Systems-Level Research in Microbial Pathogenesis

微生物发病机制的系统级研究

• 批准号: 10671611
• 负责人: NICHOLAS H CARBONETTI
• 金额: $ 37.83万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671611
• 关键词: Pathogenesis; Research; System; microbial

PROJECT SUMMARY This training program in “Systems-Level Research in Microbial Pathogenesis” will formalize and strengthen interdisciplinary research in microbial pathogenesis and high-throughput science that interrogates parasites, fungi, bacteria, and viruses more completely at the systems-level. The University of Maryland Baltimore has exceptional strength and depth in microbiology, infectious disease, vaccinology, genomics, and bioinformatics with >100 faculty with research in these areas. The nineteen senior training faculty and seven junior training faculty are drawn from the world class microbial pathogenesis research programs in the Schools of Medicine, Dentistry, and Pharmacy; including scientists from two of the university's internationally renowned research institutes—the Center for Vaccine Development and the Institute for Genome Sciences. These faculty have >1000 publications in the past ten years and 93 grants with average direct costs of $1,707,495/year. They will develop and participate in a new graduate course targeting these trainees that is aimed at interdisciplinary research at the intersection of microbial pathogenesis and systems-level research. Predoctoral trainees will be selected from two interdepartmental doctoral programs that include a common core curriculum, elective courses, journal clubs, seminars, annual symposia, and graduate research presentations. The selected predoctoral students will also include trainees from the School of Medicine MD/PhD program and the School of Dentistry DDS/PhD program. Academic work will be combined with rigorous mentored research training in the research groups of the training faculty, who have current and past training grant eligible predoctoral trainees with an average of 4.0 publications/trainee. Postdoctoral trainees will be selected through recruitment of new fellows to the University of Maryland Baltimore. Our training grant eligible postdoctoral trainees have been equally productive with 4.5 publications/trainee. The program is guided by a highly qualified team of three Co- Directors (MPIs) with two serving as track leaders, as well as an internal Executive Committee. An External Advisory Committee has also been established that will evaluate the program. Our trainees will be further focused on systems-level research in microbial pathogenesis through a change in our curriculum, as well as unique opportunities that will aid in recruitment and development of more students in this area. Programs that distinguish trainees from the larger pool of graduate students, to promote and enhance their training, include (i) oral presentations at the annual University of Maryland intercampus Crosstalk symposium, (ii) regular training program research meetings, (iii) teaching opportunities in graduate and medical courses, (iv) opportunities to present at national or international conferences, (v) opportunities to present in internal seminar series, (vi) formalized career mentoring and career-focused networking, and (vii) formal training in mentorship and mentoring an undergraduate or high school student from groups typically underrepresented in science, helping to build our robust pipeline for developing diverse scientists.

项目概要 本次“微生物发病机制系统级研究”培训计划将正式化并加强 微生物发病机制和寄生虫高通量科学的跨学科研究， 马里兰大学巴尔的摩分校在系统层面上更完整地研究了真菌、细菌和病毒。 在微生物学、传染病、疫苗学、基因组学和生物信息学方面具有非凡的实力和深度 拥有超过 100 名在这些领域进行研究的教师，其中 19 名高级培训教师和 7 名初级培训教师。 教职员工来自医学院世界一流的微生物发病机制研究项目， 牙科和药学；包括来自该大学两个国际知名研究领域的科学家 研究所——疫苗开发中心和基因组科学研究所。 过去 10 年发表了超过 1000 篇出版物，并获得了 93 项资助，平均直接成本为每年 1,707,495 美元。 开发并参与针对这些学员的新研究生课程，该课程旨在跨学科 博士前学员将进行微生物发病机制和系统级研究的交叉研究。 从两个跨部门的博士课程中选出，其中包括共同的核心课程、选修课 课程、期刊俱乐部、研讨会、年度研讨会和研究生研究报告。 博士前学生还包括来自医学院 MD/PhD 项目和医学院的学员 牙科 DDS/博士课程将与严格的指导研究培训相结合。 培训教师的研究小组，他们拥有当前和过去的培训补助金合格的博士前学员 平均4.0篇论文/实习生将通过新招聘选拔。 我们的马里兰大学巴尔的摩分校的研究员已获得符合资格的博士后实习生。 与 4.5 份出版物/实习生同样高效 该计划由三名合作伙伴组成的高素质团队指导。 董事 (MPI)，其中两名担任领导者，以及一个内部执行委员会和一个外部执行委员会。 咨询委员会也已成立，将进一步评估我们的学员。 通过改变我们的课程，专注于微生物发病机制的系统级研究，以及 独特的机会将有助于招募和发展更多该领域的学生。 将受训者与更多的研究生区分开来，以促进和加强他们的培训，包括（i） 在马里兰大学年度 Crosstalk 研讨会上进行口头报告，(ii) 定期培训 项目研究会议，(iii) 研究生和医学课程的教学机会，(iv) 出席国内或国际会议，(v) 有机会参加内部研讨会系列，(vi) 正式的职业指导和以职业为中心的网络，以及 (vii) 指导和培训方面的正式培训 指导来自科学界通常代表性不足的群体的本科生或高中生，帮助 为不同的发展中的科学家建立强大的管道。