Transdisciplinary Training In Cardiovascular Research

心血管研究的跨学科培训

• 批准号: 10671631
• 负责人: J Kevin Donahue
• 金额: $ 50.83万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671631
• 关键词: Cardiovascular system; Research; Training

ABSTRACT We propose the 1st competitive renewal of our transdisciplinary cardiovascular sciences training program (CVT32) at the University of Massachusetts Medical School (UMMS). We will continue to encompass the full spectrum of cardiovascular (CV) research from basic to population health. This breadth is part of the UMMS culture of conducting science that makes a difference. The CVT32 is a collaboration between the Division of Cardiovascular Medicine in the Department of Medicine and the Department of Population and Quantitative Health Sciences (PQHS) and involves 48 participating faculty from multiple departments. Our two MPIs have different research expertise, with one (Freedman) more in the bench through phase 1 clinical trials arena and the other (Kiefe) in the phase 2/3 clinical trials (efficacy) through effectiveness, implementation, and population-sciences arena. Trainees will have mentoring teams with a lead mentor in their CV area of interest and a co-mentor plus an additional mentor-in-training representing very different areas of research. The synergism of our CVT32 faculty spanning the entire spectrum is a unique strength of our CVT32 enabling us to train scientists in a transdisciplinary way, with bidirectional hypothesis generation. Team mentoring and hands-on research experience through the entire training period are key components of our CVT32, together with structured coursework and abundant enrichment activities tailored to the individual trainee. We have a doctoral program and a Masters of Science of Clinical investigation housed in PQHS, where all CVT32 trainees will each have their own cubicle, in close physical proximity to researchers across the spectrum. Building on the success of our 1st funding period, we propose to enlarge the program by attaining a steady-state of 4 postdoctoral trainees and 4 predoctoral trainees at a time, with terms of 2-3 years; and newly adding a 12-week summer research training experiences for 8 medical students/year enrolled in a 4-year clinical and translational research pathway. Thus, our aims are to 1) Expand our successful CVT32 across basic, clinical, and population health sciences geared towards translating research into effective clinical practice and policy, and generating new questions spanning the entire spectrum of CV research. 2) Recruit pre-and post- doctoral trainees forming a diverse group regarding sociodemographics, clinical background, and disciplinary perspectives. 3) Provide trainees with the individual mentoring, academic training, and technical skills that will ensure their success as independent investigators as well as contributors to team science. 4) Provide “hands on” research experiences within transdisciplinary teams that build on the strengths of the current environment of linkages between UMMS Departments, Centers, and Institutes.

抽象的 我们提出了跨学科心血管科学训练的第一竞争性更新 马萨诸塞大学医学院（UMMS）的计划（CVT32）。我们将继续 涵盖了从基本人群健康到人口健康的全部心血管（CV）研究。这个广度 是导致有所作为的科学文化的一部分。 CVT32是一项合作 在医学系心血管医学部和部门之间 人口和定量健康科学（PQHS），涉及48个来自多个的参与教师 部门。 我们的两个MPI具有不同的研究专业知识，通过 第1阶段临床试验竞技场和其他（KIEFE）在第2/3阶段临床试验（疗效）中 有效性，实施和人口界领域。学员将拥有心理团队 在他们感兴趣的简历领域具有铅心态，并有一个培训的额外心态 代表非常不同的研究领域。我们的CVT32教师的协同作用跨越了整个 Spectrum是我们CVT32的独特优势，使我们能够以跨学科的方式培训科学家， 与双向假设产生。团队指导和动手研究经验 整个培训期是我们CVT32的关键组成部分，以及结构化的课程和 量身定制的丰富丰富活动。我们有一个博士课程和 PQHS中安置的临床调查科学硕士 他们自己的隔间与整个领域的研究人员非常接近。 在我们第一次融资期的成功的基础上，我们建议通过达到一个计划来扩大该计划 一次稳态的4个博士后学员和4位占主导地位的学员，期限为2 - 3年； 并新添加了为8名医学生的12周夏季研究培训经验 参加了为期4年的临床和翻译研究途径。 这是我们的目标是1）扩大我们成功的CVT32在基本，临床和人口健康中 旨在将研究转化为有效的临床实践和政策，并产生的科学 新问题涵盖了CV研究的整个范围。 2）招募博士后学员 组建一个有关社会人口统计学，临床背景和纪律处分的多元化群体 观点。 3）为受训者提供个人的心理，学术培训和技术技能 这将确保他们作为独立研究人员以及团队科学的贡献者的成功。 4） 在跨学科团队内提供“动手”研究经验，以此为基础 UMMS部门，中心和机构之间的当前联系环境。

项目成果

Interest in and barriers to participation in a Facebook-delivered weight loss program among female cancer survivors with overweight or obesity.

• DOI: 10.21037/mhealth.2019.08.02
• 发表时间: 2019-01-01
• 期刊: mHealth
• 作者: May, Christine N;Jake-Schoffman, Danielle E;Pritschmann, Ricarda K
• 通讯作者: Pritschmann, Ricarda K

Perceived weight status and weight change among a U.S. adult sample.

美国成人样本中的感知体重状况和体重变化。

• DOI: 10.1002/oby.21685
• 发表时间: 2017
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Wang,MonicaL;Haughton,ChristinaF;Frisard,Christine;Pbert,Lori;Geer,Christine;Lemon,StephenieC
• 通讯作者: Lemon,StephenieC

Chromatin Compaction in Noncompaction Cardiomyopathy.

非致密化心肌病中的染色质致密化。

• DOI: 10.1161/circresaha.123.323015
• 发表时间: 2023
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Cashman,TimothyJ;Trivedi,ChinmayM
• 通讯作者: Trivedi,ChinmayM

Usefulness of Self-Reported Physical Activity and Clinical Outcomes in Older Patients With Atrial Fibrillation.

• DOI: 10.1016/j.amjcard.2022.07.010
• 发表时间: 2022-10-15
• 期刊: AMERICAN JOURNAL OF CARDIOLOGY
• 影响因子: 2.8
• 作者: Dai, Qiying;Mehawej, Jordy;Saczynski, Jane S.;Khanh-Van Tran;Abu, Hawa O.;Lessard, Darleen;Fillippaios, Andreas;Paul, Tenes;Hariri, Essa;Wang, Weijia;Tisminetzky, Mayra;Soni, Apurv;Howard-Wilson, Sakeina;Waring, Molly E.;Goldberg, Robert J.;McManus, David D.
• 通讯作者: McManus, David D.

Spirituality and Physical Activity and Sedentary Behavior among Latino Men and Women in Massachusetts.

• DOI: 10.18865/ed.27.1.3
• 发表时间: 2017-01
• 期刊: Ethnicity & disease
• 影响因子: 3.2
• 作者: Valerie J Silfee;Christina F. Haughton;S. Lemon;Vilma Lora;M. Rosal