Sensory control of a motor sequence

运动序列的感觉控制

• 批准号: 10683031
• 负责人: JULIE H SIMPSON
• 金额: $ 8.16万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683031
• 关键词: Address; Afferent Neurons; Amaze; Anatomy; Animal Behavior; Animal Model; Animals; Anterior; Back; Behavior; Behavior Control; Behavioral; Behavioral Assay; Body part; Brain; Complex; Computer software; Cues; Data; Disease; Dissection; Drosophila genus; Dystonia; Elements; Environment; Equilibrium; Exercise; Feedback; Floods; Functional Imaging; Genetic; Genetic Models; Genetic Screening; Grooming; Head; Human; Interneurons; Knowledge; Label; Leg; Light; Logic; Maps; Measures; Methods; Modality; Modeling; Motor; Motor Neurons; Motor output; Movement; Muscle; Nervous system structure; Neurobiology; Neurons; Obsessive-Compulsive Disorder; Parkinson Disease; Population; Probability; Reflex action; Reflex control; Resolution; Sensory; Sensory Process; Signal Transduction; Specific qualifier value; Stimulus; System; Testing; Time; Update; automated analysis; base; behavior test; dopaminergic neuron; flexibility; fly; motor control; multisensory; neural circuit; neural patterning; novel strategies; optogenetics; relating to nervous system; sensory input; sensory stimulus; stereotypy; tool

Abstract Animals collect sensory information from their environment and use it to select among the many behaviors they can perform. The exact neural circuits that enable them to detect, compare, and combine sensory stimuli across space and time to organize motor sequences remain unknown. Grooming behavior in Drosophila is a sensory-driven motor sequence. We propose to use optogenetic tools and behavioral analysis to identify the sensory neurons and circuits relevant for initiation and progression of the fly grooming sequence. Grooming is innate – the basic capacity to groom is inborn, relying on genetically-specified neural connections, and therefore accessible to dissection by genetic screens. But the sequence of the actions that constitute grooming is flexible: there is a high probability that head sweeps and front leg rubs will occur early and that back leg subroutines to clean the posterior body parts will happen later, but the exact order of these movements is not fixed. Flies use updating sensory cues to modify the trajectory of leg sweeps, the duration of cleaning bouts, and the order of movements to remove different distributions of debris effectively. A deep mechanistic understanding of how the nervous system organizes reliable but adaptive motor sequences will address the larger questions of how animals make use of a flood of sensory data, how they balance the need to exercise a movement precisely with the need to modify it based on context, and how a limited number of neurons produce the diverse array of animal behaviors. Neural circuit motifs form the basic computational units of all nervous systems. Defining the circuits that accomplish sensory comparisons that control a motor sequence in a simpler system such as fly grooming will provide a template for understanding how similar functions are achieved in all brains.

抽象的 动物从其环境中收集感官信息，并用它在许多人中进行选择 他们可以执行的行为。使它们能够检测，比较和 在整个空间和时间组织运动序列的时空结合感觉刺激仍然未知。 果蝇中的修饰行为是一种感官驱动的运动序列。我们建议使用 光遗传学工具和行为分析以识别相关的感觉神经元和电路 用于苍蝇修饰序列的启动和进展。修饰是天生的 - 基本 修饰能力是天生的，依靠一般指定的神经元连接，因此 可以通过遗传筛查来解剖。但是构成行动的顺序 修饰是灵活的：很可能会发生头部糖和前腿摩擦 早期和后腿子例程以清洁后身体部位会发生，但是 这些运动的确切顺序不是固定的。苍蝇使用更新感官提示来修改 腿部甜食的轨迹，清洁的持续时间以及移动的顺序去除 有效的不同分布分布。 对神经系统如何组织可靠但适应性的深刻理解 运动序列将解决动物如何利用洪水的更大问题 感官数据，他们如何平衡精确行动的需求与需要 根据上下文修改它，以及有限数量的神经元如何产生潜水员的数组 动物行为。神经回路图案形成了所有神经的基本计算单元 系统。定义完成控制电动机的感觉比较的电路 在较简单的系统（例如苍蝇修饰）中的序列将为理解提供模板 在所有大脑中，如何实现相似的功能。