Bioengineering Center for Regeneration and Formation of Tissues (SC BioCRAFT)

组织再生与形成生物工程中心 (SC BioCRAFT)

基本信息

批准号：
10670143
负责人：
Naren R Vyavahare
金额：
$ 114.29万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670143
关键词：
Advisory Committees Affect Allografting Area Autologous Award Basic Science Behavior Biocompatible Materials Biomaterials Research Biomedical Engineering Bone Tissue Capital Cardiovascular Diseases Cardiovascular system Centers of Research Excellence Clinical Collaborations Core Facility Data Development Developmental Biology Diabetes Mellitus Disadvantaged Disease Economics Endowment Engineering Ensure Equipment Evaluation Extramural Activities Faculty Fees Fostering Funding Future Goals Growth and Development function Health Image In Situ Individual Infrastructure Institution Knowledge Lead Leadership Learning Life Medical Medicine Mentors Methods Mission Morbidity - disease rate National Institute of General Medical Sciences Natural regeneration Nature Obesity Organ failure Organism Outcome Peer Review Phase Physiology Pilot Projects Population Positioning Attribute Prosthesis Publications Recovery Regenerative Medicine Research Research Infrastructure Research Personnel Resources Scientist South Carolina Strategic Planning Stroke Structure Technical Expertise Technology Testing Tissue Engineering Tissues Training Translational Research Translations United States National Institutes of Health Universities Xenograft procedure arm biofabrication bioimaging career clinical application clinically relevant cost design disability equipment acquisition faculty research fortification human disease improved innovation inter-institutional interdisciplinary collaboration interest member mortality multidisciplinary neural novel outreach program costs programs recruit stem cells success synergism targeted treatment tissue regeneration tissue repair translational goal voucher

项目摘要

This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center's research: advance biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of normal developmental biology to regenerative medicine or stem cell based tissue engineering. SC BioCRAFT accomplishments towards these three translational goals include the recruitment of 10 new faculty, mentoring and training of 23 COBRE target faculty, and the development of two research core facilities. Programmatic outcomes include 26 independent NIH research awards, 62 research awards from other agencies to target faculty, and >550 peer reviewed publications. South Carolina Centers of Economic Excellence: SmartState awarded three endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication in partnerships with Clemson and the University of South Carolina. SC BioCRAFT participated in the successful renewal of a statewide INBRE award with a focus on bioengineering/regenerative medicine. For this P30 application, the plan transitioning to independence of NIH/NIGMS support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness, to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A seven step, five-year strategic plan including implementing fee structures, pilot projects/voucher program, outreach activities and programmatic development is proposed to sustain the SC BioCRAFT/COBRE center and its scientific cores (Biomaterials Engineering and Testing and Translational Research Imaging). The founding director of Clemson's SC BioCRAFT COBRE will lead the Administrative Core and will be assisted by two outstanding scientists from Medical University of South Carolina who have themselves directed COBREs. Together, these three leaders will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Vice President for Research, ~2 million dollars, will help ensure programmatic growth development and long- term sustainability of the Center.

这项III阶段应用程序旨在维持头十年来建立的研究基础设施 Nigms资金。我们的“南卡罗来纳州南卡罗来纳州生物工程中心的再生和形成中心组织”已成为一个全国认可的协作中心，具有生物工程的独特优势再生医学的方法。三个基本主题定义了该中心的研究：提前生物材料设计和应用；靶向疗法的原位组织修复；并应用原则 SC Biocraft 实现这三个翻译目标的成就包括招募10个新教师以及对23个COBRE目标教师的培训，以及两个研究核心设施的发展。程序化成果包括26个独立NIH研究奖，其他机构的62个研究奖教师和> 550个同行评审出版物。南卡罗来纳州经济卓越中心：SmartState 授予三位赋予再生医学和高级组织生物制造的捐赠椅子与克莱姆森和南卡罗来纳大学一起。 SC Biocraft参加了成功的续约全州近亲奖，重点是生物工程/再生医学。对于此P30申请，计划在未来五年内过渡到NIH/NIGMS支持的独立性是为了增强和升级我们的核心技术，以提高其竞争力，以吸引更大的用法（和成本恢复），并促进与我们的中心的新研究合作，这可能导致提交竞争性的研究应用程序，并扩大了我们全州范围的外展，尤其是对其他思想中心。七步骤，五年的战略计划，包括实施费用结构，试点项目/凭证计划，外展提出了活动和程序性开发，以维持SC Biocraft/Cobre Center及其科学核心（生物材料工程和测试以及翻译研究成像）。开国克莱姆森（Clemson）的SC Biocraft Cobre的主任将领导行政核心，并将在两个南卡罗来纳州医科大学的杰出科学家自己指挥了Cobres。这三个领导人一起将充当该中心的主要运营部门。外部咨询委员会将提供对中心进度的持续评估和评估。机构承诺研究副总裁约200万美元，将有助于确保程序化的增长发展和悠久中心的期限可持续性。