Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10669643
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 38.47万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669643
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Arterioloscleroses; Atherosclerosis; Autopsy; Biological Markers; Blood; Blood Vessels; Brain; Catalogs; Cerebral Amyloid Angiopathy; Cerebrospinal Fluid; Cessation of life; Clinical; Collaborations; Collection; Communication; Communities; Consent; DNA; Data; Data Management Resources; Development; Diagnosis; Diagnostic; Drug or chemical Tissue Distribution; Educational Materials; Faculty; Funding; Goals; Hemorrhage; Home; Image; Image Analysis; Individual; Infarction; Institution; International; Intervention; Laboratories; Latino; Lewy Bodies; Lymphocyte; Mentors; Methods; Microscopic; Modernization; Participant; Pathologic; Pathology; Photography; Play; Prevention; Procedures; Process; Reproducibility; Research; Research Personnel; Resources; Role; Secure; Slide; Specimen; Translational Research; biomarker development; brain tissue; data management; data sharing; digital; education research; flexibility; indexing; innovation; neuroimaging; neuropathology; open data; outreach; preservation; recruit; religious order study; research study; sample collection; tool

ABSTRACT – NEUROPATHOLOGY CORE The Neuropathology Core will play a pivotal role to help achieve the overall Rush ADRC goals by supporting, promoting and facilitating innovative translational research. Specifically, the Neuropathology Core will promote collaborative, transparent, and reproducible research by providing investigators with expertise, mentoring, and a comprehensive and unique resource of biospecimens and data using contemporary laboratory methods, state-of-the-art diagnostics, and sophisticated statistical support and data management. The Neuropathology Core will do this in participation with the Administrative, Data Management and Statistical, Biomarker and Neuroimaging, and Outreach, Recruitment and Engagement Cores, and the Research Education Component working with ADRC core leaders and other colleagues and focusing on our well-characterized subjects in the Clinical Core, Religious Orders Study (ROS) and Latino Cores. Specifically, the Neuropathology Core will (1) Use rapid autopsy and optimal biospecimen collection procedures to obtain antemortem (blood, lymphocytes, DNA) and postmortem (brain, cerebrospinal fluid) biospecimens (2) Preserve, process and store antemortem (blood, lymphocytes, DNA) and postmortem (brain and CSF) biospecimens for clinical-pathologic and innovative translational research by using uniform best practice procedures for research studies while maintaining flexibility to accommodate special needs of specific researchers, studies, and collaborations. (3) Perform state-of-the-art assessments on brain tissue using contemporary macroscopic and microscopic procedures and collect state-of-the-art neuropathologic data and diagnoses, including data on AD, Lewy body, TDP, and HS, and vascular (gross and microinfarcts, hemorrhages, atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy) pathologies to support a wide range of studies. (4) Distribute antemortem and postmortem specimens and data, share expertise, and mentor junior researchers and faculty in neuropathology by making biospecimens, data, and expertise assessable to junior and established investigators within and across the ADRC community, and outside of the centers; also partaking in collaborative studies with other centers and projects funded by the National Institution Aging (e.g., NACC, ADGC) and other organizations seeking to advance research in AD/ADRD. (5) Catalogue all biospecimens, photography, neuropathologic data and diagnoses, digital slide images and tissue distribution, using modern and secure data management systems. These activities will support, promote and facilitate innovative translational research that will lead to effective prevention, diagnosis, and interventions for Alzheimer’s disease and Alzheimer’s Disease Related Disorders.

摘要 - 神经病理学核心 神经病理学核心将发挥关键作用，以通过支持， 促进和支持创新的转化研究。具体而言，神经病理学核心将促进 通过为研究人员提供专业知识，心理和可再现的研究 使用当代实验室方法的生物测量和数据的全面而独特的资源， 最先进的诊断以及复杂的统计支持和数据管理。神经病理学 核心将在参与行政，数据管理和统计，生物标志物以及 神经影像，外展，招聘和参与核心以及研究教育部分 与ADRC核心领导人和其他同事一起工作，并专注于我们在 临床核心，宗教秩序研究（ROS）和拉丁裔核心。具体而言，神经病理学核心将（1） 使用快速的尸检和最佳的生物循环收集程序来获得触角（血液，淋巴细胞， DNA）和验尸（大脑，脑脊液）生物测量（2）保存，过程和存储Anthertem （血液，淋巴细胞，DNA）和验证后（脑和CSF）生物症状，用于临床病理学和 创新的翻译研究通过使用统一的最佳实践程序进行研究 保持灵活性以满足特定研究人员，研究和合作的特殊需求。 （3） 使用现代宏观和微观对脑组织进行最新评估 程序并收集最新的神经病理学数据和诊断，包括有关AD的数据，Lewy身体， TDP和HS，以及血管（毛和微作用，出血，动脉粥样硬化，小动脉粥样硬化和 脑淀粉样蛋白血管病）病理学以支持广泛的研究。 （4）分发国歌和 验尸标本和数据，分享专业知识以及心理初级研究人员和教师 神经病理学通过制作可评估的生物测量，数据和专业知识，并建立 ADRC社区内外的调查人员以及中心以外；也参与其中 与国家机构老化资助的其他中心和项目的合作研究（例如NACC， ADGC）和其他寻求在AD/ADRD进行研究的组织。 （5）所有生物测量的分类， 摄影，神经病理学数据和诊断，数字幻灯片图像和组织分布，使用现代 并确保数据管理系统。这些活动将支持，促进和促进创新 转化研究将导致阿尔茨海默氏病有效预防，诊断和干预措施 和阿尔茨海默氏病有关的疾病。