The Impact of Zinc Intake on Nutritional Status and Brain Development Among Preterm Infants

锌摄入量对早产儿营养状况和大脑发育的影响

• 批准号: 10700127
• 负责人: Katherine Bell
• 金额: $ 16.6万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700127
• 关键词: 2 year old; Address; Age; Area; Biochemistry; Birth; Body Composition; Brain; Child; Childhood; Clinical; Cognitive; Confounding Factors (Epidemiology); Data; Data Correlations; Degree program; Deposition; Development; Development Plans; Diet; Dietary Intervention; Dietary intake; Disease; Ensure; Environment; Exhibits; Failure; Fatty acid glycerol esters; Foundations; Funding; Future; Goals; Growth; Growth and Development function; Health; Hospitalization; Hospitals; Human Milk; Impairment; Infant; Institution; Intake; Interruption; Intervention; Knowledge; Link; Longitudinal cohort; Macronutrients Nutrition; Malnutrition; Measurement; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Micronutrients; Milk; Monitor; Morbidity - disease rate; Motor; Neonatal; Neonatal Intensive Care Units; Neurocognitive; Neurodevelopmental Impairment; Nutrient; Nutrition Assessment; Nutritional; Nutritional Science; Nutritional Support; Nutritional status; Outcome; Physicians; Play; Premature Birth; Premature Infant; Preparation; Proteins; Proxy; Recommendation; Research; Research Personnel; Resources; Role; Sampling; Schools; Scientist; Statistical Data Interpretation; Supplementation; Testing; Thinness; Training; United States National Institutes of Health; Weight Gain; Woman; Work; Zinc; Zinc deficiency; brain magnetic resonance imaging; career; career development; critical period; design; executive function; experience; extreme prematurity; fortification; high risk infant; improved; infancy; infant nutrition; innovation; medical schools; meetings; neonatal period; neurodevelopment; new technology; novel; nutrition; organ growth; patient oriented research; rapid growth; repository; skills; success; sustained attention; timeline; training opportunity; white matter

ABSTRACT This K23 proposal describes a five-year research and training plan to facilitate Dr. Katherine Bell’s transition into an independent physician-scientist in the field of neonatal nutrition. Dr. Bell is a neonatologist with a strong foundation in patient-oriented research. Nutrient deficits occurring during the neonatal intensive care unit (NICU) hospitalization impair preterm infants’ growth and maturation during a critical period for development of the body and brain, adversely impacting long-term neurodevelopmental outcomes. The essential micronutrient zinc is crucial for infant growth and brain development, but the optimal zinc intake for preterm infants is unknown and current fortification strategies may be insufficient. Accurate assessment of nutritional status in preterm infants is facilitated by distinguishing lean mass—which reflects organ growth and maturation—from fat. The goal of this proposal is to determine the association between zinc intake in the NICU and lean mass accrual (as a marker of nutritional status) and to evaluate the clinical impact of variabilities in zinc intake on concurrent brain development and later neurodevelopmental outcomes. The hypothesis that greater zinc intake results in greater lean mass accrual, improved brain growth and maturation, and improved neurodevelopment will be tested through 3 specific aims: 1) Determine the association of zinc intake in the NICU with lean mass at term equivalent age. 2) Determine the association between zinc intake in the NICU and brain growth and maturation. 3) Determine the impact of neonatal zinc intake on neurodevelopmental outcomes at 2 years. This research is significant for the field of neonatal nutrition, as knowledge gained from this study will help determine optimal zinc intake for preterm infants and inform the design of nutritional strategies to ensure adequate micronutrient provision to all preterm infants. Dr. Bell’s mentoring team—Dr. Belfort (primary mentor) and Dr. Duggan (co-mentor)—provide complementary expertise in preterm infant nutrition and micronutrient requirements in children, respectively. Dr. Bell will also receive mentorship from distinguished scientists with expertise in key areas related to this work, including micronutrient biochemistry, breastmilk composition, neurodevelopmental assessment in childhood, and the developmental origins of disease. The training opportunities and resources at Brigham and Women’s Hospital, Tufts Friedman School of Nutrition Science, and Harvard Medical School are an ideal environment for the candidate’s career development. The candidate’s institution is strongly committed to her success. Dr. Bell’s detailed career development plan includes mentored research, didactic coursework including a formal degree in nutrition science, seminars, and presentations at scientific meetings. She presents a timeline for completion of the research aims and preparation of a future R01 application. The knowledge and training gained from this K23 award will enable Dr. Bell to develop the skills and expertise required to launch an independent research career focused on designing micronutrient interventions to optimize growth and long-term health outcomes for preterm infants.

抽象的 该K23提案描述了一项为期五年的研究和培训计划，以促进凯瑟琳·贝尔博士的过渡 进入新生儿营养领域的独立医师科学家。 在新生儿护理部 （NICU）住院损害早产儿的成长和生产率 身体和大脑会影响长期神经发育结果 锌对于婴儿的生长和大脑发育至关重要，但是最佳的锌摄入量是 未知和当前的防御力策略可能是对营养状况的准确评估 早产儿通过区分瘦质量（反映器官的生长和成熟）来促进。 脂肪。 应计（作为营养状况的标记），并评估锌摄入量变异性的临床影响 并发的大脑发育和后来的神经发育结果。 导致更大的瘦质量应计，改善大脑和成熟以及不良发育 将通过3个特定目的进行测试：1）确定NICU中锌和瘦质量的锌摄入量的关联 在等效年龄2）确定NICU与大脑生长的锌摄入量和 成熟。 研究对新生儿营养领域很重要，因为这项研究所获得的知识会地狱 确定早产的最佳锌摄入量，以确保营养策略的设计 为所有早产儿提供足够的微量营养素。 Duggan博士（Co-Incertor） - 早产儿营养和微量营养素的汇编专业知识 在儿童的要求中，贝尔博士将获得杰出科学家的指导 与这项工作相关的关键领域的专业知识，倾斜的微量营养素双授予，Breatmilk组成， 童年的神经发育评估和疾病的发育起源。 Brigham and妇女医院的机会和资源，塔夫茨弗里德曼营养科学学院， 哈佛医学院是候选人的理想环境 机构强烈致力于她的成功。 研究，教学课程，包括营养科学的正式学位，研讨会和天堂 科学会议。 R01申请。 启动专注于设计微量营养素的独立研究职业所需的技能和专业知识 为早产儿提供优化增长和长期健康结果的干预措施。