Muscle Fatigue's Impact on Gait Mechanics and Neuromuscular Control in Knee Osteoarthritis

肌肉疲劳对膝骨关节炎步态力学和神经肌肉控制的影响

• 批准号: 10676554
• 负责人: Skylar Holmes
• 金额: $ 4.49万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-21 至 2025-09-20
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676554
• 关键词: Accelerometer; Acute; Address; Adopted; Adult; Age; Ankle; Arthralgia; Biomechanics; Chronic; Cross-Sectional Studies; Data; Degenerative polyarthritis; Development; Distal; Elderly; Electromyography; Evaluation; Exercise; Extensor; Fatigue; Female; Flexor; Functional disorder; Gait; Goals; Hip region structure; Impairment; Individual; Intervention; Investigation; Isometric Exercise; Isotonic Exercise; Joints; Knee; Knee Osteoarthritis; Knowledge; Link; Measures; Mechanics; Medical; Mission; Monitor; Motion; Motor; Motor Cortex; Movement; Muscle; Muscle Fatigue; Muscle function; Muscular Atrophy; Musculoskeletal; Neurologic; Neuromechanics; Neuronal Plasticity; Numeric Rating Scale; Pain; Pattern; Peripheral; Persons; Physical Capacity; Physical Function; Physical Performance; Physical activity; Physiological; Population; Psyche structure; Public Health; Reporting; Research Design; Research Personnel; Severities; Source; Speed; Spinal Cord; Standardization; Symptoms; Testing; Time; Torque; Training; Transcranial magnetic stimulation; United States National Institutes of Health; Vulnerable Populations; Walking; Woman; Work; aging population; chronic pain; clinically relevant; disability; functional improvement; healthspan; improved; improved mobility; male; men; neuromuscular; neuromuscular function; neurophysiology; novel strategies; prevent; response; sedentary; sensory system; skill acquisition; treadmill; verbal; years lived with disability

Project Summary Fatigue, lack of physical and/or mental energy, is a common reported symptom with osteoarthritis (OA) that may limit physical capacity and contribute to disability. In healthy older adults, muscle fatigue has been proposed as a key contributor to symptoms of fatigue. Knee extensor muscle dysfunction, including lower isometric and isokinetic torques and altered muscle activation patterns, are common with knee osteoarthritis (KOA). Together these changes in neuromuscular function may increase locomotor muscle fatigue in KOA compared to age-matched controls, as a greater percentage of the muscle’s capacity must be used for daily activities such as walking. To date, evidence to explain whether and how muscle fatigue may alter control and coordination of movement in KOA is limited. Our working hypothesis is that KOA-related neuromuscular changes may exacerbate locomotor muscle fatigue (Aim 1) and alter the neuro-mechanical response to muscle fatigue during gait (Aim 2), thereby contributing to mobility declines. In healthy adults, central and peripheral mechanisms can both contribute to muscle fatigue. However, whether the source of fatigue in individuals with KOA is central or peripheral is unclear which may be due to maladaptive neuroplastic changes that occur with KOA. To assess and compare the mechanisms for loss of force with a prolonged walk in individuals with KOA we will use transcranial magnetic stimulation to measure motor cortex excitability and inhibition (Aim 3). To test these hypotheses, data will be gathered on 2 groups of 10 men and 10 women: KOA (65-80 years) and older healthy controls (70-80 years). Both groups will be relatively sedentary, which will be verified quantitatively using accelerometry. In this cross-sectional study design, we will implement our new physiologically and clinically relevant 30-minute treadmill walk to induce knee extensor muscle fatigue and then quantify the response with measures of gait mechanics, electromyography, physical performance, and motor cortex excitability. The problem to be addressed, muscle fatigue in KOA, and its impact on mobility is significant and currently prevents many older adults from achieving an optimal health span. Understanding the mechanisms underlying changes in physical function, such as muscle fatigue in individuals with KOA will allow for a better understanding of how to optimize interventions in this population. The completion of the project and the proposed training plan activities including skill development in new experimental and advanced computational approaches as well as professional development activities will have a significant, positive impact on the development of the PI as an independent researcher, contributing to the stated goals of the NIH to enhance training of a diverse work force.

项目摘要 疲劳，缺乏身体和/或精神能量，是骨关节炎（OA）的常见症状， 可能会限制身体能力并导致残疾。在健康的老年人中，肌肉疲劳一直 提议作为疲劳症状的关键因素。膝盖外部肌肉功能障碍，包括较低 等距和同动扭矩和改变的肌肉激活模式，膝关节骨关节炎很常见 （KOA）。神经肌肉功能的这些变化可能会增加KOA中的运动肌肉疲劳 与年龄匹配的对照相比，每天都必须使用肌肉能力的百分比 诸如步行之类的活动。迄今为止，有证据来解释肌肉疲劳是否可能改变控制和 KOA运动的协调是有限的。我们的工作假设是与KOA相关的神经肌肉 变化可能加剧运动肌肉疲劳（AIM 1），并改变对肌肉的神经机械反应 步态期间的疲劳（AIM 2），从而导致流动性下降。在健康的成年人中，中央和周边 机制都可以导致肌肉疲劳。但是，是否在患有 KOA是中心的，或者外围是不清 KOA。评估和比较KOA的个体长时间步行的力量损失机制 我们将使用经颅磁刺激来测量运动皮层令人兴奋和抑制作用（AIM 3）。到 测试这些假设，数据将收集到2组男性和10名女性：KOA（65 - 80年）和 较旧的健康对照（70 - 80年）。两组将是相对久坐的，将被验证 定量使用加速度测定法。在这种横断面研究设计中，我们将实施新的 在生理和临床上相关的30分钟跑步机步行以诱发膝盖伸展肌肉疲劳和 然后用获得力学，肌电图，身体性能和 运动皮层令人兴奋。要解决的问题，KOA的肌肉疲劳及其对移动性的影响是 意义重大，目前阻止许多老年人获得最佳的健康跨度。理解 身体机能发生变化的机制，例如KOA患者的肌肉疲劳将会 可以更好地了解如何优化该人群的干预措施。完成 项目和拟议的培训计划活动，包括新实验和 高级计算方法以及专业发展活动将具有重要的 对PI作为独立研究人员的发展的积极影响，为既定目标做出了贡献 NIH以增强对潜水员劳动力的培训。