Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease

慢性鼻窦炎病理生理学和疾病机制的指导

• 批准号: 10723793
• 负责人: Justin H Turner
• 金额: $ 11.6万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-12 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723793
• 关键词: Academic Medical Centers; Adult; Affect; Airway Disease; Bacteria; Biological Markers; Biological Response Modifier Therapy; Biological Specimen Banks; Career Choice; Caring; Cells; Characteristics; Clinical; Clinical Research; Cohort Studies; Collection; Data; Development; Diagnosis; Disease; Educational Status; Elderly; Enrollment; Environmental Risk Factor; Extramural Activities; Faculty; Functional disorder; Funding; Goals; Head and Neck Surgery; Healthcare; Heterogeneity; IL4 gene; Immune; Immunologics; Inflammation; Inflammation Mediators; Inflammatory; Institution; Interferons; Interleukin-13; Interleukin-5; Interleukin-6; Intervention; Knowledge; Link; Measurement; Mediator; Medical Students; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Mucous body substance; Natural Immunity; Nature; Operative Surgical Procedures; Otolaryngology; Outcome Measure; Paranasal Sinus Diseases; Pathogenesis; Pathway interactions; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pattern; Physicians; Population; Postdoctoral Fellow; Prevalence; Productivity; Publications; Quality of life; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scientific Advances and Accomplishments; Scientist; Seasons; Sinus; Specimen; Structure; Surgeon; Time; Tissue Banks; Tissues; Translational Research; United States National Institutes of Health; Work; airway inflammation; aspirin-exacerbated respiratory disease; career; chronic respiratory disease; chronic rhinosinusitis; clinical practice; experience; immunoregulation; improved; improved outcome; individual patient; interest; member; microbial colonization; microbial community; mid-career faculty; minimally invasive; multiple omics; next generation; novel; novel therapeutics; patient oriented; patient oriented research; patient population; personalized approach; personalized care; physical conditioning; programs; prospective; skills; targeted treatment; transcriptomics; translational research program; translational scientist; translational study; undergraduate student

PROJECT SUMMARY Chronic rhinosinusitis (CRS) is a common inflammatory disease that affects a large portion of the U.S. population, resulting in poor quality of life for those affected and utilizing billions of dollars of health care resources. Efforts in my lab have focused on understanding patterns of inflammatory heterogeneity in large CRS populations with a goal of improving disease endotyping and developing personalized care pathways. I am devoted to mentoring the next generation of clinician-scientists in the field of rhinology and chronic rhinosinusitis research. The number of physicians and other surgeons pursuing clinical or translational research is declining, and this is particularly true in the fields of rhinology and otolaryngology. Maintaining a strong pipeline of trainees on research-related career paths is crucial for the development of the subspecialty and scientific advancement of the field. This will be a prospective translational cohort study to identify the clinical implications and longitudinal stability of chronic rhinosinusitis endotypes. We will enroll CRS patients through our well-established biospecimen repository and determine the stability of inflammatory mediator levels and associated endotype assignment over multiple seasons and determine whether these changes are associated with sinonasal microbial community structure. We will also confirm the longitudinal effects of two commonly used immune-modifying interventions (endoscopic sinus surgery and anti-IL4/13R biologic therapy) on inflammatory mediator levels and endotypic assignment. Collectively, these translational studies will substantially advance basic knowledge of a common airway disease that impacts millions of patients, while providing a range of investigative opportunities for mentees interested in CRS and mechanisms of upper airway inflammation. My research program is centered around a patient-oriented approach that incorporates patient-derived specimens, patient-reported outcome measures, and personalized approaches to care. I anticipate that mentee participation in this research program will lead to new and exciting avenues for patient-oriented research to further characterize CRS endotypes and evaluate the effects of targeted therapies; thus, this project will provide a conducive setting for developing the next generation of clinician-scientists in the field. I have a history of continual extramural funding, more than a decade of experience as a mentor to trainees at all levels, and institutional support to enhance my own skills that will augment the support proposed through the K24 mechanism.

项目概要 慢性鼻窦炎 (CRS) 是一种常见的炎症性疾病，影响美国大部分地区。 人口，导致受影响者的生活质量较差，并需要花费数十亿美元的医疗保健 资源。我实验室的工作重点是了解大型 CRS 中炎症异质性的模式 以改善疾病内型和开发个性化护理途径为目标的人群。我是 致力于指导鼻科和慢性鼻窦炎领域的下一代临床医生科学家 研究。从事临床或转化研究的内科医生和其他外科医生的数量正在下降， 在鼻科和耳鼻喉科领域尤其如此。维持强大的学员渠道 与研究相关的职业道路对于专业的发展和科学进步至关重要 领域的。这将是一项前瞻性转化队列研究，旨在确定临床意义和纵向研究 慢性鼻窦炎内型的稳定性。我们将通过我们完善的机构来招募 CRS 患者 生物样本库并确定炎症介质水平和相关内型的稳定性 多个季节的分配并确定这些变化是否与鼻腔微生物有关 社区结构。我们还将确认两种常用免疫调节剂的纵向效应 干预措施（内窥镜鼻窦手术和抗 IL4/13R 生物治疗）对炎症介质水平和 内型分配。总的来说，这些转化研究将极大地推进基础知识的发展 影响数百万患者的常见气道疾病，同时提供一系列研究机会 适合对 CRS 和上呼吸道炎症机制感兴趣的学员。我的研究计划集中在 围绕以患者为中心的方法，结合患者来源的标本、患者报告的结果 措施和个性化的护理方法。我预计受训者参与该研究计划 将为以患者为导向的研究带来新的、令人兴奋的途径，以进一步表征 CRS 内型和 评估靶向治疗的效果；因此，该项目将为发展 该领域的下一代临床医生科学家。我有持续获得校外资助的历史，超过 十年作为各级学员的导师的经验，以及提高我自己技能的机构支持 将增加通过K24机制提出的支持。

项目成果

Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis.

颗粒物暴露与慢性鼻窦炎中炎症细胞因子和嗜酸性粒细胞增加有关。

• DOI: 10.1111/all.16006
• 发表时间: 2024-01-05
• 期刊: Allergy
• 影响因子: 12.4
• 作者: R. Lubner;Kolin E. Rubel;Rakesh K Ch;ra;ra;Justin H. Turner;Naweed I Chowdhury
• 通讯作者: Naweed I Chowdhury