特定症状相关，但与抗氧化剂无关 (PMCID: PMC7851915)。此外，植物蛋白摄入量低（PMID：33735390）与激素水平和较高的不排卵风险相关，这凸显了饮食因素对育龄女性排卵功能的潜在影响。 总体而言，这项工作不仅在描述饮食和生活方式对荷尔蒙功能和月经周期功能障碍标志物（例如无排卵、黄体期缺乏和月经异常）的短期影响方面具有影响力，而且在描述其潜在的长期影响方面也具有影响力。对慢性病风险的影响。该团队打算以生物循环研究的当前发现为基础，填补关键的研究空白，以解答育龄妇女的重要公共卫生问题。