San Antonio Claude D. Pepper Older Americans Independence Center

圣安东尼奥克劳德·D·佩珀美国老年人独立中心

• 批准号: 10670118
• 负责人: RANDY STRONG
• 金额: $ 124.26万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670118
• 关键词: 4 year old; Acceleration; Aging; Alzheimer' s disease pathology; American; Awareness; Behavior Therapy; Biology of Aging; Biometry; Callithrix; Capsicum; Cell Aging; Chronic Disease; Clinical; Clinical Pharmacology; Clinical Research; Clinical Trials; Clinical Trials Design; Cognitive; Collaborations; Communities; Development; Diamond; Disease; Education; Elderly; Epigenetic Process; Exercise; Foundations; Funding; GDF8 gene; Gerontology; Geroscience; Goals; Grant; Human; Immune; Inflammation; Informatics; Infrastructure; Institution; Intervention; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Longevity; Maintenance; Mediator; Metabolic dysfunction; Metformin; Methylene blue; Mitochondria; Modeling; Monkeys; Oxytocin; Patients; Pharmacology; Phase; Pilot Projects; Play; Policy Maker; Principal Investigator; Process; Qualifying; Research; Research Design; Research Personnel; Research Support; Resources; Scientist; Series; Services; Shock; Sirolimus; Site; Testing; Training; Translating; bench to bedside; clinical center; data management; disability; drug development; dysbiosis; education research; exhaustion; first-in-human; frailty; gut microbiome; healthspan; healthy aging; human disease; improved; innovation; knowledge base; lifestyle intervention; mTOR Inhibitor; meetings; microbiome; mild cognitive impairment; multidisciplinary; nonhuman primate; nutrition; operation; oral microbiome; pharmacologic; pre-clinical research; programs; recruit; sarcopenia; senescence; skills; square foot; stem cells; stress reduction; symposium; trial design; web site

A core tenet of the geroscience concept is that multiple human diseases arise from aging itself. Thus, the central theme of the San Antonio (SA) Claude D. Pepper Older Americans Independence Center (OAIC) is translational geroscience – moving research on the basic biology of aging from the laboratory bench to the clinic, with the overarching goal of promoting healthy aging and developing desperately needed treatments, mainly pharmacological, for aging-related diseases. This goal is achieved through the following Aims: 1) Expand the knowledge base in translational geroscience by catalyzing transformative research; 2) Create a cadre of multidisciplinary early-stage investigators with customized expertise in translational geroscience; 3) Serve as a resource and partner to investigators from other OAICs and institutions; and 4) Provide intellectual leadership, disseminate knowledge, and stimulate discussion on translational geroscience-related themes. The SA OAIC achieves these Aims through a Leadership and Administrative Core (LAC) that directs operations and sponsors several enrichment and dissemination activities; a Pilot and Exploratory Studies Core (PESC) that provides merit-based support for rigorously designed studies; a Research Education Component (REC) that expands a greatly needed cadre of uniquely qualified scientists cross-trained in aging biology and translational geroscience; a Pre-Clinical Research Core (RC1) which supports research in marmoset monkeys; a Clinical Research and Pharmacology Core (RC2) that delivers comprehensive trial support for recruitment/retention, assessments, pharmacology, and data management; and a Trial Design and Integrative Informatics Core (RC3) that provides comprehensive study design, biostatistics and informatics services. During the ~4 years since its funding, the SA OAIC supported 46 PIs, performing transformative translational geroscience-focused research in essentially all pillars/hallmarks of aging. For example, RC1 is conducting the only known lifespan and healthspan study on mTOR inhibitors in nonhuman primates. RC2 and RC3 carried out the first trial on rapamycin to examine immune and cognitive effects in healthy older adults and performed the first-in-man studies on senolytics. The OAIC supported 10 Scholars who are making transformative discoveries (e.g. first demonstration of cellular senescence as a key mediator of Alzheimer's pathology) and receiving highly competitive career development awards from the NIA/AFAR (Beeson, Irene Diamond) and the VA. The SA OAIC is built on a unique foundation provided by UTHSCSA's exceptional and tightly integrated resources: a Nathan Shock Center, a site of the Interventions Testing Program (ITP), a GRECC, a T32 Training Grant on Geroscience, and a robust Barshop Institute that unites aging research at UTHSCSA. We are the only OAIC with all of these synergistic components available. In addition, the SA OAIC receives unparalleled institutional commitment (~$600,000/year), including a new ~$100M 109,000 sq. ft. building – specific for the Barshop Institute – that will house the OAIC, Shock Center, and the ITP in a centrally located facility.

Geroscience概念的核心原则是，多种人类疾病是由衰老本身引起的。那， 圣安东尼奥（SA）Claude D. Pepper老年美国人独立中心（OAIC）的中心主题 是转化性的Geroscience - 将衰老基本生物学的研究从实验室台上转移到 诊所，其总体目标是促进健康的衰老和开发迫切需要的治疗， 主要是药物，用于与衰老有关的疾病。通过以下目标实现了这个目标： 1）通过催化变革性研究来扩大转化性敏捷的知识基础； 2）创建 具有自定义专业知识的跨学科早期研究人员的干部； 3） 作为其他OAIC和机构的调查人员的资源和合作伙伴； 4）提供直觉 领导，传播知识并刺激与转化与科学相关的主题的讨论。 SA OAIC通过指导的领导和行政核心（LAC）实现这些目标 运营并赞助几种酶和传播活动；试点和探索性研究核心 （PESC）为严格设计的研究提供基于优点的支持；研究教育部分 （REC）扩大了巨大必需的独特资格科学家的干部，这些科学家在衰老的生物学和 翻译的Geroscience；临床前研究核心（RC1），该核心支持马尔莫斯猴的研究； 临床研究和药理学核心（RC2），为 招聘/保留，评估，药理学和数据管理；以及试验设计和综合性 提供全面的研究设计，生物统计学和信息服务的信息学核心（RC3）。 在资金以来的大约4年中，SA OAIC支持46个PI，进行变革性翻译 基本上以所有衰老的支柱/标志为重点的研究。例如，RC1正在执行 仅对非人类隐私的MTOR抑制剂进行了已知的寿命和健康范围研究。 RC2和RC3进行 关于雷帕霉素的第一次试验，以检查健康老年人的免疫和认知作用，并进行了 人塞溶剂的第一人类研究。 OAIC支持了10名正在变革性发现的学者 （例如，首次演示细胞感应作为阿尔茨海默病理学的关键介体）并接受了高度 NIA/AFAR（Beeson，Irene Diamond）和VA的竞争职业发展奖。 SA OAIC建立在UTHSCSA杰出且紧密整合的独特基础上 资源：内森冲击中心，干预措施测试计划（ITP）的站点，GRECC，T32培训 Grant on Geroscience和一个强大的酒馆研究所，该研究所在UTHSCSA上衰老。我们是唯一的 OAIC具有所有这些协同组件。此外，SA OAIC接收无与伦比 机构承诺（约60万美元/年），包括新的〜1亿美元109,000平方英尺的建筑物 - 特定于 Barshop Institute - 将在一个位于中央的设施中容纳OAIC，冲击中心和ITP。

项目成果

Binge eating among older women: prevalence rates and health correlates across three independent samples.

• DOI: 10.1186/s40337-021-00484-8
• 发表时间: 2021-10-19
• 期刊: Journal of eating disorders
• 影响因子: 4.1
• 作者: Wilfred SA;Becker CB;Kanzler KE;Musi N;Espinoza SE;Kilpela LS
• 通讯作者: Kilpela LS

Technology-Assisted Self-Monitoring of Lifestyle Behaviors and Health Indicators in Diabetes: Qualitative Study.

• DOI: 10.2196/21183
• 发表时间: 2020-08-28
• 期刊: JMIR diabetes
• 作者: Du, Yan;Dennis, Brittany;Wang, Jing
• 通讯作者: Wang, Jing

The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury.

• DOI: 10.1186/s13195-023-01301-x
• 发表时间: 2023-09-12
• 期刊: Alzheimer's research & therapy

Association of Insurance Type With Colorectal Surgery Outcomes and Costs at a Safety-Net Hospital: A Retrospective Observational Study.

• DOI: 10.1097/as9.0000000000000215
• 发表时间: 2022-12
• 期刊: Annals of surgery open : perspectives of surgical history, education, and clinical approaches

Effect of Dietary Intake Through Whole Foods on Cognitive Function: Review of Randomized Controlled Trials.

通过全食摄入膳食对认知功能的影响：随机对照试验回顾。

• DOI: 10.1007/s13668-022-00412-5
• 发表时间: 2022
• 期刊: Current nutrition reports
• 影响因子: 4.9
• 作者: Jiwani,Rozmin;Robbins,Ronna;Neri,Alfonso;Renero,Jose;Lopez,Emme;Serra,MonicaC
• 通讯作者: Serra,MonicaC