Prenatal environmental determinants of health in young adulthood: a lifecourse approach

成年早期健康的产前环境决定因素：生命全程方法

基本信息

批准号：
10670190
负责人：
Marie-France Hivert
金额：
$ 135.4万
依托单位：
HARVARD PILGRIM HEALTH CARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-07-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670190
关键词：
Address Adolescence Adult Adverse effects Air Pollution Animal Experiments Behavior Behavior Disorders Behavioral Biological Biological Markers Biology Birth Blood Pressure Bone Density Characteristics Chemicals Child Child Behavior Childhood Chronic Disease Data Data Collection Development Diet Disease Eating Behavior Elderly Elements Environment Ethnic Origin Exposure to Fertility Funding Future Growth Health Health Status Health behavior Hormones Human Hyperglycemia Hypertension Individual Inflammation Life Life Cycle Stages Life Style Lipids Long-Term Effects Longevity Longitudinal cohort Maternal Behavior Measurement Measures Mediator Menstrual cycle Metal exposure Metals Methods National Institute of Child Health and Human Development Neighborhoods Obesity Outcome Participant Personal Satisfaction Physical activity Policies Population Positioning Attribute Pregnancy Productivity Protocols documentation Psychology Public Health Quality of life Race Reproductive Health Research Research Personnel Resources Risk Factors Schools Selection Bias Seminal fluid Sleep Sleep Deprivation Smoking Social Environment Teenagers Thinness Time Tobacco Translating Unhealthy Diet Weight Weight Gain Woman analytical method anxiety symptoms blood pressure elevation cardiometabolism cohort depressive symptoms deprivation disorder risk experience follow-up health determinants improved innovation interest lean body mass lung health maternal cigarette smoking men offspring optimism prenatal prenatal experience prenatal exposure prevent prospective reproductive sample collection sedentary activity sex social social factors sperm quality substance use theories tv watching waist circumference young adult

项目摘要

Summary/Abstract Young adulthood is the life stage when we should achieve peak health. Physically, young adults will have completed their growth, reached maximal lean body mass, and have optimal fertility. Many young adults will have completed school and live independently. While few young adults have overt chronic disease, many already have substantial risk factors such as hypertension, hyperglycemia, and obesity. Moreover, suboptimal lifestyle behaviors such as poor diet, insufficient sleep, and substance use, and symptoms of depression and anxiety prevent many young adults from reaching their full potential. Existing evidence suggests that the prenatal environment influences health and disease risks across the lifecourse. However, most human evidence is based on either short-term follow-up into childhood, when health is more plastic; or on retrospective data from adult cohorts in which exposures are limited or subject to substantial recall bias, and selection bias is likely considerable yet unquantifiable. The proposed project will address this topic leveraging the rich data already collected in the Project Viva pre- birth cohort. The project will include already-collected measures of prenatal maternal behaviors (diet, smoking, physical activity) and biology (inflammation, blood pressure, glycemia, weight gain, depressive/anxiety symptoms), as well as elements of the chemical (exposures to metals, PFAS, air pollution) and social environments (material hardship, neighborhood deprivation). Specific Aims will focus on following key domains of health to be assessed in 1000 young adults followed since prenatal life: Aim 1: Cardiometabolic Health, based on weight, waist circumference, blood pressure, and biomarkers (lipids, glycemia, inflammation). Aim 2: Reproductive Health, based on fertility markers including hormone levels, menstrual cycle characteristics (for women), and sperm quality/quantity (for men). Aim 3: Experiential Health and Wellbeing, based on perceived overall health and quality of life, measures of positive psychology (e.g. optimism), and low levels of depressive/anxiety symptoms Secondary Aim 4: Health behaviors, including diet and eating behaviors, physical and sedentary activities, tobacco and other substance use, and sleep. The primary hypothesis is that a more beneficial prenatal environment will be associated with better cardiometabolic, reproductive, and experiential health in young adulthood. Project Viva is uniquely positioned to address these important scientific questions. Ongoing support of this unique resource will provide an unparalleled opportunity to rigorously evaluate the extent to which developmental exposures influence health into adulthood.

摘要/摘要年轻成年是我们应该达到峰值健康的生活阶段。身体上，年轻人将有完成生长，达到最大的瘦体重，并具有最佳的生育能力。许多年轻人将已经完成学校并独立生活。尽管很少有年轻人患有明显的慢性疾病，但许多已经有大量的危险因素，例如高血压，高血糖和肥胖。而且，次优生活方式行为，例如饮食不良，睡眠不足和吸毒以及抑郁症的症状和焦虑阻止许多年轻人发挥全部潜力。现有证据表明，产前环境会影响整个人的健康和疾病风险生命。但是，大多数人类证据是基于任何短期随访儿童时期的证据更塑料；或关于来自成人队列的回顾性数据，其中暴露是限制或受到的实质性的召回偏见和选择偏见可能是相当大但无法量化的。拟议的项目将解决此主题，以利用项目viva预先收集的丰富数据出生队列。该项目将包括已经收集的产前孕产妇行为的措施（饮食，吸烟，体育锻炼）和生物学（炎症，血压，血糖，体重增加，抑郁/焦虑症状）以及化学元素（对金属，PFA，空气污染的暴露）和社会环境（物质困难，邻里剥夺）。具体目标将集中于以下关键领域自从产前生活以来，在1000名年轻人中将评估健康的健康：目标1：基于体重，腰围，血压和生物标志物的心脏代谢健康（脂质，血糖，炎症）。 AIM 2：基于包括激素水平的生育标记，生殖健康，月经周期特征（女性）和精子质量/数量（男性）。目标3：基于感知的整体健康和生活质量的体验式健康和福祉积极的心理学（例如乐观）和低水平的抑郁/焦虑症状次要目标4：健康行为，包括饮食和饮食行为，身体和久坐的活动，烟草和其他药物使用，并睡觉。主要的假设是，更有益的产前环境将与更好成年年轻人的心脏代谢，生殖和体验式健康。 Viva项目独特地定位解决这些重要的科学问题。对这种独特资源的持续支持将为无与伦比的机会严格评估发育暴露影响健康的程度成年。

项目成果

期刊论文数量（306）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Longitudinal association of maternal attempt to lose weight during the postpartum period and child obesity at age 3 years.

母亲产后减肥尝试与 3 岁时儿童肥胖的纵向关联。

DOI：
10.1038/oby.2011.25
发表时间：
2011
期刊：
Obesity (Silver Spring, Md.)
影响因子：
0
作者：
Sonneville,KendrinR;Rifas-Shiman,SherylL;Oken,Emily;Peterson,KarenE;Gortmaker,StevenL;Gillman,MatthewW;Taveras,ElsieM
通讯作者：
Taveras,ElsieM

Associations of hypertensive disorders of pregnancy and gestational diabetes mellitus with menopausal symptoms at midlife in Project Viva.

DOI：
10.1097/gme.0000000000002014
发表时间：
2022-09-01
期刊：
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
影响因子：
2.7
作者：
Soria-Contreras, Diana C.;Perng, Wei;Rifas-Shiman, Sheryl L.;Minguez-Alarcon, Lidia;Hivert, Marie-France;Shifren, Jan;Oken, Emily;Chavarro, Jorge E.
通讯作者：
Chavarro, Jorge E.

Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.

DOI：
10.1002/oby.23261
发表时间：
2021-11
期刊：
Obesity (Silver Spring, Md.)
影响因子：
0
作者：
Wu AJ;Aris IM;Rifas-Shiman SL;Oken E;Taveras EM;Chavarro JE;Hivert MF
通讯作者：
Hivert MF

Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.

产前物质暴露和儿童行为结果的潜在类别分析。

DOI：
10.1016/j.jpeds.2023.113468
发表时间：
2023
期刊：
The Journal of pediatrics
影响因子：
0
作者：
Maylott,SarahE;Conradt,Elisabeth;McGrath,Monica;Knapp,EmilyA;Li,Xiuhong;Musci,Rashelle;Aschner,Judy;Avalos,LyndsayA;Croen,LisaA;Deoni,Sean;Derefinko,Karen;Elliott,Amy;Hofheimer,JulieA;Leve,LeslieD;Madan,JulietteC;Manso
通讯作者：
Manso

Infant growth and child cognition at 3 years of age.