Core B: Neuroimaging Core

核心 B：神经影像核心

基本信息

批准号：
10684077
负责人：
Abhijit J Chaudhari
金额：
$ 27.2万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684077
关键词：
Acute Affect Brain Brain imaging Budgets Chronic Collaborations Communities Data Data Analyses Dedications Derivation procedure Development Dimensions Disease Doctor of Philosophy Emerging Technologies Ensure Equipment Fluorescence Functional Imaging Functional disorder Future Genomics Goals Grant Human IACUC Image Image Analysis Imaging Device Imaging technology Intoxication Lead Machine Learning Magnetic Resonance Imaging Manuscripts Measures Medical Imaging Methods Microscopic Military Personnel Mission Modality Modernization Molecular Monitor Neurologic Organophosphates Pharmacology Positron-Emission Tomography Preparation Protocols documentation Radiology Specialty Reproducibility Research Research Personnel Resources Scientist Surrogate Endpoint Technology Therapeutic Therapeutic Intervention Tissue imaging Tracer Training Translating Validation X-Ray Computed Tomography analysis pipeline anatomic imaging animal imaging cellular imaging data acquisition design education research experience experimental study fluorescence imaging human imaging image processing imaging Segmentation imaging biomarker imaging modality imaging probe imaging science imaging study improved in vivo in vivo imaging kinetic model molecular imaging multimodality neuroimaging neuroimaging marker neuropathology neurotoxicology novel optical imaging professor quantitative imaging radiotracer response structural imaging success targeted imaging therapeutically effective tool toxic organophosphate insecticide exposure virtual

Acute Affect Brain Brain imaging Budgets Chronic Collaborations Communities Data Data Analyses Dedications Derivation procedure Development Dimensions Disease Doctor of Philosophy Emerging Technologies Ensure Equipment Fluorescence Functional Imaging Functional disorder Future Genomics Goals Grant Human IACUC Image Image Analysis Imaging Device Imaging technology Intoxication Lead Machine Learning Magnetic Resonance Imaging Manuscripts Measures Medical Imaging Methods Microscopic Military Personnel Mission Modality Modernization Molecular Monitor Neurologic Organophosphates Pharmacology Positron-Emission Tomography Preparation Protocols documentation Radiology Specialty Reproducibility Research Research Personnel Resources Scientist Surrogate Endpoint Technology Therapeutic Therapeutic Intervention Tissue imaging Tracer Training Translating Validation X-Ray Computed Tomography analysis pipeline anatomic imaging animal imaging cellular imaging data acquisition design education research experience experimental study fluorescence imaging human imaging image processing imaging Segmentation imaging biomarker imaging modality imaging probe imaging science imaging study improved in vivo in vivo imaging kinetic model molecular imaging multimodality neuroimaging neuroimaging marker neuropathology neurotoxicology novel optical imaging professor quantitative imaging radiotracer response structural imaging success targeted imaging therapeutically effective tool toxic organophosphate insecticide exposure virtual

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项目摘要

Project Summary – Neuroimaging Core – Core B The Neuroimaging Core will provide UC Davis CounterACT Center investigators with outstanding resources in the rapidly evolving field of neuroimaging technologies, for which there is strong demand by all three scientific Projects. Neuroimaging tools provide one of the best modern means for examining the pathophysiology of disorders that affect the brain. Center investigators have previously shown the benefits of neuroimaging technologies for evaluating the short- and long-term consequences of acute organophosphate intoxication on the brain and identifying effective therapeutic strategies that mitigate the resulting neuropathology. The Neuroimaging Core will capitalize on these previous successes and provide state-of-the-art equipment for neuroimaging spanning microscopic to whole brain in vivo imaging, and dedicated expertise in image acquisition, analysis and the development and validation of imaging biomarkers to support the scientific Projects. The neuroimaging resources provided will include modalities focused on structural neuroimaging, such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT), functional and molecular imaging, such as MRI and positron emission tomography (PET), and correlative cellular high-content brightfield and fluorescence tissue imaging. Oversight and management of the Neuroimaging Core will be provided by Core Lead, Abhijit Chaudhari, PhD, Professor of Radiology and the Director of the UC Davis Center for Molecular and Genomic Imaging (CMGI), with over 15 years of experience in animal and human imaging with various imaging modalities, quantitative imaging science, imaging biomarker design and validation and medical image processing; and Core Co-Lead, Brad Hobson, PhD, Research Scientist at the CMGI, who has extensive training in neurotoxicology, pharmacology and the validation of ex vivo and in vivo neuroimaging methods in the context of organophosphate exposure. The objectives of the Neuroimaging Core are to: (1) provide Center investigators with access to a wide array of neuroimaging technologies ranging from cellular imaging to macroscopic in vivo structural, functional, and molecular imaging in pursuit of the scientific aims of the Projects; (2) develop and deploy advanced imaging technologies that will enhance Center investigators’ research endeavors.; and (3) contribute to the research education mission of the Center by providing virtual and hands-on training in the utilization of imaging methods, data acquisition, and image analysis. By providing neuroimaging expertise, the Core will ensure that imaging studies by the UC Davis Center investigators are designed, implemented, and analyzed rigorously to ensure transparency, reproducibility and future translatability to humans.

项目摘要 - 神经成像核心 - 核心B 神经影像核心将为UC Davis Rultact Center调查人员提供出色的资源神经影像技术的快速发展的领域，这三种科学的需求强劲项目。神经影像学工具提供了研究的最佳现代手段之一影响大脑的疾病。中心调查人员以前已经显示了神经影像的好处评估急性有机磷酸盐中毒对短期和长期后果的技术大脑并确定减轻由此产生的神经病理学的有效治疗策略。神经影像学核心将利用这些先前的成功，并为神经影像跨越体内大脑的微观成像，并在图像采集方面专门专业知识，分析以及成像生物标志物的开发和验证以支持科学项目。这提供的神经影像资源将包括关注结构神经影像学的方式，例如磁性共振成像（MRI）和X射线计算机断层扫描（CT），功能和分子成像，例如MRI 和正电子发射断层扫描（PET），以及校正细胞高含量的明亮场和荧光组织成像。核心负责人Abhijit Chaudhari将提供对神经影像核心的监督和管理 PhD，放射学教授，加州大学戴维斯分子和基因组成像中心主任（CMGI），具有多种成像方式的动物和人类成像经验超过15年，定量成像科学，成像生物标志物设计，验证以及医学图像处理；和核心 CMGI的CORAD HOBSON，BRAD HOBSON，博士学位，他在神经毒理学方面接受了广泛的培训，在有机磷酸盐的情况下，药理学和体内和体内神经影像学方法的验证接触。神经成像核心的对象是：（1）为中心调查人员提供访问从细胞成像到体内结构的宏观成像，各种各样的神经影像学技术，功能和分子成像，以追求项目的科学目的；（2）开发和部署高级成像技术将增强中心研究人员的研究努力。（3）贡献通过在利用中提供虚拟和动手培训来实现中心的研究教育任务成像方法，数据采集和图像分析。通过提供神经影像学专业知识，核心将确保设计，实施和分析加州大学戴维斯分校中心研究人员的成像研究严格地确保对人类的透明度，可重复性和未来的翻译性。