Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

杏仁核介导的人类记忆增强机制

• 批准号: 10700939
• 负责人: Jon Timothy Willie
• 金额: $ 31.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700939
• 关键词: Affect; Amygdaloid structure; Anatomy; Anterior; Arousal; Authorization documentation; Basic Science; Complex; Coupling; Disease; Electric Stimulation; Electrodes; Electrophysiology (science); Emotional; Event; Evoked Potentials; Frequencies; Hippocampus; Human; Image; Individual; Investigation; Location; Longevity; Maps; Medial; Mediating; Memory; Memory Disorders; Mental Health; Movement; Neurons; Outcome; Output; Patients; Performance; Phase; Physiologic pulse; Post-Traumatic Stress Disorders; Process; Rattus; Regional Anatomy; Research; Role; Structure; Temporal Lobe; Testing; Time; Traumatic Brain Injury; authority; awake; design; emotional experience; emotional functioning; experience; improved; long term memory; member; memory consolidation; memory process; memory recognition; neural; neural network; neuromechanism; neurosurgery; novel therapeutics; response; spatial memory

PROJECT SUMMARY/ABSTRACT Direct electrical stimulation (DES) of the basolateral complex of the amygdala (BLA) can improve declarative memory, reflecting the role of the BLA in modulating memory processes in medial temporal lobe (MTL) regions as a function of emotional arousal. Thus, DES can reveal mechanisms of BLA-mediated memory enhancement relevant to human mental health and disease. DES of the BLA can be used to interrogate the function of memory circuits, especially how neuronal oscillations in the MTL support declarative memory. First, BLA is hypothesized to wield the capacity to prioritize long-term retention of information initially encountered adjacent in time. Second, the BLA preferentially projects to anterior MTL regions and thus is hypothesized to preferentially modulate memory processes in those anatomic regions, processes thought to support memory for non-spatial items more so than memory for spatial locations. Third, although emotional arousal, amygdala activity, MTL activity, and memory performance are typically correlated, we hypothesize that DES will reveal that BLA outputs to other MTL regions cause improved memory performance by directly eliciting pro-memory oscillatory states in those networks. The expected outcomes represent a significant advancement for the basic science of normal memory function and significant movement towards novel therapeutics designed to emulate endogenous mechanisms of memory enhancement.

项目摘要/摘要 杏仁核基底外侧复合物（BLA）的直接电刺激（DES）可以改善 声明性记忆，反映BLA在调节内侧颞叶中的记忆过程中的作用 （MTL）区域是情绪唤醒的函数。因此，DES可以揭示BLA介导的记忆的机制 与人类心理健康和疾病有关的增强。 BLA的DES可用于审问 内存电路的功能，尤其是MTL中的神经元振荡如何支持声明记忆。第一的， 假设BLA是为了确定最初遇到的信息的长期保留的能力 邻近时间。其次，BLA优先投射到前MTL区域，因此假设 优先调节这些解剖区域中的内存过程，被认为支持的过程 非空间项目比空间位置的内存更重要。第三，虽然情绪激动，但杏仁核 活动，MTL活动和记忆性能通常是相关的，我们假设DES将揭示 BLA输出到其他MTL区域通过直接引发亲信会导致记忆性能提高 这些网络中的振荡状态。预期的结果代表了基本的重大进步 正常记忆功能的科学和旨在仿真的新型治疗剂的重要运动 记忆增强的内源机制。